Detection of Inosine Monophosphate (IMP) in Meat Using Double-Enzyme Sensor

Wang, Guangxian; Sun, Jianfei; Yao, Yao; An, Xingshuang; Zhang, Hui; Chu, Guanglei; Jiang, Shui; Guo, Yemin; Liu, Yuan

doi:10.1007/s12161-019-01652-y

Cited by 51 publications

(18 citation statements)

References 45 publications

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“…[64] The sensor showed a linear correlation with the urea concentration in the range of 0-3 × 10 −3 m and an LOD of 0.02 × 10 −3 m. Furthermore, an electrocatalytic redox reaction between the terminal group of MXenes and a copper ion-creatinine chelated complex enabled detection of creatinine. As a result, the sensor showed a linear correlation with the creatinine concentration in the range of 10-400 × 10 −6 m and an LOD of 1.2 × 10 −6 m. Additionally, high-sensitivity sensors based on a variety of enzymes for the detection of various analytes such as pesticides, [65,66] nutrients, [67][68][69][70] and metabolic by-products [63,71,72] have been reported. In addition to enzyme-based biosensors, MXenebased aptasensors using aptamers have been studied.…”

Section: Electrochemical Biosensorsmentioning

confidence: 95%

Sensing with MXenes: Progress and Prospects

et al. 2021

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conventional technology is gradually reaching its limits in terms of further enhancement of sensor performance. Hence, tremendous efforts have been taken to explore the applicability of MXenes in various sensor technologies, including chemical, biological, mechanical, and optical sensors. The large specific surface area, high electrical conductivity, [1,2] and water dispersibility of MXenes, among their various excellent properties, constitute essential characteristics of a sensor material. Particularly, the 2D structure of MXene, which is conducive to functionalization using various terminal groups, provides a large number of active surface sites. These sites can serve as a highly responsive sensory platform for various external stimuli. Furthermore, the high electrical conductivity of MXenes is desirable for achieving low noise in sensory responses. Therefore, these characteristics demonstrate MXenes as a highly promising alternative sensor material for achieving high sensitivity, exceptionally low limit of detection (LOD), and minimum detectable amount of analytes in various sensor applications. Finally, the water dispersibility of MXenes facilitates environment-friendly fabrication and modification treatments; thus, they are further advantageous in processing.Because the fundamental properties of MXenes satisfy the requirements for an alternative sensor material, MXenebased sensor technology has been rapidly evolving over the last few years. The field of MXene-based sensors is facing conventional challenging problems as hurdles to commercialization: achieving reliably high performance, high stability, multifunctionality, and realizing homogeneous and reproducible scale-up processing (Figure 1a) of MXene-based sensors. Several recent studies on MXene-based sensors were aimed at establishing various structural and electrical approaches to utilize the excellent properties of MXene, thus boosting the sensor performance. For example, the macrostructuring of MXenes can significantly increase the sensitivity and lower the LOD of the resultant fabricated sensor. [3,4] Furthermore, the functionalization of MXene surfaces can impart useful properties of the secondary component to the MXene-based sensor to obtain higher performance than that of pristine MXenebased sensors. [5] These approaches have been highly effective and reliable, and thus significantly accelerated the progress of MXene-based sensor research. Figure 1b shows the network of co-occurring keywords in 2375 MXene-based research papers published since the discovery of MXenes in 2011. In an attempt to introduce new low-cost, high-performance, and Various fields of study consider MXene a revolutionary 2D material. Particularly in the field of sensors, the metal-like high electrical conductivity and large surface area of MXenes are desirable characteristics as an alternative sensor material that can transcend the boundaries of existing sensor technology. This critical review provides a comprehensive overview of recent advances in MXene-based sensor technology...

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Section: Electrochemical Biosensorsmentioning

confidence: 95%

Sensing with MXenes: Progress and Prospects

et al. 2021

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“…Based on the above composites, MXene‐Au @Pt/5′‐nucleotidase/xanthine oxidase/ bovine serum albumin (BSA) double‐enzyme biosensor is fabricated, and the qualitative and quantitative detection of inosine monophosphate (IMP) is achieved by the by‐product H 2 O 2 produced after enzymatic hydrolysis. [ 91 ]…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Progress and biomedical applications of MXenes

et al. 2021

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As a new kind of two‐dimensional material, MXene is first discovered in 2011. Because of its diverse chemical composition with excellent physical and chemical properties, the family of MXenes has attracted people's extensive research interest in various fields, such as energy storage, environment, catalysis and biomedical applications, among which the researches about biomedical applications are relatively more burgeoning than that in other fields. This review concludes the progress and biomedical applications of MXenes. Firstly, the development background of MXenes is introduced. Then, the synthesis methods, structures and properties, surface modification strategies, biomedical applications, cytotoxicity and biocompatibility of MXenes are demonstrated in each chapter successively. At last, the materials of MXenes are summarized, besides, the opportunities and challenges faced by MXenes in the future are prospected. This review will provide some help for the advancement and application of MXenes.

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“…Their biosensor was based on a three-dimensional (3D) MnO 2 /Mn 3 O 4 /MXene/AuNPs composite (Figure 1) possessing a low LOD of 0.134 pM toward methamidophos. Wang, G. X. et al [107]. assembled a dual-enzyme biosensor for the detection of inosine monophosphate (IMP).…”

Section: Enzyme-based Biosensorsmentioning

confidence: 99%

“…Wang, G. X. et al. [107]. assembled a dual‐enzyme biosensor for the detection of inosine monophosphate (IMP).…”

Section: Application Of Mxene In Electrochemical Sensorsmentioning

confidence: 99%

Application of MXene in Electrochemical Sensors: A Review

Sun

et al. 2021

Electroanalysis

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Electroanalysis has obtained considerable progress over the past few years, especially in the field of electrochemical sensors. Broadly speaking, electrochemical sensors include not only conventional electrochemical biosensors or non‐biosensors, but also emerging electrochemiluminescence (ECL) sensors and photoelectrochemical (PEC) sensors which are both combined with optical methods. In addition, various electrochemical sensing devices have been developed for practical purposes, such as multiplexed simultaneous detection of disease‐related biomarkers and non‐invasive body fluid monitoring. For the further performance improvement of electrochemical sensors, material is crucial. Recent years, a kind of two‐dimensional (2D) nanomaterial MXene containing transition metal carbides, nitrides and carbonitrides, with unique structural, mechanical, electronic, optical, and thermal properties, have attracted a lot of attention form analytical chemists, and widely applied in electrochemical sensors. Here, we reviewed electrochemical sensors based on MXene from Nov. 2014 (when the first work about electrochemical sensor based on MXene published) to Mar. 2021, dividing them into different types as electrochemical biosensors, electrochemical non‐biosensors, electrochemiluminescence sensors, photoelectrochemical sensors and flexible sensors. We believe this review will be of help to those who want to design or develop electrochemical sensors based on MXene, hoping new inspirations could be sparked.

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Detection of Inosine Monophosphate (IMP) in Meat Using Double-Enzyme Sensor

Cited by 51 publications

References 45 publications

Sensing with MXenes: Progress and Prospects

Sensing with MXenes: Progress and Prospects

Progress and biomedical applications of MXenes

Application of MXene in Electrochemical Sensors: A Review

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