Detection of Helicobacter pylori in Oral Lichen Planus and Oral Lichenoid Reaction

Abstract

Background: Oral Lichen Planus (OLP) is a chronic inflammatory disease affecting the oral mucosa in 0.5-2% of the world's population. It is more common in women compared to men and the mean age at the onset of the lesion is the fourth decade. Objectives: The purpose of this study was to evaluate the presence of Helicobacter pylori (H. pylori) in Oral Lichen Planus and Oral Lichenoid Reaction. Materials and Methods: A total of 41 biopsies diagnosed as Oral Lichen Planus and Oral Lichenoid Reaction and 15 samples as the control group were selected from the archives of Pathology Department of Loghman Hakim Hospital, Tehran, Iran from 2002 to 2009. All the paraffin blocks were cut for hematoxylin and eosin (H and E) staining to confirm the diagnoses and the samples were then prepared for immunohistochemistry (IHC) staining. Statistical analysis was performed using SPSS statistical software (version 21.0), the chi-squared test and Fisher's exact test, and independent-samples t test. Statistical significance between the groups was set at P < 0.05. Results: The H. pylori positivity was found in 29.7% and 14.8% of OLP, and OLR samples, respectively. Statistically significant difference was not observed compared to normal tissues (P = 0.661). The chi-squared test show no significant difference between the frequency of H. pylori positivity and the lesion type, gender, and site. Although H. pylori positivity was found in 59.2%, and 50 % of OLP, and OLR samples, respectively, statistically significant difference was not observed compared to normal tissues (P = 0.838). In addition, the chi-squared test show no significant difference between the site of the lesion and H. pylori positivity. H. pylori positivity was mostly found on the buccal mucosa (64.3%), however, H. pylori negativity was mostly found on the tongue (60 %) (P = 0.309). Additionally, the chi-squared test show no significant difference between the frequency of H. pylori positivity, and the gender (P = 0.517). Independent-samples t test showed no statistically significant difference between age and two patient groups statistically (P = 0.450).Conclusions: This present study reveals no significant difference between the presence of H. pylori in OLPs and OLRs. Yet, further studies with larger sample size needs to be done to prove this association.

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

“…Other regions include the tonsils and dorsal mucosa of the tongue. 15,37 Many studies based on genetic or serological tests in H. pylori detection have shown the presence of this bacterium in the oral cavity or stomach, while the number of studies demonstrating the effective isolation of this microbe from the oral environment is still very low. Hirsch et al 23 successfully managed to isolate live H. pylori from samples taken from dental canals.…”

The Association Between Helicobacter pylori Infection and Rosacea

“…Birth in developing countries is correlated with higher rates of infection, specifically crowded living conditions and poor socioeconomics (14). It seems that these bacteria are typically transferred through same age groups in families, yet then to the other members (15). Recent evidences suggest the principle role for H. pylori in dermatological problems, including Reynaud, rosacea, and urticarial rosacea, which is a chronic skin condition with frequent episodic characteristics, such as flushing, skin erythema, papulopustules, and skin telangiectasias (16,17).…”

Dysplastic change rate in cases of oral lichen planus: A retrospective study of 112 cases in an Iranian population

“…[ 3 ] The etiology of OLP is not clear, but immune dysregulation has been proposed to explain pathogenesis. [ 4 ] The most characteristic clinical feature of OLP is the presence of reticular white striations and/or white papules. In addition, plaque-type, atrophic/erosive, ulcerative and bullous lesions may be present at the time of diagnosis.…”