Detection of human papillomavirus type 34 in Bowen's disease on the pubic area

Abstract

We describe an 86-year-old man with Bowen's disease on the pubic area. The lesion was clinically a black-brownish keratotic nodule resembling seborrheic keratosis. Histopathological findings showed those of Bowen's disease and harboured human papillomavirus type 34 DNA. Genital, but not skin, human papillomaviruses are responsible for Bowen's disease on the skin.

Squamous cell carcinoma in situ in skin: what does it mean?

“…Bowen’s disease was in the past largely reported to be associated with arsenic ingestion, which would explain the higher incidence of visceral malignancy. Presently, Bowen’s disease may arise de novo or may be associated with human papillomavirus (HPV) 17,18 . It is therefore important to differentiate actinic keratosis and Bowen’s disease on a clinical basis, as they may have different prognoses.…”

“…Presently, Bowen's disease may arise de novo or may be associated with human papillomavirus (HPV). 17,18 It is therefore important to differentiate actinic keratosis and Bowen's disease on a clinical basis, as they may have different prognoses.…”