Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Slaughter, Gymama; Kulkarni, Tanmay

doi:10.3390/en12050825

Cited by 16 publications

(9 citation statements)

References 32 publications

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“…The performance of the EFC was evaluated in air-saturated phosphate buffer containing 6 mM glucose. The fuel cell generated an open circuit potential of 413 ± 13 mV ( n = 3) that corresponds to the difference between the onset potentials for the reactions occurring at the cathode and the anode and aligns with previously reported glucose fuel cells . The fuel cell was subjected to a series of external resistance loads to obtain the polarization curve and the power-density profile of the fuel cell (Figure a).…”

Section: Resultssupporting

confidence: 80%

“…The fuel cell generated an open circuit potential of 413 ± 13 mV ( n = 3) that corresponds to the difference between the onset potentials for the reactions occurring at the cathode and the anode and aligns with previously reported glucose fuel cells. 37 The fuel cell was subjected to a series of external resistance loads to obtain the polarization curve and the power-density profile of the fuel cell ( Figure 5 a). The polarization curve shows a steady decrease in voltage with a short-circuit-current density of ca.…”

Section: Resultsmentioning

confidence: 99%

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Self-Powered Detection of Glucose by Enzymatic Glucose/Oxygen Fuel Cells on Printed Circuit Boards

Gonzalez-Solino

Bernalte

Royo

et al. 2021

ACS Appl. Mater. Interfaces

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Monitoring glucose levels in physiological fluids can help prevent severe complications associated with hypo- and hyper-glycemic events. Current glucose-monitoring systems require a three-electrode setup and a power source to function, which can hamper the system miniaturization to the patient discomfort. Enzymatic fuel cells (EFCs) offer the opportunity to develop self-powered and minimally invasive glucose sensors by eliminating the need for an external power source. Nevertheless, practical applications demand for cost-effective and mass-manufacturable EFCs compatible with integration strategies. In this study, we explore for the first time the use of gold electrodes on a printed circuit board (PCB) for the development of an EFC and demonstrate its application in saliva. To increase the specific surface area, the PCB gold-plated electrodes were modified with porous gold films. At the anode, glucose oxidase is immobilized with an osmium redox polymer that serves as an electron-transfer mediator. At the cathode, bilirubin oxidase is adsorbed onto the porous gold surface with a blocking agent that prevents parasitic reactions while maintaining the enzyme catalytic activity. The resulting EFC showed a linear response to glucose in phosphate buffer within the range 50 μM to 1 mM, with a sensitivity of 14.13 μA cm –2 mM –1 . The sensor was further characterized in saliva, showing the linear range of detection of 0.75 to 2 mM, which is within the physiological range, and sensitivity of 21.5 μA cm –2 mM –1 . Overall, this work demonstrates that PCBs are suitable platforms for EFCs, paving the way for the development of fully integrated systems in a seamless and miniaturized device.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Self-Powered Detection of Glucose by Enzymatic Glucose/Oxygen Fuel Cells on Printed Circuit Boards

Gonzalez-Solino

Bernalte

Royo

et al. 2021

ACS Appl. Mater. Interfaces

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“…In contrast, endogenous glucose production is a continuous process that is regulated depending on glucose physiological need; this need is established depending on body condition (fasting and fed states) [74]. Plasma is another source where glucose can be found in a concentration of about 6 mM [75]. Plasma glucose homeostasis is maintained in healthy people by a balance with endogenous and dietary glucose.…”

Section: Fuel Availabilitymentioning

confidence: 99%

Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices

et al. 2020

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This article consists of a review of the main concepts and paradigms established in the field of biological fuel cells or biofuel cells. The aim is to provide an overview of the current panorama, basic concepts and methodologies used in the field of enzymatic biofuel cells, as well as the applications of these bio-systems in flexible electronics and implantable or portable devices.Finally, the challenges needing to be addressed in the development of biofuel cells capable of supplying power to small size devices with applications in areas related to health and well-being or next generation portable devices are analyzed. The aim of this study is to contribute to biofuel cell technology development; this is a multidisciplinary topic about which review articles related to different scientific areas, from Materials Science to technology applications, can be found. With this article the authors intend to reach a wide readership in order to spread biofuel cell technology for different scientific profiles and boost new contributions and developments to overcome future challenges.

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“…Fuels such as methanol and ethanol have been studied for various purposes, but glucose has not. Recently, glucose has been investigated for various medical applications, considering its convenience, economic feasibility, biocompatibility, and eco‐friendliness compared to batteries [2–6] . Glucose is a nontoxic, nonflammable, and endogenous compound in body fluids with good biocompatibility [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Flow Channel Architecture and Diffusion Characteristics of Nonenzymatic Electrochemical Glucose Fuel Cells with Proton Exchange Membrane

et al. 2022

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A nonenzymatic glucose fuel cell directly oxidizes glucose to gluconic acid as a Pt‐based abiotic catalyst in a proton exchange membrane environment and has various advantages (e. g., biocompatibility, chemical stability, high ionic conductivity). We report the permeability of a less hydrophobic diffusion layer for three flow‐field designs (serpentine, interdigitated, and parallel). In all cases, as the channel width of the flow path increases, the power density increases and the Ohmic resistance decreases. The serpentine shape (channel and rib widths: 1.5 and 0.5 mm, respectively) exhibits remarkable maximum power and current densities (cell voltage: 60 mV) of 103.4 μW cm−2 and 1,273 μA cm−2 compared to those of the parallel (46.5 μW cm−2 at 683 μA cm−2) and interdigitated (74.0 μW cm−2 at 878 μA cm−2) shapes, respectively. Furthermore, permeability and performance analyses according to the single‐cell temperature, glucose concentration, and flow rate changes provide various perspectives on glucose fuel cells.

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Detection of Human Plasma Glucose Using a Self-Powered Glucose Biosensor

Cited by 16 publications

References 32 publications

Self-Powered Detection of Glucose by Enzymatic Glucose/Oxygen Fuel Cells on Printed Circuit Boards

Self-Powered Detection of Glucose by Enzymatic Glucose/Oxygen Fuel Cells on Printed Circuit Boards

Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices

Flow Channel Architecture and Diffusion Characteristics of Nonenzymatic Electrochemical Glucose Fuel Cells with Proton Exchange Membrane

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