Detection of <i>NUP214-ABL1</i> translocation using <i>BCR-ABL1</i> dual color FISH probes in T-cell acute lymphoblastic leukemia–;an illustrative report and review of literature

Virk, Harpreet; Sreedharanunni, Sreejesh; Palla, Swetha; Rastogi, Pulkit; Rathore, Shailja; Anshu, Anshu; Trehan, Amita

doi:10.5045/br.2022.2022134

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…FISH can be used to map loci on specific chromosomes and its sensitivity can detect structural chromosomal rearrangements and numerical abnormalities [ 5 , 6 , 30 ]. They can be used to identify entire chromosomes using whole-chromosome painting probes, which can help identify karyotypes with complex translocations or marker chromosomes [ 5 ].…”

Section: Conventional Cytogenetic Diagnostic Assaysmentioning

confidence: 99%

Genomic technologies for detecting structural variations in hematologic malignancies

Jang

2024

Blood Res.

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Genomic structural variations in myeloid, lymphoid, and plasma cell neoplasms can provide key diagnostic, prognostic, and therapeutic information while elucidating the underlying disease biology. Several molecular diagnostic approaches play a central role in evaluating hematological malignancies. Traditional cytogenetic diagnostic assays, such as chromosome banding and fluorescence in situ hybridization, are essential components of the current diagnostic workup that guide clinical care for most hematologic malignancies. However, each assay has inherent limitations, including limited resolution for detecting small structural variations and low coverage, and can only detect alterations in the target regions. Recently, the rapid expansion and increasing availability of novel and comprehensive genomic technologies have led to their use in clinical laboratories for clinical management and translational research. This review aims to describe the clinical relevance of structural variations in hematologic malignancies and introduce genomic technologies that may facilitate personalized tumor characterization and treatment.

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Section: Conventional Cytogenetic Diagnostic Assaysmentioning

confidence: 99%

Genomic technologies for detecting structural variations in hematologic malignancies

Jang

2024

Blood Res.

View full text Add to dashboard Cite

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Detection of NUP214-ABL1 translocation using BCR-ABL1 dual color FISH probes in T-cell acute lymphoblastic leukemia–;an illustrative report and review of literature

Abstract: BCR-ABL1 dual color FISH probes in T-cell acute lymphoblastic leukemia -an illustrative report and review of literature. Blood Res 2022.

Cited by 1 publication

References 16 publications

Genomic technologies for detecting structural variations in hematologic malignancies

Genomic technologies for detecting structural variations in hematologic malignancies

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