Detection of Fusobacterium nucleatum in chorionic tissues of high‐risk pregnant women

Abstract

We suggest that F. nucleatum is detected in chorionic tissues of high-risk pregnant women, but not in chorionic tissues of normal pregnant women, and that F. nucleatum induces IL-6 and CRH production via both TLR-2 and TLR-4 in chorion-derived cells.

Functional Toll-like receptors in primary first trimester trophoblasts

“…The LPS-induced cytokine response in primary first trimester trophoblasts corresponds with 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 17 findings in other studies (Abrahams et al, 2005, Anton et al, 2012, and TLR4-mediated inflammation is shown associated with PTB in humans (Tateishi et al, 2012) and fetal growth restriction and PE-like symptoms in rats (Cotechini et al, 2014).Whereas primary trophoblasts responded to the TLR2/1 ligand, stimulation with the TLR2/6 ligand failed to induce and equivalent response, reflecting the complexity of the TLR2 signaling system. In trophoblast cell lines, a role for TLR6 in regulating the TLR2/1-response towards cytokine release has been suggested (Abrahams et al, 2008).…”

Are Periodontal Bacterial Profiles and Placental Inflammatory Infiltrate in Pregnancy Related to Birth Outcomes?

“…As in the case of the present study, this bacterium was not detected in all of the samples studied. In a recent study, periodontal pathogens, such as F. nucleatum , P. intermedia , T. forsythia , A. actinomycetemcomitans , and Treponema denticola , were detected in some oral samples from high‐risk pregnant females and normal pregnant females, whereas F. nucleatum alone was detected in chorionic tissues from high‐risk pregnant females 28 . Hence, the detection of one or several species in the gingival sulcus of pregnant females does not necessarily imply their presence in the placenta.…”

Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoEnull Mice

“…nucleatum is associated with more systemic diseases than other known periodontal pathogens, and has been isolated from more than 10 sites of systemic infection [14], and infection with F . nucleatum has been linked to development of colon cancer [9–12], adverse pregnancy outcomes [27,28], arterial atherosclerotic plaque growth [7], as well as dementia and brain abscess [14]. The exact role that PD and periodontal pathogens, specifically F .…”