Detection of intra-amniotic infection in a rabbit model by proteomics-based amniotic fluid analysis

Klein, Laura L.; Freitag, Breton C.; Gibbs, Ronald S.; Reddy, Ashok P.; Nagalla, Srinavasa R.; Gravett, Michael G.

doi:10.1016/j.ajog.2005.06.017

Cited by 20 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Early applications of proteomics in reproduction and development included the elucidation of biomarkers in amniotic fluid and maternal serum for intrauterine infection and premature rupture of membranes (Buhimschi et al, 2004; Buhimschi et al, 2005a–c; Gravett et al, 2004; Klein et al, 2005; Nilsson et al, 2004; Ruetschi et al 2005; Thadikkaran et al, 2005; Vuadens et al, 2003). More recent studies have investigated the proteome of semen (Li et al, 2007), identified semen biomarkers of varying fertility rates (Peddinti et al, 2008), and examined inter-individual variations in the seminal plasma proteome of fertile men (Yamakawa et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics in the assessment of chemical‐induced reproductive and developmental outcomes using non‐invasive biological fluids: application to the study of butylbenzyl phthalate

Sumner

Snyder²,

Burgess³

et al. 2009

J of Applied Toxicology

View full text Add to dashboard Cite

This study was conducted to evaluate the use of metabolomics for improving our ability to draw correlations between early life exposures and reproductive and/or developmental outcomes. Pregnant CD rats were exposed by gavage daily during gestation to vehicle or to butylbenzyl phthalate (BBP) in vehicle at a level known to induce effects in the offspring and at a level previously not shown to induce effects. Urine was collected for 24 h (on dry ice using all glass metabolism chambers) from dams on gestational day 18 (during exposure) and on post natal day (pnd) 21, and from pnd 25 pups. Traditional phenotypic anchors were measured in pups (between pnd 0 and pnd 26). Metabolomics of urine collected from dams exposed to vehicle or BBP exhibited different patterns for endogenous metabolites. Even three weeks after gestational exposure, metabolic profiles of endogenous compounds in urine could differentiate dams that received the vehicle, low dose, or high dose of BBP. Metabolic profiles could differentiate male from female pups, pups born to dams receiving the vehicle, low or high BBP dose, and pups with observable adverse reproductive effects from pups with no observed effects. Metabolites significant to the separation of dose groups and their relationship with effects measured in the study were mapped to biochemical pathways for determining mechanistic relevance. The application of metabolomics to understanding the mechanistic link between low levels of environmental exposure and disease/dysfunction holds huge promise, because this technology is ideal for the analysis of biological fluids (e.g., urine, serum) in human populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolomics in the assessment of chemical‐induced reproductive and developmental outcomes using non‐invasive biological fluids: application to the study of butylbenzyl phthalate

Sumner

Snyder²,

Burgess³

et al. 2009

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…One interesting pioneering study was performed in rabbits and allowed to detect intraamniotic infection by proteomic-based amniotic fluid analysis. 73 For human diseases or those of livestock, the biological fluid, which should enable the detection of infection, linked to host proteome response, in the host serum. Several studies performed on this biological sample have allowed discriminating host-commensal from hostepathogen interactions in Candida albicans 74 and determining the immunome of pathogens.…”

Section: Host Proteome Responses To Parasite Infectionmentioning

confidence: 99%

Proteomics and Host–Pathogen Interactions

Biron

Nedelkov

Missé

et al. 2017

Genetics and Evolution of Infectious Diseases

View full text Add to dashboard Cite

“…The PTD rate continues to rise, despite considerable efforts and progress towards defining the pathogenesis of preterm births and refining multimodal treatment strategies. Infection is reported to be responsible for 10–50% of PTDs, with higher rates being seen in underdeveloped countries . A wide variety of animal models have been described to investigate the mechanisms of PTD; direct comparisons between models are sometimes hampered by differences in species used, the agents used to initiate PTD and the route of inoculation or administration (see Table ).…”

Section: Immunological Aspects Of Infective Preterm Deliverymentioning

confidence: 99%

Immunology of infective preterm delivery in the mare

Lyle

2014

Equine Veterinary Journal

View full text Add to dashboard Cite

Placentitis is reported to be the cause of 9.8-33.5% of abortions, stillbirths and perinatal losses in horses. Bacterial infections are responsible for 53% of placentitis cases with Streptococcus equi ssp. zooepidemicus being isolated in 28% of these cases. Clinically, mares may have a vaginal discharge, show udder development, lactate prenatally and deliver a premature or dead foal. Major aspects of the pathogenesis of infectious preterm delivery that may require more effective therapeutic targeting are myometrial contraction, immunological aspects of preterm delivery, and the effects of proinflammatory cytokine signalling on activation of the fetal hypothalamic-pituitary-adrenal axis. This article focuses on current knowledge of inflammatory signalling secondary to equine placentitis, and the interplay among inflammation, loss of myometrial quiescence and activation of the fetal hypothalamic-pituitary-adrenal axis.

show abstract

Detection of intra-amniotic infection in a rabbit model by proteomics-based amniotic fluid analysis

Cited by 20 publications

References 22 publications

Metabolomics in the assessment of chemical‐induced reproductive and developmental outcomes using non‐invasive biological fluids: application to the study of butylbenzyl phthalate

Metabolomics in the assessment of chemical‐induced reproductive and developmental outcomes using non‐invasive biological fluids: application to the study of butylbenzyl phthalate

Proteomics and Host–Pathogen Interactions

Immunology of infective preterm delivery in the mare

Contact Info

Product

Resources

About