Detection of lung cancer using weighted digital analysis of breath biomarkers

Phillips, Michael; Altorki, Nasser K.; Austin, John; Cameron, Robert B.; Cataneo, Renee N.; Kloss, Robert A.; Maxfield, Roger A.; Munawar, Muhammad I.; Pass, Harvey I.; Rashid, Asif; Rom, William N.; Schmitt, Peter A.; Wai, James

doi:10.1016/j.cca.2008.02.021

Cited by 210 publications

(176 citation statements)

References 28 publications

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“…This is the second published report of the use of electronic nose breath profiling in MM and substantiates the promise of this technique as a simple, easy way for detecting malignancy which has previously been reported for lung cancer [15,[17][18][19]. A study by DRAGONIERI et al [28] published very recently, while our paper was under review, also reports high levels of discrimination between patients with MM and those with long-term asbestos exposure using an electronic nose system, with results almost identical to those of our study.…”

Section: Discussionmentioning

confidence: 70%

“…Breath volatile organic compound (VOC) profiling can distinguish lung cancer patients from healthy controls with a high degree of sensitivity and specificity [5]. More than 4,000 VOCs have been found in exhaled breath, generated mainly from endogenous biochemical pathways including those of lipid peroxidation [15][16][17][18][19][20][21]. Techniques used for VOC analysis range from gas chromatography-mass spectrometry and ion mobility spectroscopy to colorimetric and gas sensors.…”

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confidence: 99%

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A breath test for malignant mesothelioma using an electronic nose

et al. 2011

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Malignant mesothelioma (MM) is a rare tumour which is difficult to diagnose in its early stages. Earlier detection of MM could potentially improve survival. Exhaled breath sampling of volatile organic compounds (VOCs) using a carbon polymer array (CPA) electronic nose recognises specific breath profiles characteristic of different diseases, and can distinguish between patients with lung cancer and controls. With MM, the potential confounding effect of other asbestos-related diseases (ARDs) needs to be considered. We hypothesised that as CPA electronic nose would distinguish patients with MM, patients with benign ARDs, and controls with high sensitivity and specificity.20 MM, 18 ARD and 42 control subjects participated in a cross-sectional, case-control study. Breath samples were analysed using the Cyranose 320 (Smiths Detection, Pasadena, CA, USA), using canonical discriminant analysis and principal component reduction.10 MM subjects created the training set. Smell prints from 10 new MM patients were distinguished from control subjects with an accuracy of 95%. Patients with MM, ARDs and control subjects were correctly identified in 88% of cases.Exhaled breath VOC profiling can accurately distinguish between patients with MM, ARDs and controls using a CPA electronic nose. This could eventually translate into a screening tool for high-risk populations.

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Section: Discussionmentioning

confidence: 70%

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confidence: 99%

A breath test for malignant mesothelioma using an electronic nose

et al. 2011

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“…Over the last few years, urine and breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, due to painless, non-invasive sampling, and can be performed as often as needed [11]. Thousands of VOMs in trace amounts are present in human breath [12][13][14][15][16] and different studies have shown that the VOMs profile in patients with lung cancer can be discriminated from those of healthy subjects [12,17,18].…”

Section: Introductionmentioning

confidence: 99%

Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers—A powerful strategy for breast cancer diagnosis

Silva

Passos

Câmara

2012

Talanta

148

119

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a b s t r a c tA sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the urinary metabolomic profile of breast cancer patients and healthy individuals (control group) and to explore the VOMs as potential biomarkers in breast cancer diagnosis at early stage. Solid-phase microextraction (SPME) using CAR/PDMS sorbent combined with gas chromatography-mass spectrometry was applied to obtain metabolomic information patterns of 26 breast cancer patients and 21 healthy individuals (controls). A total of seventy-nine VOMs, belonging to distinct chemical classes, were detected and identified in control and breast cancer groups. Ketones and sulfur compounds were the chemical classes with highest contribution for both groups. Results showed that excretion values of 6 VOMs among the total of 79 detected were found to be statistically different (p < 0.05). A significant increase in the peak area of (−)-4-carene, 3-heptanone, 1,2,4-trimethylbenzene, 2-methoxythiophene and phenol, in VOMs of cancer patients relatively to controls was observed. Statiscally significant lower abundances of dimethyl disulfide were found in cancer patients. Bioanalytical data were submitted to multivariate statistics [principal component analysis (PCA)], in order to visualize clusters of cases and to detect the VOMs that are able to differentiate cancer patients from healthy individuals. Very good discrimination within breast cancer and control groups was achieved. Nevertheless, a deep study using a larger number of patients must be carried out to confirm the results.

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“…styrene), siloxanes, methoxy-phenyl oxime (a solid phase microextraction [SPME] fiber-derived compound), etc. [8][9][10][11][12][13][14][15][16][17][18] We have been involved in studies where a large number of gas sampling bags are used for sampling exhaled breath. Since flushing Tedlar bags with pure nitrogen or air is not feasible due to many bags employed, we have looked for an alternative material for sampling bags.…”

Section: Introductionmentioning

confidence: 99%

Dimerization Products of Chloroprene are Background Contaminants Emitted from ALTEF (Polyvinylidene Difhioride) Gas Sampling Bags

et al. 2017

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Gas sampling bags have been used for collecting air samples. Tedlar bags are most commonly used, but bleed background chemicals such as N,N-dimethylacetamide and phenol. It is often necessary to remove the contaminant by flushing the bags with pure nitrogen or air. In this study, we identified four chloroprene dimerization products as background contaminants emitted from ALTEF bags that are made of a proprietary polyvinylidene difluoride (PVDF). No monomer chloroprene was detected in the bags analyzed. All of the dimers gradually increased once bags were filled with nitrogen due to diffusion from the bag surface. Flushing the bags with nitrogen reduced their concentrations, but was not effective for removing the contaminants. When the bags that had been flushed with nitrogen 5 times were left for 24 h, they increased again, indicating that the dimers were constantly emitted from the ALTEF bag surface. To our knowledge, these compounds have never been demonstrated in ALTEF or other PVDF bags. Our finding indicates that ALTEF might be incorporated with Neoprene (chloroprene-based polymer) during its manufacturing process.

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Detection of lung cancer using weighted digital analysis of breath biomarkers

Cited by 210 publications

References 28 publications

A breath test for malignant mesothelioma using an electronic nose

A breath test for malignant mesothelioma using an electronic nose

Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers—A powerful strategy for breast cancer diagnosis

Dimerization Products of Chloroprene are Background Contaminants Emitted from ALTEF (Polyvinylidene Difhioride) Gas Sampling Bags

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