Detection of<i>“Rickettsia amblyommii”</i>in Association with a Tick Bite Rash

Billeter, Sarah A.; Blanton, Hunter L.; Little, Susan E.; Levy, Michael G.; Breitschwerdt, Edward B.

doi:10.1089/vbz.2007.0121

Cited by 89 publications

(58 citation statements)

References 10 publications

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“…15 However, a North Carolina woman did develop rash at the site of the bite from an R. amblyommii-positive tick. 16 Similarly, in this study, we observed a sample with strong reactivity to R. amblyommii as confirmed by IFA and western blotting obtained from a patient who did not have fever but experienced rash and the development of an eschar. In comparison with R. rickettsii infection, where fever, headache, and rash are common, infection with R. amblyommii does not necessarily lead to the development of fever and the occurrence of rash is less likely.…”

Section: Discussionsupporting

confidence: 78%

“…In addition, R. amblyommii was detected in a tick that subsequently caused rash at the bite site in a patient, although no other symptoms developed. 16 Furthermore, tick surveys conducted in Tennessee have not detected R. rickettsii but R. amblyommii, R. parkeri, and R. montanensis were commonly found. 5,10 Similarly, tick surveys conducted in neighboring states in the southeastern region revealed the same pattern of the predominance of R. amblyommii in Amblyomma americanum ticks, the most ubiquitous and aggressive tick species in this region.…”

Section: Discussionmentioning

confidence: 99%

“…In North Carolina, sera from probable cases of RMSF demonstrated greater titers for R. amblyommii than R. rickettsii, and R. amblyommii DNA has been sequenced from a tick that caused a rash in a patient. 15,16 Although seroprevalence studies of SFG rickettsial infection in the United States have been performed in the past, 17,18 there have been limited attempts to determine if SFG rickettsiae other than R. rickettsii are contributing to the increase incidence of SFG rickettsiosis. In this study, we investigated serologic human exposure to four SFG rickettsiae in Tennessee: R. rickettsii, R. montanensis, R. parkeri, and R. amblyommii.…”

Section: Introductionmentioning

confidence: 99%

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Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee

Delisle¹,

Mendell²,

Stull-Lane³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Rocky Mountain spotted fever is the most common tick-borne disease in Tennessee. However, Rickettsia rickettsii has rarely been isolated from endemic ticks, suggesting rickettsioses may be caused by other species. A total of 56 human serum samples that were serologically positive for exposure to Rickettsia were obtained from commercial laboratories in 2010 and 2011. In addition, 20 paired sera from patients with encephalitis and positive Rickettsia serology were obtained from the Tennessee Unexplained Encephalitis Surveillance (TUES) study. Using an immunofluorescence assay, reactivity of the sera to R. rickettsii, Rickettsia montanensis, Rickettsia parkeri, and Rickettsia amblyommii was tested, and a comparison of endpoint titers was used to determine the probable antigen that stimulated the antibody response. Cross-absorption was conducted for 94.8% (N = 91) of the samples due to serologic cross-reactivity. Of the commercial laboratory samples, 55.4% (N = 31) had specific reactivity to R. amblyommii and 44.6% (N = 25) were indeterminate. Of the paired TUES samples, 20% (N = 4) had specific reactivity to R. amblyommii, 5% (N = 1) to R. montanensis, and 5% (N = 1) to R. parkeri. Patients with specific reactivity to R. amblyommii experienced fever (75%), headache (68%) and myalgia (58%). Rash (36%) and thrombocytopenia (40%) were less common. To our knowledge, this is the first time R. amblyommii has been reported as a possible causative agent of rickettsioses in Tennessee.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee

Delisle¹,

Mendell²,

Stull-Lane³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…In 2007 it was temporally associated with a macular rash when it was detected in an A. americanum removed from a patient. 30 More recently, a group in North Carolina obtained serum samples from patients considered probable cases of RMSF and found that some of the patients had higher end-point titers against R. amblyommii antigen than R. rickettsii . 11 In our study, the most common rickettsial species in all sexes and stages of ticks was R. amblyommii .…”

Section: Discussionmentioning

confidence: 99%

Absence of Rickettsia rickettsii and Occurrence of Other Spotted Fever Group Rickettsiae in Ticks from Tennessee

Moncayo¹,

Cohen²,

Fritzen³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Rocky Mountain spotted fever (RMSF) is the most common tick-borne illness in Tennessee. Little is known about the occurrence of R. rickettsii, the causative agent, in ticks in Tennessee. To better understand the prevalence and distribution of rickettsial agents in ticks, we tested 1,265 Amblyomma, Dermacentor, and Ixodes adult and nymphal ticks. Additionally, we tested 231 Amblyomma americanum larvae. Ticks were collected from 49 counties from humans, wild animals, domestic canines, and flannel drags. Spotted fever group rickettsiae (SFGR) DNA was detected by polymerase chain reaction (PCR) in 32% of adult and nymphal ticks. A total minimum infection rate of 85.63 was found in larval pools tested. Three rickettsial species, Rickettsia montana, Rickettsia amblyommii, and Rickettsia cooleyi were identified by molecular analysis. Rickettsia rickettsii was not detected. This study suggests that some RMSF cases reported in Tennessee may be caused by cross-reactivity with other SFGR antigenically related to R. rickettsii.

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“…The etiology is still being investigated. One report suggested that R. amblyommii could be the cause of STARI, but the description of the rash did not seem consistent with EM; no photograph was included, and only one case was presented [35]. A Georgia study [12] reported EM rashes on two persons bitten by lone star ticks positive for R. amblyommii, but this does not preclude the rashes being caused by another agent.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Case Reports of Two Central North Carolina Residents

Herman-Giddens

2017

North Carolina Medical Journal

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Detection of“Rickettsia amblyommii”in Association with a Tick Bite Rash

Cited by 89 publications

References 10 publications

Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee

Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee

Absence of Rickettsia rickettsii and Occurrence of Other Spotted Fever Group Rickettsiae in Ticks from Tennessee

Retrospective Case Reports of Two Central North Carolina Residents

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