Detection of human papillomavirus-6 in primary carcinoma of the urethra in men

Grussendorf-Conen, Elke-Ingrid; Deutz, F.-J.; Villiers, Ethel‐Michele de

doi:10.1002/1097-0142(19871015)60:8<1832::aid-cncr2820600826>3.0.co;2-2

Cited by 36 publications

(11 citation statements)

References 21 publications

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“…4 However, the majority of primary tumors arising in the anterior urethra are of squamous type, and many are HPVrelated, whereas those of the posterior urethra are transitional, non-HPV-related and similar to homologous lesions in the urinary tract. 5,6 These observations are consistent with the different anatomic features found at both sites. The posterior urethra is lined by a transitional epithelium, and the anterior urethra by a distinct and not-well-studied epithelium composed of a single layer of columnar cells at the surface, and a stratified or pseudostratified epithelium of small cells with round nuclei at the base.…”

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confidence: 77%

Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases

et al. 2005

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Urethral and penile tissues and their neoplasms are considered anatomically and pathogenetically different. Since we observed urethral dysplastic lesions and some similarities between noninvasive and invasive lesions of the anterior urethra and glans, we designed this study to document epithelial urethral abnormalities in patients with penile squamous cell carcinoma. We examined urethral epithelia from 170 penectomies with invasive squamous cell carcinoma finding a variety of primary epithelial abnormalities in 89 cases (52%) and secondary invasion of penile carcinoma to urethra in 42 cases (25%). Patients' average age was 68 years. Primary tumors measured 4 cm in average diameter and the majority were squamous cell carcinoma of the usual (67%) or verrucous type (15%). Primary epithelial abnormalities found were squamous intraepithelial lesions, metaplasias and microglandular hyperplasias. Urethral squamous intraepithelial lesions of high grade was found in six patients and of low grade in eight cases. Squamous metaplasia, seen in 69 cases, was the most frequent finding. Metaplasias were classified as nonkeratinizing and keratinizing. Nonkeratinizing metaplasias (57 cases) were variegated in morphology: simplex (26 cases), hyperplastic (12 cases), clear cell (11 cases) and spindle (8 cases). Keratinizing metaplasias (12 cases) showed hyperkeratosis and were more frequently associated with verrucous than nonverrucous penile squamous cell carcinoma. Microglandular hyperplasia was present in eight cases. Lichen sclerosus was associated with simplex squamous metaplasia in four cases. Despite the large size of the primary tumors, direct urethral invasion by penile carcinoma was present in only 25% of the cases. The presence of precancerous lesions in urethra of patients with penile carcinoma indicates urethral participation in the pathogenesis of penile cancer. Simplex squamous metaplasia is a common finding probably related to chronic inflammation. Keratinizing and hyperplastic squamous metaplasias may be important in the pathogenesis of special types of penile carcinomas such as verrucous carcinoma. Modern Pathology (2005) 18, 917-923.

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confidence: 77%

Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases

et al. 2005

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“…HPV 6 DNA has been found in carcinomas [51,52] and giant condylomas (Buschke–Löwenstein tumours) [53,54]. The molecular mechanism by which these low-risk HPV types induce or participate in the transformation of cells has not been resolved.…”

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confidence: 99%

Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast

et al. 2004

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Background Viruses including Epstein-Barr virus (EBV), a human equivalent of murine mammary tumour virus (MMTV) and human papillomavirus (HPV) have been implicated in the aetiology of human breast cancer. We report the presence of HPV DNA sequences in areolar tissue and tumour tissue samples from female patients with breast carcinoma. The presence of virus in the areolar-nipple complex suggests to us a potential pathogenic mechanism.

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“…Clinically they are regarded as malignant tumours. Other tumours in which HPV-6 DNA has been detected include verrucous carcinoma of the vagina (Okagaki et al, 1984) and of the vulva (Rando et al, 1986 a;Kasher & Roman, 1988), cervical carcinoma and one case of bladder carcinoma (Oft et al, 1993), a primary carcinoma of the urethra (Grussendorf-Conen et al, 1987), a condyloma of the mamilla (Kulke et al, 1989), a case of lung carcinoma (DiLorenzo et al, 1992), as well as a tonsillar carcinoma (Bercovich et al, 1991). In all these cases, analyses of the HPV-6 DNA genomes revealed insertions and/or duplications in the upstream regulatory region (URR).…”

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confidence: 99%

Sequence Rearrangements in the Upstream Regulatory Region of Human Papillomavirus Type 6: are these Involved in Malignant Transition?

Kitasato

Delius

Hausen

et al. 1994

Journal of General Virology

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Detection of human papillomavirus-6 in primary carcinoma of the urethra in men

Cited by 36 publications

References 21 publications

Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases

Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases

Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast

Sequence Rearrangements in the Upstream Regulatory Region of Human Papillomavirus Type 6: are these Involved in Malignant Transition?

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