Detection of IL-20 and its receptors on psoriatic skin

Wei, Chang-Ching; Chen, Wei Yu; Wang, Yo Ching; Chen, Po‐Jen; Lee, Julia Yu Yun; Wong, Tak Wah; Chen, Wen Chieh; Wu, Jen Chin; Chen, Guan Ying; Chang, Ming Shi; Lin, Yu Tzu

doi:10.1016/j.clim.2005.06.012

Cited by 101 publications

(122 citation statements)

References 17 publications

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“…7,8,10,16 Psoriatic lesions are characterized by increased expression of IL-19 and IL-20, which is normalized after treatment with cyclosporine or calcipotriol parallel to the clinical improvement of psoriatic lesions. 7,8 Although the data on the expression of IL-20R types I and II in psoriasis are somewhat controversial it seems possible that changes in the expression and/or function of IL-20-RI contribute to the changes of the IL-19 cytokine system that are part of psoriasis pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

“…10 However, when lesional skin was compared to nonlesional skin of patients with psoriasis, the expression levels of IL-20RA and IL-20RB were higher in the latter, 8,23 whereas expression of IL-22RA1 levels was comparable. 23 The factors that regulate the expression of IL-20R subunits are unclear.…”

Section: Introductionmentioning

confidence: 97%

“…[4][5][6] The expression levels of IL-19, IL-20 and IL-24 in lesional skin of psoriasis patients are increased compared to healthy skin. 2,[7][8][9][10][11] Two independent studies have demonstrated that overexpression of IL-20 in transgenic mice induces a skin phenotype similar to psoriasis. 2,5 Both in vitro and in vivo, IL-20 promotes hyperproliferation and abnormal differentiation of keratinocytes that are characteristic features of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Association analysis of IL20RA and IL20RB genes in psoriasis

et al. 2008

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The interleukin-20-receptor I complex (IL-20-RI) is composed of two chains, IL20RA and IL20RB. Its ligands are the three members of the IL19 subfamily of cytokines, . These cytokines are important in the manifestation of psoriatic lesions and, recently, an association of polymorphisms of IL20 with psoriasis has been described. In the present study we tested the hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and investigated single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients (n ¼ 254) and healthy controls (n ¼ 224). We found no association of any of the investigated SNPs with the disease. Analysis of pairwise linkage disequilibrium (LD) across studied markers revealed a strong level of LD between SNPs within the IL20RA gene and SNPs within the IL20RB gene, and, for both genes six common haplotypes were identified with an estimated frequency X1%. Haplotype analyses suggested that the IL20RA haplotype CCG (rs1184860, rs1167846, rs1167849) is significantly associated with psoriasis (OR 3.14, 95% CI 1.61-6.14), whereas the TTG haplotype had a protective effect (OR 0.20, 95% CI 0.07-0.55). The risk haplotype defining SNPs 1167846 and 1184860 were found to modify paired box 5 and homeobox A9 sites, respectively, two transcription factors related to the differentiation of immune cells. Further studies are needed to confirm the genetic association and to investigate the functional relevance of IL20RA haplotypes in psoriasis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Association analysis of IL20RA and IL20RB genes in psoriasis

et al. 2008

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“…Immunohistochemical staining was used to confirm mIL-20R1a and MCP-1 expression in the kidneys from the FvB control mice and mIL-20R1a transgenic mice as previously described. 54 …”

Section: Lactate Dehydrogenase Assaymentioning

confidence: 99%

“…5 Within this subfamily, IL-19, IL-20 and IL-24 share receptor complexes; 6 all of them are capable of signaling through IL-20R1/IL-20R2 and IL-20 and IL-24 can also use IL-22R/ IL-20R2. 6 Because a growing number of studies have revealed the association of IL-19, 7-9 IL-20 8,[10][11][12][13][14][15][16] and IL-24 [17][18][19][20][21][22] with diseases, the identification of soluble proteins derived from the genes of the functional receptors may provide more insights into the biomolecular mechanisms of their functions.…”

Section: Introductionmentioning

confidence: 99%

Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition

Wei

Chang

2008

Genes Immun

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We previously identified a novel transcript, mouse (m)IL-20R1a, generated by alternative splicing of the mIL-20R1 gene and studied its possible in vitro functions. However, the function of mIL-20R1a in vivo is unknown. Overexpression of mIL-20R1a in transgenic FvB/N mice resulted in the pathological change of excess calcium deposited in the kidneys. The interplay between renal epithelial cells and calcium oxalate (CaOx) was important in the crystallization involved in the formation of renal stones (nephrolithiasis). Thus, we investigated and compared the responses of mouse renal proximal (TKPTS) and collecting (M-1) tubule cell lines to CaOx with or without mIL-20R1a. The renal epithelial cell lines exposed to CaOx in the presence of mIL20R1a showed significantly increased lactate dehydrogenase release; loss of cell viability through apoptosis; increased CaOx internalization; higher tumor necrosis factor (TNF)-a, MCP-1 and RANTES expression; and higher reactive oxygen species production. Interleukin-6, TNF-a and MCP-1 were also upregulated in the kidneys of mIL-20R1a transgenic mice. These effects of mIL-20R1a on CaOx-exposed renal epithelial cells showed that mIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice.

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MAbs Targeting Soluble Mediators in Phase 1 and 2 Clinical Studies Immunological Disorders

Brennan

2014

Handbook of Therapeutic Antibodies

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Detection of IL-20 and its receptors on psoriatic skin

Cited by 101 publications

References 17 publications

Association analysis of IL20RA and IL20RB genes in psoriasis

Association analysis of IL20RA and IL20RB genes in psoriasis

Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition

MAbs Targeting Soluble Mediators in Phase 1 and 2 Clinical Studies Immunological Disorders

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