Detection of Human PapillomaVirus and its Association with Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Rathore, Anushree; Tiwari, Anushree; Nazim, Maira; Gupta, Anup Kumar; Gande, Mounica; Krishnakumar, Jyothi

doi:10.4103/jpbs.jpbs_9_22

Cited by 11 publications

(2 citation statements)

References 10 publications

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“…Previous research has demonstrated the efficacy of corticosteroid treatments, whether applied topically or via injection, in reducing the size of OLP lesions [29][30][31][32][33]. The assessments provide a quantitative measure of lesion size in terms of standardized qualitative measures [34][35][36]. Several studies have specifically investigated and compared the effects of PRP and TA applications on OLP lesions, focusing on changes in lesion sizes [28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Injectable Platelet-Rich Fibrin in the Treatment of Oral Lichen Planus: A Systematic Review and Meta-Analysis

Gupta,

Bhargava,

Saigal

et al. 2024

Cureus

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Oral lichen planus (OLP) is a chronic inflammatory condition affecting the oral mucosa. The current review investigated the potential effectiveness of injectable platelet-rich fibrin (i-PRF) as a treatment for OLP when compared to other interventions. The current review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search strategy was implemented across databases such as PubMed, Embase, Scopus, Web of Science, CINAHL, and Google Scholar. The search utilized a combination of Boolean operators (AND, OR) and Medical Subject Headings (MeSH) terms to capture relevant studies. Comparative clinical studies focusing on i-PRF as a treatment for OLP and other interventions were included. Outcomes assessed were pain, surface area of lesions, and patient satisfaction. Review Manager 5.4 was used for statistical analysis. The Risk of Bias 2.0 (RoB 2.0) tool was used to assess the methodological quality of the studies. Three studies were included for the final analysis. The findings indicated that both the i-PRF and comparison treatment groups demonstrated reductions in pain and lesion size. The post-treatment Visual Analogue Scale (VAS) scores showed a decrease in pain intensity, and there was an improvement in lesion extension in the i-PRF-treated sites. The results also revealed increased patient satisfaction with i-PRF treatment. Adverse effects were not reported or specified in the included studies. Quantitative analysis for pain (VAS) showed a mean difference of 0.38 (95% CI: 0.63-1.40), but there was no significant difference between the i-PRF and control groups at p=0.46. Though intragroup differences showed statistically significant differences between pre and post intervention, intergroup differences were not significant for any of the assessed outcomes. The findings from this study suggest that i-PRF holds promise as a potential treatment for OLP. The use of i-PRF resulted in pain reduction, lesion size improvement, and increased patient satisfaction. However, it is important to consider the limitations of the included studies, such as variability in study designs, small sample sizes, and the limited number of studies.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Injectable Platelet-Rich Fibrin in the Treatment of Oral Lichen Planus: A Systematic Review and Meta-Analysis

Gupta,

Bhargava,

Saigal

et al. 2024

Cureus

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“…[ 7 ] Saliva offers several advantages, including easy and non-invasive sample collection, making it an attractive medium for biomarker analysis. [ 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Salivary Interleukin-1 Levels in Oral Squamous Cell Carcinoma: A Case-Control Study

Vala,

Shah,

Purba

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Objective: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with a significant impact on global health. The identification of non-invasive biomarkers for early detection and monitoring of OSCC remains crucial. Methods: A total of 100 subjects, comprising 50 patients with histopathologically confirmed OSCC and 50 age- and sex-matched healthy controls, were enrolled in the study. Salivary samples were collected from all participants and analyzed using enzyme-linked immunosorbent assays (ELISA) to measure IL-1 levels. Clinical data, including demographic information, smoking habits, and alcohol consumption, were obtained from patient records. Results: The mean salivary IL-1 level was significantly higher in OSCC patients compared to healthy controls (P < 0.001). Furthermore, subgroup analysis demonstrated that advanced stages of OSCC correlated with significantly elevated IL-1 levels when compared to early-stage OSCC (P < 0.05). Additionally, high salivary IL-1 levels were associated with a more aggressive tumor phenotype and poorer prognosis, as reflected by tumor size, lymph node metastasis, and overall survival (P < 0.01). Conclusion: This case-control study provides compelling evidence that salivary Interleukin-1 (IL-1) levels are significantly elevated in patients with OSCC.

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Prevalence of Oral Lichen Planus in Patients with Hypothyroidism Versus Nonhypothyroidism

Bansal,

Raj,

Gupta

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Background: A chronic inflammatory illness known as oral lichen planus (OLP) affects approximately 1–2% of adults, with middle-aged women having a higher prevalence than men. One clinical endocrine condition that primary care doctors frequently see is hypothyroidism. Aim: To compare the prevalence of OLP among individuals with a previous diagnosis of hypothyroidism against those without hypothyroidism. Methods and Materials: A total of 1200 patients were included in this study. As per their medical reports, 600 patients included were found to have hypothyroidism. The rest 600 patients did not have hypothyroidism. All the patients underwent clinical examination and cases of OLP were identified according to the criteria of diagnosis of OLP. Results: Twenty (3.45%) study participants with hypothyroidism were found to have OLP. Eight (1.34%) study participants without hypothyroidism were found to have OLP of 2.37 (confidence interval: 0.91–6.23) and showed that the frequency of lichen planus in study participants with hypothyroidism was 2.37 times greater than that without hypothyroidism. Conclusion: Prevalence of lichen planus in persons with hypothyroidism was greater than that without hypothyroidism.

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Detection of Human PapillomaVirus and its Association with Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Cited by 11 publications

References 10 publications

Effectiveness of Injectable Platelet-Rich Fibrin in the Treatment of Oral Lichen Planus: A Systematic Review and Meta-Analysis

Effectiveness of Injectable Platelet-Rich Fibrin in the Treatment of Oral Lichen Planus: A Systematic Review and Meta-Analysis

Salivary Interleukin-1 Levels in Oral Squamous Cell Carcinoma: A Case-Control Study

Prevalence of Oral Lichen Planus in Patients with Hypothyroidism Versus Nonhypothyroidism

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