Detection of inorganic ions on a capillary electrophoresis microchip using a conductivity technique

Petkovic-Duran, Karolina; Zhu, Yonggang; Swallow, Anthony; Noui-Mehidi, N.; Leech, Patrick W.; Glenn, F.L.

doi:10.1117/12.695682

Cited by 5 publications

(5 citation statements)

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“…Figure 3 shows the simplest design which has two metal electrodes placed onto capping layer of PC microchip 10,11 . After an AC signal (316kHz, 8V) is applied to the drive electrode, current passes the capping layer, the detection gap between the electrodes, and back to the pick-up electrode.…”

Section: Contactless Conductivity Detector (Ccd)mentioning

confidence: 99%

Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products

et al. 2008

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This paper reports on the development of a hand-held device for on-site detection of organophosphonate nerve agent degradation products. This field-deployable analyzer relies on efficient microchip electrophoresis separation of alkyl methylphosphonic acids and their sensitive contactless conductivity detection. Miniaturized, low-powered design is coupled with promising analytical performance for separating the breakdown products of chemical warfare agents such as Soman, Sarin and VX . The detector has a detection limit of about 10 μg/mL and has a good linear response in the range 10-300 μg/mL concentration range. Applicability to environmental samples is demonstrated .The new hand-held analyzer offers great promise for converting conventional ion chromatography or capillary electrophoresis sophisticated systems into a portable forensic laboratory for faster, simpler and more reliable on-site screening.

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Section: Contactless Conductivity Detector (Ccd)mentioning

confidence: 99%

Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products

et al. 2008

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“…A simple two electrode design of the CCD sensor array was used for this work [19]. The conductivity detector electronic circuit was implemented according to the design of Da Silva et al [20].…”

Section: Contactless Conductivity Detection (Ccd)mentioning

confidence: 99%

Identification of chemical warfare agents using a portable microchip-based detection device

et al. 2011

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Analysis of chemical warfare agents (CWAs) and their degradation products is an important verification component in support of the Chemical Weapons Convention and urgently demanding rapid and reliable analytical methods. A portable microchip electrophoresis (ME) device with contactless conductivity (CCD) detection was developed for the in situ identification of CWA and their degradation products. A 10mM MES/His, 0.4mM CTAB -based separation electrolyte accomplished the analysis of Sarin (GB), Tabun( GA) and Soman (GD) in less than 1 min, which is the fastest screening of nerve agents achieved with portable ME and CCD based detection methods to date. Reproducibility of detection was successfully demonstrated on simultaneous detection of GB (200ppm) and GA (278ppm). Reasonable agreement for the four consecutive runs was achieved with the mean peak time for Sarin of 29.15s, and the standard error of 0.58s or 2%. GD and GA were simultaneously detected with their degradation products methylphosphonic acid (MPA), pinacolyl methylphosphonic acid (PMPA) and O-Ethyl Phosphorocyanidate (GAHP and GAHP1) respectively. The detection limit for Sarin was around 35ppb. To the best of our knowledge this is the best result achieved in microchip electrophoresis and contactless conductivity based detection to date.

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“…CCD detectors continue to be the preferred choice due to their low cost, simplicity to handle and flexible measurement scheme 18. The detector electrodes could be attached on the chip bottom surface 129, assembled on an independent (and replaceable) plate 130 or similarly as a part of the chip holder 131, screen‐printed or thin‐film configured 132. Sensitivity of CCD can be substantially improved by reducing the electrode impedance, e.g .…”

Section: Microchip Electrophoresis: On the Way To Routine Usementioning

confidence: 99%

“…The favored materials for microchip fabrication (including commercially available chips) encompass various polymers, e.g . PMMA 131, 132, 140, polycarbonate 106, 129, PDMS 135–138 or glass 130, 134, 137, 139, 141. There is a certain indication that PDMS substrate material may take a dominating place in prototyping microchip analytical devices, at least at a research stage.…”

Section: Microchip Electrophoresis: On the Way To Routine Usementioning

confidence: 99%

Inorganic species analysis by CE – An overview for 2007–2008

Timerbaev

2009

Electrophoresis

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This review article represents the sixth in a series of reviews on CE applied to inorganic analysis, appearing in this journal, and focuses on material published in 2007-2008. As a fundamental review, it examines primarily those documents in which the emphasis is on advances in general CE methodology which are traditionally set on the attainment of higher detection sensitivity and greater preconcentration factors both in capillary and microchip separation formats. Following a major research trend of the previous review period (see A.R. Timerbaev, Electrophoresis 2007, 28, 3420-3425), publications focusing on the quantification of different element species continue to rapidly outpace other applications. A range of practicable separation and detection designs tailor-made to species-selective analysis are critically discussed in order to assess their impact on the rate of development and wide acceptance of CE in the field.

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Detection of inorganic ions on a capillary electrophoresis microchip using a conductivity technique

Cited by 5 publications

References 0 publications

Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products

Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products

Identification of chemical warfare agents using a portable microchip-based detection device

Inorganic species analysis by CE – An overview for 2007–2008

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