Detection of lunasin in quinoa (<i>Chenopodium quinoa</i> Willd.) and the <i>in vitro</i> evaluation of its antioxidant and anti‐inflammatory activities

Ren, Guixing; Zhu, Yingying; Shi, Zhenxing; Li, Jianhui

doi:10.1002/jsfa.8278

Cited by 56 publications

(49 citation statements)

References 25 publications

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“…The peptide also showed strong antitumor effect against stomach, cervical and breast cancer cell lines and stimulated the immune system [173]. Another recent study has shown that lunasin isolated from quinoa has strong anti-inflammatory and antioxidant abilities [174]. Since reactive oxygen species can cause inflammation [175], lunasin could be important in treating or preventing inflammatory diseases.…”

Section: Food-derived Bioactive Peptides and Human Healthmentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

423

254

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The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

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Section: Food-derived Bioactive Peptides and Human Healthmentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

423

254

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“…The green seaweed U. lactuca has been reported as a suitable low-energy, high-protein foodstuff for sheep and goats [172,173]. However, seaweed may be not be suitable for supplementation in pregnant ewes, having been reported to interfere with passive immunity in lambs and increasing mortality rate [174].…”

Section: Ruminantsmentioning

confidence: 99%

Food Proteins and Bioactive Peptides

2018

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“…The possible mechanisms of these effects could involve the modulation of cyclooxygenase‐2 (COX‐2), inducible nitric oxide synthase (iNOS), and nuclear factor (NF)‐κB pathways . Lunasin present in natural quinoa has also been found to inhibit the secretion of nitric oxide, TNF‐α and IL‐6 in RAW264.7 cells activated by LPS . Recently, it has been revealed that lunasin acts as a potential anti‐inflammatory agent not only in macrophages but also in adipocytes, disrupting the cross‐talk between these two cells, suggested that auxiliary prevention or therapy in obesity‐related inflammatory applications .…”

Section: Other Bioactivities Of Lunasinmentioning

confidence: 99%

“…93,94 Lunasin present in natural quinoa has also been found to inhibit the secretion of nitric oxide, TNF-and IL-6 in RAW264.7 cells activated by LPS. 95 Recently, it has been revealed that lunasin acts as a potential anti-inflammatory agent not only in macrophages but also in adipocytes, disrupting the cross-talk between these two cells, suggested that auxiliary prevention or therapy in obesity-related inflammatory applications. 96 Moreover, lunasin's anti-inflammatory activity possibly benefits its chempreventive activity in 4 T1 breast cancer cell cultured in the condition of inflammatory adipocyte.…”

Section: Antioxidant and Anti-inflammatory Activitiesmentioning

confidence: 99%

Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

et al. 2017

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Chronic diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best strategy for the prevention of these disorders. Health promoting benefits beyond their nutritional effects have been described for multiple dietary compounds. Among these compounds, the peptide lunasin is considered as one of the most promising. Naturally present in soybean, lunasin has been extensively studied in the last two decades because of its potential against chronic diseases such as cancer, cardiovascular and immunological disorders. The purpose of this article is to summarise the evidence on the presence of lunasin in soybean and derived foods, and its bioavailability once it is orally ingested. The protective and therapeutic effects of this peptide against cancer, oxidative stress, inflammation, and high cholesterol levels as well as the molecular mechanisms of action involved in these effects are also described in this review. © 2017 Society of Chemical Industry.

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Detection of lunasin in quinoa (Chenopodium quinoa Willd.) and the in vitro evaluation of its antioxidant and anti‐inflammatory activities

Abstract: Taken together, these findings indicate that lunasin presents in quinoa and is bioactive, which strengthens the recommendations for the development of quinoa-based functional foods. © 2017 Society of Chemical Industry.

Cited by 56 publications

References 25 publications

Bioactive Peptides

Bioactive Peptides

Food Proteins and Bioactive Peptides

Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

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