Detection of Human Herpesviruses in Sera and Saliva of Asymptomatic HIV-Infected Individuals Using Multiplex RT-PCR DNA Microarray

Sufiawati, Irna; Harmiyati, Rahmi; Nur’aeny, Nanan; Indrati, Agnes Rengga; Lesmana, Ronny; Wisaksana, Rudi; Amalia, Riezki

doi:10.3390/pathogens12080993

Cited by 4 publications

(1 citation statement)

References 63 publications

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“… 11 However, a study has reported that men are more frequently affected than women. 17 Intrinsic biological differences between men and women can have a significant impact on the progression of HIV infection. These sex-related factors influence HIV acquisition, viral replication, pathogenesis, and the type of ART used for pre-exposure prophylaxis or treatment.…”

Section: Discussionmentioning

confidence: 99%

Case Series of HIV-Associated Oral Lesions Across Different Clinical Stages in People Living with HIV

Permatasanti,

Sufiawati

2024

HIV

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Introduction Human immunodeficiency virus (HIV) impairs immune function leading to oral mucosal lesions. While highly active antiretroviral therapy (HAART) has reduced the incidence of HIV-associated oral lesions (HIV-OLs), these lesions can still manifest across all HIV stages due to various patient-related factors. Purpose To evaluate the occurrence of HIV-OLs and clinical characteristics across all HIV stages in people living with HIV (PLWH). Patients and Methods Five patients aged 7 to 60 with canker sores visited the Oral Medicine Clinic. One newly diagnosed patient with stage II HIV had not yet started ART, while others in stages I, III, and IV were already receiving ART. Diagnosed oral lesions included recurrent intraoral herpes (RIH) in patients with stages I, II, and III; linear gingival erythema (LGE) in stages I; acute pseudomembranous candidiasis (APC) and oral hairy leukoplakia (OHL) in stages II; traumatic ulcers in stages III; erythema multiforme (EM) and angular cheilitis (AC) in stages IV. Potential risk factors for these oral lesions included poor oral hygiene, low CD4+ T-cell counts, detectable viral load, non-adherence to ART, smoking, medication use for systemic diseases, nutritional deficiency, and comorbidities. Results Treatment included antiviral for RIH; antifungal for APC and AC; topical corticosteroid and antiseptic mouthwash for oral ulcers and improving oral hygiene; application of normal saline-soaked gauze dressing followed by topical steroid for EM; petroleum jelly for dry lips; and multivitamins. Lesions improved over 5–15 days. Addressing risk factors involved improving oral hygiene, treating comorbidities, promoting weight gain, smoking cessation, and starting ART for those untreated. Conclusion Oral lesions are prevalent throughout the stages of HIV and are influenced by immune status, medication adherence, and overall health, underscoring the need for holistic care to enhance the quality of life, potentially alter HIV progression, and reduce morbidity through integrated oral health assessments in routine care.

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Section: Discussionmentioning

confidence: 99%