Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran

Falaki, Farnaz; Chaghmaghi, M. Amir; Pakfetrat, Atessa; Delavarian, Zahra; Mozaffari, Pegah Mosannen; Pazooki, Nazanin

doi:10.1111/j.1600-0714.2009.00784.x

Cited by 22 publications

(28 citation statements)

References 15 publications

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“…In addition, lower lip and lateral tongue were affected more frequently than upper lip and other tongue portions respectively, suggesting trauma as a contributing factor. Viral etiology was established in 7:12 of patients and HPV13 has been the most associated subtype (5 cases), that was similar to other studies (1,3,7,8,11). HPV32 was also positive in one patient.…”

Section: Discussionsupporting

confidence: 69%

“…Although poverty has been suggested as a relative factor in many studies (1)(2)(3)8), but all of our patients were from a middle socio economic group. Affirming to most studies, the majority of patients were female (7:12) (1,2,7,8), although some studies have reported a male predilection (2,11,12). Familial involvement has been reported in most previous studies, but our patients didn't report such finding.…”

Section: Discussioncontrasting

confidence: 54%

“…Molecular techniques such as polymerase chain reaction (PCR) or in-situ hybridization can be used to examine the presence of human papilloma virus (HPV) in many instances. The most common associated subtypes are 13, 32, although Cross reaction with other subtypes (6,11,16,8,55) has also been reported (1,3,7). Certain HLA subtypes have been related to this disease (9).…”

Section: Introductionmentioning

confidence: 99%

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Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

Mosannen-Mozaffari¹,

Falaki²,

Amirchaghmaghi³

et al. 2010

Med Oral

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Objectives: Multifocal epithelial hyperplasia (MEH) is benign, asymptomatic oral disease with viral etiology. The frequency of this disease varies widely from one geographic region to another, and can vary, from 0.002 to 35% depending on the population studied. Study design: Here we report the clinicopathological features of twelve cases of MEH referred to Oral Medicine Department of Mashhad Dental School for the first time in Iran. Records of patients with the diagnosis of MEH in our department during 7 years were analyzed and data were extracted. Results: Most of the patients were younger than 20-year-old (66%), and females were predominantly affected (7:12). The mean age of onset was 12.72±10.14 years and the mean duration was 52.54 ± 78.51 months. Patients had multiple, well circumscribed, soft, non tender, flattened papules, with a color similar to the adjacent mucosa, in different areas of the oral cavity but the most affected site was buccal mucosa. Familial history of such lesions was negative in all patients. Only three cases showed spontaneous regression. Conclusion: In spite of rare nature of this disease in Asia, it seems that it is not the case in Khorasan Province, southeast Iran.

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Section: Discussionsupporting

confidence: 69%

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

Mosannen-Mozaffari¹,

Falaki²,

Amirchaghmaghi³

et al. 2010

Med Oral

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“…FEH is relatively rare in Asian populations 2,5 . There has been no exact and complete report of FEH in an ethnic Chinese population.…”

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confidence: 99%

Focal epithelial hyperplasia (Heck's disease) in two Chinese females

Liu

Zhou

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…It has mainly been observed among isolated groups of native Indians in North, Central and South America and in other very small population groups in Europe and Africa (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Multifocal epithelial hyperplasia: A potentially precancerous disease? (Review)

Bascones-Martínez¹,

Cok²,

Bascones-Ilundáin³

et al. 2011

Oncology Letters

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Abstract. Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, manifests as a papulonodular lesion in the oral mucosa and has been associated with the human papillomavirus, a virus related to various precancerous diseases in the oral cavity. It has a predisposition for the female gender and for children. Although the majority of reported cases have been among American Indians and Eskimos, it has been described in multiple ethnic groups in various geographical locations. The objective of this review was to report on the clinical characteristics and epidemiology of MEH and its possible correlation with oral cancer. It is based on a search of articles in international journals published prior to April 2011, using the PubMed database and selecting articles related to the epidemiology and clinical characteristics of MEH. The review revealed a higher number of cases in individuals of American Indian origin and a predilection of the disease for the female gender and for patients between the 1st and 2nd decades of life. The most frequent lesion site was the lower lip. The disease has been associated with socio-economic and genetic factors, among others. No cases of malignant transformation have been reported.

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Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran

Abstract: Similar with other studies about FEH, most of our cases were associated with HPV 13 but other subtypes may also be implicated.

Cited by 22 publications

References 15 publications

Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

Focal epithelial hyperplasia (Heck's disease) in two Chinese females

Multifocal epithelial hyperplasia: A potentially precancerous disease? (Review)

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