Detection of human parvovirus B19 infection in the thymus of patients with thymic hyperplasia-associated myasthenia gravis

Gong, Li; Li, Y.; Li, X.; Tao, Qian; Mou, Xianbo; Wang, S.; Wan, Yi; Lü, Qiang; Wang, J.; Zhang, W.; Zhu, Shaojun; Han, Xinpeng; Li, Yao; Zhang, J.; Huang, Gaosheng

doi:10.1016/j.cmi.2018.03.036

Cited by 14 publications

(19 citation statements)

References 26 publications

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“…The most common viruses implicated are varicella, parvovirus B19 and West Nile virus. 10 MIS-C is now a recognised disease associated with SARS-CoV-2 occurring a few weeks after the peak of COVID-19, with the majority of cases having a negative antigen test but a positive antibody test, which was the case in this patient. The precise reason of how SARS-CoV-2 causes MIS-C is still unknown.…”

Section: Outcome and Follow-upmentioning

confidence: 56%

Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection

et al. 2021

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We report on a unique case of a 7-year-old girl with new onset ocular myasthenia gravis shortly after recovery from multisystem inflammatory syndrome in children (MIS-C) temporally associated with SARS-CoV-2 infection. The diagnosis of myasthenia gravis was based on suggestive symptoms of fatigable bilateral orbital ptosis, diplopia, positive ocular cold compression test and serum acetylcholine receptor antibody positivity, as well as a favourable treatment response to pyridostigmine. The addition of corticosteroids and methotrexate resulted in complete resolution of the ocular signs.

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Section: Outcome and Follow-upmentioning

confidence: 56%

Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection

et al. 2021

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“…Thymic epithelial cells can undergo abnormal differentiation and gradually form the anterior mediastinum tumor-THYM. The pathogenesis of THYM is complex and unclear, although certain viral infections have been reported to be associated with the tumorigenesis of THYM (Gong et al, 2019). However, the limited clinical specimens in prior studies made it difficult to conduct in- depth basic research linking the disease phenotype and genetic background.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Model of Eleven Genes Based on the Immune Microenvironment in Patients With Thymoma

Yang

Xie

et al. 2022

Front. Genet.

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Purpose: The pathogenesis of thymoma (THYM) remains unclear, and there is no uniform measurement standard for the complexity of THYM derived from different thymic epithelial cells. Consequently, it is necessary to develop novel biomarkers of prognosis estimation for patients with THYM.Methods: Consensus clustering and single-sample gene-set enrichment analysis were used to divide THYM samples into different immunotypes. Differentially expressed genes (DEGs) between those immunotypes were used to do the Kyoto Encyclopedia of Genes and Genomes analysis, Gene Ontology annotations, and protein-protein interaction network. Furthermore, the survival-related DEGs were used to construct prognostic model with lasso regression. The model was verified by survival analysis, receiver operating characteristic curve, and principal component analysis. Furthermore, the correlation coefficients of stemness index and riskscore, tumor mutation burden (TMB) and riskscore, drug sensitivity and gene expression were calculated with Spearman method.Results: THYM samples were divided into immunotype A and immunotype B. A total of 707 DEGs were enriched in various cancer-related or immune-related pathways. An 11-genes signature prognostic model (CELF5, ODZ1, CD1C, DRP2, PTCRA, TSHR, HKDC1, KCTD19, RFX8, UGT3A2, and PRKCG) was constructed from 177 survival-related DEGs. The prognostic model was significantly related to overall survival, clinical features, immune cells, TMB, and stemness index. The expression of some genes were significantly related to drug sensitivity.Conclusion: For the first time, a prognostic model of 11 genes was identified based on the immune microenvironment in patients with THYM, which may be helpful for diagnosis and prediction. The associated factors (immune microenvironment, mutation status, and stemness) may be useful for exploring the mechanisms of THYM.

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“…Thus, the putative lytic infection of retroviruses may have engaged in the occurrence of thymic disorder like thymoma in humans 28 . Furthermore, there have been studies demonstrating the presence of West nile virus (WNV), human polyomavirus 7 (HPyV7) and human parvovirus B19 (B19V) in thymoma or thymic hyperplasia 29–31 . The association of viruses with thymic epithelial tumors by these findings raises the possibility of the involvement of viruses in the development of thymoma.…”

Section: Viral Infection In the Pathogenesis Of Thymoma And Related Diseasesmentioning

confidence: 99%

Viral infection in thymoma and thymic tumors with autoimmune diseases

Chang

Duan

et al. 2021

Thoracic Cancer

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A thymoma is a type of thymic tumor which is rarely malignant that is frequently reported in adult patients. A number of thymoma‐related immune disorders are observed including autoimmune diseases, which suggests a strong connection between thymoma development and immunological mechanisms. Characterized by association with humoral and cellular immunodeficiency, thymoma patients are susceptible to opportunistic infections by environmental factors. Recent reports have suggested that viral infection may play a role in the etiological mechanisms of thymoma development associated with dysregulated immunity. In this review, we summarize the case reports and studies related to viral infection, such as CMV, EBV and HSV, that probably play a part in the pathogenesis of thymoma and related diseases. Furthermore, we demonstrate the underlying mechanisms by which viruses may induce the occurrence of thymoma with autoimmune diseases. Lastly, we discuss the potential application of antiviral therapy in the treatment of thymic diseases.

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Detection of human parvovirus B19 infection in the thymus of patients with thymic hyperplasia-associated myasthenia gravis

Cited by 14 publications

References 26 publications

Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection

Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection

Prognostic Model of Eleven Genes Based on the Immune Microenvironment in Patients With Thymoma

Viral infection in thymoma and thymic tumors with autoimmune diseases

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