Detection of Human Papillomavirus in Nonmelanoma Skin Cancer Lesions and Healthy Perilesional Skin in Kidney Transplant Recipients and Immunocompetent Patients

Bernat-García, Josefa; Suárez-Varela, M. Morales; Vilata-Corell, J.J.; Marquina-Vila, A.

doi:10.1016/j.adengl.2013.10.008

Cited by 12 publications

(16 citation statements)

References 30 publications

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“…Test for overall effect Z = 5.12 (p < 0.00001) Three [21,23,45], four [21,23,45,49], three [21,23,45], two [21,23], and six studies [8,9,13,29,42,46] reported the prevalence of HPV 49 (β3), HPV 76 (β3), HPV 92 (β4), HPV 96 (β5), and HPV (unlisted type) in the BCC patients. Four [5,21,22,48], five [23,28,45,49,50], seven [2,21,23,28,45,47,50], two [2,21], six [2,21,23,28,45,50], five [21,23,28,45,50], four [21,23,45,…”

Section: Epidermodysplasia Verruciformis-hpv (Ev-hpv)mentioning

confidence: 99%

“…Out of 45 studies reported during 1991 to 2017; two studies were reported in Australia [12,13], one Romania [14], ten USA [15,16,17,18,19,20,21,22,23,24], one Argentina [1], four Netherlands [25,26,27,28], two Spain [8,11], one Brazil [29], one China [30], one UK [31], one Croatia [2], four Iran [9,32,33,34], one North Africa/France [35], one Germany/USA [36], two Greece [37,38], one Sweden/Austria [39], two Germany [40,41], five Italy [5,42,43,44,45], one Russia [46], one Germany/Poland [47], one Norway/Sweden [48] and two Sweden [49,50] (Table I). Fifteen studies were case-control and 30 studies were cross-sectional studies.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Fifteen studies were case-control and 30 studies were cross-sectional studies. Twenty-four studies did polymerase chain reaction (PCR) [1,2,12,14,19,20,21,25,28,29,31,32,35,36,37,39,40,41,42,43,44,46,47,49,50], 2 in situ hybridization (ISH) [15,18], 3 serology [16,48,24], 7 nested PCR [5,8,11,26,27,34,43], one loop-mediated isothermal amplification assay (LAMP)/PCR [30], 4 multiplex serology [17,22,38,45], 2 immunohistochemistry (IHC) [9,33] Meta-analysis Figure 2 shows the incidence of number of HPVs in the BCC patients and controls. Some studies reported this incidence in the BCC patients and controls (case-control studies) and other studies only reported in BCC patients (cross-sectional and cohort studies).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…EV is a rare genodermatosis associated with infections with specific HPVs belonging to the β genus of HPV [7]. Some of the cutaneous HPVs of the genus β have been suggested as a co-factor in the development of non-melanoma skin cancer (NMSC) [1,8]. NMSCs are squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) that BCC is the most common skin malignancy and represents approximately 75% of all skin cancers, mostly in the sun-exposed areas [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Ramezani¹,

Sadeghi²

2017

pjp

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Human papillomaviruses (HPVs) are a large and ubiquitous group of viruses that some of them have been suggested as a co-factor in the development of non-melanoma skin cancers. The aim of this meta-analysis study was to evaluate HPVs' prevalence in basal cell carcinoma (BCC) of the skin and the risk of them in the BCC patients compared with the healthy controls. Five databases were searched from January 1980 to February 2017. A random-effects meta-analysis was done with the event rate (ER) for the prevalence of HPVs and odds ratio (OR) for estimation of the incidence of HPVs. Out of 1087 studies, 45 studies were included in the review. The pooled analysis demonstrated that the incidence of γ-HPV was effective in the BCC patients compared with the healthy controls [OR = 1.97; 95% CI: 1.52-2.55; p < 0.00001], but not for α-HPV, β-HPV and epidermodysplasia verruciformis (EV)-HPV (p > 0.05). The pooled ER of incidence of β1-HPV in the BCC patients was 33.3% and for β2-HPV in BCC patients was 44.2%. In conclusion, this meta-analysis showed that probably the risk of γ-HPV was more on BCC patients and also the rate of γ-HPV was higher than α-, β-and EV-HPVs in the BCC patients.

