Detection of IgM against Dengue Virus in Clinically Suspected Patients Presenting at a Tertiary Care Centre, Narayani Zone, Nepal

Nepal, Hari Prasad; Ansari, Shamshul; Gyawali, Narayan; Gautam, Rajendra; Paudel, Raju; Shrestha, Sony; Rimal, Brihaspati; Acharya, A; Chapagain, Moti; Taylor‐Robinson, Andrew W.

doi:10.4172/2329-891x.1000139

Cited by 10 publications

(12 citation statements)

References 29 publications

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“…However, few other studies show a slightly higher male preponderance. 11, 15 We could not find any paediatric preponderance in our study. Adults were more commonly affected than children.…”

Section: Discussioncontrasting

confidence: 60%

Hospital-Based Seroprevalence Among Suspected Cases of Dengue in a Tertiary Care Hospital

Belurkar¹,

Sharma²,

Sule³

2017

jemds

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BACKGROUNDDengue has been one of the most important public health issues in tropical and subtropical regions of the world due to the spread of the vector infestation in domestic environments and the potential of dengue virus infection to cause successive epidemics in highly urbanised settings. This retrospective observational study was undertaken to determine the occurrence of dengue in clinically suspected patients in and around Thane so as to be able to formulate strategies to combat this menace. MATERIALS AND METHODSBlood samples were collected from 1986 clinically suspected Dengue Fever (DF) or Dengue Haemorrhagic Fever (DHF) cases attending a tertiary care health centre in a metropolitan city from September 2015 to August 2016. Sera were tested for dengue specific IgM and IgG antibodies by immunochromatographic strip. RESULTSOut of 1986 patients, 479 were seropositive for dengue antibodies, prevalence being 24.12%. Amongst seropositive cases, 46.35% were IgM positive. Besides these, 31.73% were also positive for both IgM and IgG while 21.92% were only IgG positive. CONCLUSIONDengue is becoming an emerging problem in Thane. Hence, diagnosis at an early stage is the effective strategy to control disease progression. KEYWORDSDengue, Dengue Fever (DF), Dengue Haemorrhagic Fever (DHF), IgM, IgG, Prevalence. HOW TO CITE THIS ARTICLE:Belurkar DD, Sharma PC, Sule PA. Hospital-based seroprevalence among suspected cases of dengue in a tertiary care hospital.

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“…However, few other studies show a slightly higher male preponderance. 11, 15 We could not find any paediatric preponderance in our study. Adults were more commonly affected than children.…”

Section: Discussioncontrasting

confidence: 60%

Hospital-Based Seroprevalence Among Suspected Cases of Dengue in a Tertiary Care Hospital

Belurkar¹,

Sharma²,

Sule³

2017

jemds

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“…dengue hemorrhagic fever/ dengue shock syndrome (DHF/DSS) which is considered to be linked with Antibody dependent enhancement 5 . The disease is characterized by high grade fever with headache, retro-orbital pain, low back pain, skin rash, muscle or joint pain and bleeding manifestations 6 .…”

Section: Introductionmentioning

confidence: 99%

Frequency of dengue infection in febrile patients attended Dhaka Medical College Hospital during January to December, 2018

et al. 2020

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Introduction: Dengue is a major public health concern in our country. The alarming thing is that the seasonal trend of dengue infection is changing with time in Bangladesh due to climate change and unplanned urbanization. Our study was conducted to determine the frequency of dengue virus infection among the febrile patients in 2018 at Dhaka Medical College Hospital (DMCH) and to observe the seasonal trend. Materials and Methods: The study was carried out on 899 febrile patients attended in DMCH from January to December, 2018. Whole blood samples were collected and sera were tested for dengue NS1 antigen and anti-dengue IgM antibodies using commercial test kits (NS1 by OMC Healthcare (Pvt.) Ltd & IgM antibody by Omega Diagnostics Ltd.), respectively. All negative dengue cases were tested for anti Chikungunya antibody to exclude chikungunya. Results: Of the total 899 febrile patients, 350(38.93%) were positive for Dengue infection. Out of them 264(75.43%) were positive for NS1, 82 (23.43%) were positive for IgM and 4 (1.14%) were positive for dengue NS1antigen + anti dengue IgM antibody. More than 50% patients belonged to age group 15-29 years. Males were predominant. More than 60% cases were detected in the post monsoon season. Conclusion: Highest dengue cases were detected in this year in comparison to the previous year’s probably due to re-emergence of DEN-3 serotype. Due to pattern of climate change, seasonal trend of dengue infection was not maintained. Moreover, unplanned urbanization and poor solid waste management have worsened the situation more. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 105-111

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“…Increased travel and trade is an impact of globalization, which are significant considerations for enhanced dengue transfer. Travel and tourism are important problems in the context of dengue transmission, as it is believed that the movement of dengue-infected people is a major driver of worldwide disease development (Nepal et al, 2014).…”

Section: Epidemiology and Outbreakmentioning

confidence: 99%

Review on current status of dengue and its prevention in India

Sukumaran¹,

Tom²,

Kandasamy³

et al. 2019

ijrps

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Dengue is an acute viral infection with potential deadly complications transmitted by both Aedes aegypti and Aedes albopictus female mosquitoes and is said to be a severe and increasing public health problem with 2.5 billion individuals at risk. WHO currently estimates that with around 24,000 fatalities, 50 million cases of dengue disease may occur globally once a year. In India, too, the condition is getting worse as morbidity and mortality rise. Several policies have been adopted to decrease dengue burden through applied research, field-based training, and capacity building among appropriate regional and national public health stakeholders.

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Detection of IgM against Dengue Virus in Clinically Suspected Patients Presenting at a Tertiary Care Centre, Narayani Zone, Nepal

Cited by 10 publications

References 29 publications

Hospital-Based Seroprevalence Among Suspected Cases of Dengue in a Tertiary Care Hospital

Hospital-Based Seroprevalence Among Suspected Cases of Dengue in a Tertiary Care Hospital

Frequency of dengue infection in febrile patients attended Dhaka Medical College Hospital during January to December, 2018

Review on current status of dengue and its prevention in India

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