Detection of human papillomavirus DNA in tumors from Rwandese breast cancer patients

Habyarimana, Thierry; Attaleb, Mohammed; Mazarati, Jean Baptiste; Bakri, Youssef; Mzibri, Mohammed El

doi:10.1007/s12282-018-0831-2

Cited by 28 publications

(25 citation statements)

References 35 publications

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“…In our study, the overall prevalence of high-risk HPV infection was 15%. Our results corroborate the majority of studies that investigate the presence of viral HPV-DNA in cases of breast cancer worldwide [12, 22, 23]. However the prevalence observed in our study was low compared to other studies conducted worldwide [22, 24, 25].…”

Section: Discussionsupporting

confidence: 91%

“…Our results corroborate the majority of studies that investigate the presence of viral HPV-DNA in cases of breast cancer worldwide [ 12, 22, 23 ]. However the prevalence observed in our study was low compared to other studies conducted worldwide [ 22, 24, 25 ]. However, the relative size of our sample could not allow us a good comparison of prevalence with the other studies and the descriptive character of our study rightly limits its scope.…”

Section: Discussioncontrasting

confidence: 85%

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Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients

Boumba

Moudiongui

Ngatali

et al. 2021

Access Microbiology

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Background. Since the work of Band et al. in 1990 (Proc. Natl. Acad. Sci. USA 87:463–467), several studies have suggested a possible link between the pathogenesis of breast cancer and viral infection. Infection with oncogenic HPV has been one of the viruses implicated in breast cancer cases worldwide. Objective. To investigate the presence of HPV DNA in archived paraffin-embedded breast cancer cases at the University Hospital of Brazzaville and to assess the association between viral HPV infections and clinicopathological features. Methods. A total of 40 formalin-fixed paraffin-embedded (FFPE) biopsies were retrospectively collected and available information was recorded. HPV detection and genotyping were performed by real-time PCR by GeneXpert technology (Cepheid, Sunnyvale, USA). Results. The mean age was 51.1±11.4 years (range 22–75 years; median was 47). Overall, HPV DNA was detected in six (15%) breast carcinoma samples. HPV-16, the most common genotype was identified in 83.7 % of all samples. HPV porting with clinicopathological features showed no significant difference (P>0.05). However, a statistically significant difference was observed between HPV infection and SBR grade (P=0.05). Conclusion. Our study described a high prevalence of HPV-HR in breast cancer cases in the Congolese woman. Future type case-control studies are necessary to better describe the potential role of HPV in the occurrence of breast cancer in Congo.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 85%

Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients

Boumba

Moudiongui

Ngatali

et al. 2021

Access Microbiology

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“…These were the only two studies that reported this virus in Africa. Studies have also shown an association of the hepatitis C virus in Egypt ( 100 ) and Human papillomavirus (HPV) in Rwanda ( 101 ) to breast cancer progression. However, the most reported virus linked to breast cancer in Africa is the Epstein-Barr virus (EBV), with studies published in Algeria ( 102 ), Eritrea ( 103 ), Egypt ( 104 ), and Sudan ( 105 ).…”

Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

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Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause of mortality in Africa within the next two decades. Cancer is a group of genomic diseases that presents with intra- and inter-population unique phenotypes, with Black populations having the burden of morbidity and mortality for most types. At large, the prevention and treatment of cancers have been propelled by the understanding of the genetic make-up of the disease of mostly non-African populations. By the same token, there is a wide knowledge gap in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans. Accordingly, we performed a review of the literature to survey existing studies on cancer genetics/genomics and curated findings pertaining to publications across multiple cancer types conducted on African populations. We used PubMed MeSH terms to retrieve the relevant publications from 1990 to December 2019. The metadata of these publications were extracted using R text mining packages: RISmed and Pubmed.mineR. The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our review. The most frequently reported cancer genes were BRCA1, BRCA2, and TP53. Next, the genes reported in the reviewed publications’ abstracts were extracted and annotated into three gene ontology classes. Genes in the cellular component class were mostly associated with cell part and organelle part, while those in biological process and molecular function classes were mainly associated with cell process, biological regulation, and binding, and catalytic activity, respectively. Overall, this review highlights the paucity of research on cancer genomics on African populations, identified gaps, and discussed the need for concerted efforts to encourage more research on cancer genomics in Africa.

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“…The proposal of alternative strategies for support technologies involving the reduction in the number of steps for DNA extraction and amplification are very useful in rapid and low cost diseases diagnosis approach . These approaches can be explored in the miniaturization of diagnostic sets to permit the development of assays in the absence of laboratory conditions .…”

Section: Resultsmentioning

confidence: 99%

Eudragit E100/poly(ethylene oxide) electrospun fibers for DNA removal from aqueous solution

Barbosa

França

Gouveia

et al. 2019

J of Applied Polymer Sci

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The development of new strategies for production of low‐cost deoxyribonucleic acid (DNA) adsorbents based on electrospun fibers of block copolymers [Eudragit E‐100/poly(ethylene oxide) (PEO)] is a promising way for fast retrieval of free of degradation double‐stranded DNA chains from aqueous solution. The adsorption takes place through electrostatic interaction between DNA and oppositely charged electrospun fibers that provide high surface area for DNA adsorption. The adsorption capacity observed for electrospun fibers of Eudragit E100/PEO (considering as target molecules the salmon sperm DNA) was in order of 44.31 mg g−1, following the Langmuir model in a typical adsorption at solid/liquid interface (pseudo‐second‐order model), that characterizes the electrospun fibers as promising templates for removal of biologic components and further use in molecular biology techniques, as DNA amplification by polymerase chain reaction. The reuse and integrity of membranes after long period of adsorption were tested, confirming the potential of material as adsorbent. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47479.

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Detection of human papillomavirus DNA in tumors from Rwandese breast cancer patients

Abstract: These findings provide evidence of high prevalence of high-risk HPV in Rwandese patients with breast cancer and suggest that high-risk HPV infections could be a risk factor associated with human breast cancer development.

Cited by 28 publications

References 35 publications

Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients

Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients

A Review of Cancer Genetics and Genomics Studies in Africa

Eudragit E100/poly(ethylene oxide) electrospun fibers for DNA removal from aqueous solution

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