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Section: Epidermodysplasia Verruciformis-hpv (Ev-hpv)mentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Ramezani¹,

Sadeghi²

2017

pjp

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“…The most common malignancy observed in solid organ transplant recipients is non-melanoma skin cancer (NMSC) [10][11][12] and particularly in squamous cell carcinoma (relative risk 14-82) [13,14]. Many etiologic factors such as ultraviolet radiation, human papillomavirus infection, genetics and immunosuppressive therapy play an important role in the occurrence of post-transplant NMSC [15,16]. The International Society of Heart and Lung Transplantation (ISHLT) recently reported that among solid tumours, lung carcinoma is the second most common malignancy after skin carcinoma [17].…”

Section: Introductionmentioning

confidence: 99%

Are We Late in the Diagnosis of Malignities Occurring in Solid Organ Transplant Patients? 11 Years’ Experience

et al. 2016

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Objective: Our aim is to evaluate the frequency and characteristics of cancer in the population of patients with solid organ transplant who are under immunosuppressive medication. In this study we aimed to emphasize the importance of early diagnosis of cancer in solid organ transplant recipients. An aging population began to receive solid organ transplantation and survival times prolonged. But this had a cost and new problems came forward. Especially de novo cancers because of immunosuppressive therapy took notice. Risk of malignancy increases after organ transplantation and cancer incidence was about 2.3-3.1% in these patients including skin cancer, lung cancer, malign lymphoma, cervix cancer, kaposi sarcoma, and hepatobiliary cancer. Materials and Methods:The files of 328 organ transplant recipients followed from January 2004 to April 2015 at Atatürk University Medical Faculty were retrospectively reviewed.Results: Eight patients developed cancer (2.4%). There were six males and two females. Age at cancer diagnosis ranged from 42 to 79 years old with average of 55 years. The interval from solid organ transplantation to cancer diagnosis ranged from 6 months to 30 years. Among the patients, five were renal transplant recipients and two were liver transplant recipients. Four patients had stage IV disease, one patient stage IIIB, and three patients had stage I disease. For none of the patients a diagnosis with screening methods was used for cancer before any complaints of tumor emerged. Conclusion:To diagnose cancer at early stages in solid organ transplant recipients, earlier and detailed cancer screening is very important. The association between diagnosis of cancer at early stages and prolonged overall survival time is well known. Detailed and careful evaluation for occult malignancies in pre-transplantation period is also important. Keywords: Cancer, immunosuppression, screening, transplantation ÖzAmaç: Amacımız solid organ transplantı olan, immunsupresif tedavi altındaki hastalarda gelişen kanser sıklığını ve özelliklerini değerlendirmektir. Bu çalışmada, solid organ transplant alıcıla-rında gelişen kanserlerin erken tanısının önemini vurgulamayı amaçladık. Yaşlanan nüfusla birlikte artan solid organ transplantı ile hayatta kalma süreleri uzamıştır. Fakat bu durum yeni maliyetler getirmiş ve yeni sorunlara neden olmuştur. Özellikle immunsupresif tedavilerin sonucunda de novo kanserler görülme-ye başlamıştır. Organ nakli sonrası kanser riski artar ve en sık cilt kanseri, akciğer kanseri, malign lenfoma, serviks kanseri, kaposi sarkomu ve hepatobilier kanseri içeren bu grupta insidans %2,3-3,1'dir. Sonuç: Solid organ transplant alıcılarında erken evrede kanser tanısı için ayrıntılı ve erken kanser taraması çok önemlidir. Erken tanı ve tedavi ile uzun süreli genel sağkalım arasındaki ilişki iyi bilinmektedir. Nakil öncesi dönemde okült maligniteler için detaylı ve dikkatli bir değerlendirme de önemlidir. Gereç ve

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Investigation of three oncogenic epitheliotropic viruses shows human papillomavirus in association with non-melanoma skin cancer

Baez

Venceslau

Rocha

et al. 2019

Eur J Clin Microbiol Infect Dis

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Detection of Human Papillomavirus in Nonmelanoma Skin Cancer Lesions and Healthy Perilesional Skin in Kidney Transplant Recipients and Immunocompetent Patients

Abstract: We found a wide range of HPV types (mostly HPV-β) in the skin of kidney transplant recipients and immunocompetent patients with skin cancer.

Cited by 12 publications

References 30 publications

Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Are We Late in the Diagnosis of Malignities Occurring in Solid Organ Transplant Patients? 11 Years’ Experience

Investigation of three oncogenic epitheliotropic viruses shows human papillomavirus in association with non-melanoma skin cancer

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