Detection of Lymph Node Micrometastases in Colorectal Cancer

Nordgård, Oddmund; Aloysius, Thomas A.; Todnem, K; Heikkilä, Reino; Øgreid, D

doi:10.1080/00365520310000591

Cited by 22 publications

(14 citation statements)

References 68 publications

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“…Many patients or parents may be reluctant to tell their physician about CAM use, possibly thinking that it is not relevant [18,27,36] but this aspect was not assessed in the current study. Furthermore, patients tend to believe that CAM therapies are safer and less toxic than conventional medication, which is not always true.…”

Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine use in adolescents with inflammatory bowel disease and juvenile idiopathic arthritis

Nousiainen

Merras‐Salmio

Aalto

et al. 2014

BMC Complement Altern Med

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BackgroundThe use of complementary alternative medicine (CAM) is potentially prevalent among paediatric patients with chronic diseases but with variable rates among different age groups, diseases and countries. There are no recent reports on CAM use among paediatric patients with inflammatory bowel disease (IBD) and juvenile idiopathic arthritis (JIA) in Europe. We hypothesized that CAM use associates with a more severe disease in paediatric IBD and JIA.MethodsA cross-sectional questionnaire study among adolescent outpatients with IBD and JIA addressing the frequency and type of CAM use during the past year. The patients were recruited at the Children’s Hospital, University of Helsinki, Finland.ResultsOf the 147 respondents, 97 had IBD (Crohn’s disease: n = 46; median age 15.5, disease duration 3.4 years) and 50 had JIA (median age 13.8, disease duration 6.9 years). During the past 12 months, 48% regularly used CAM while 81% reported occasional CAM use. Compared to patients with JIA, the use of CAM in IBD patients tended to be more frequent. The most commonly used CAM included probiotics, multivitamins, and mineral and trace element supplements. Self-imposed dietary restrictions were common, involving 27.6% of the non-CAM users but 64.8% of all CAM users. Disease activity was associated with CAM use in JIA but not in IBD.ConclusionsCAM use is frequent among adolescents with IBD and JIA and associates with self-imposed dietary restrictions. Reassuringly, adherence to disease modifying drugs is good in young CAM users. In JIA, patients with active disease used more frequently CAM than patients with inactive disease. As CAM use is frequent, physicians should familiarise themselves with the basic concepts of CAM. The potential pharmacological interaction or the toxicity of certain CAM products warrants awareness and hence physicians should actively ask their patients about CAM use.

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Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine use in adolescents with inflammatory bowel disease and juvenile idiopathic arthritis

Nousiainen

Merras‐Salmio

Aalto

et al. 2014

BMC Complement Altern Med

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“…3 It is difficult to prove that there is micrometastasis in the liver. In patients whose tumor cells are detected in circulating blood, metastasis in distant organs, including the liver, occurs at a high incidence, indicating that tumor cell detection in circulating blood can serve as an index of cancer recurrence.…”

Section: Discussionmentioning

confidence: 99%

Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR

et al. 2006

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“…Only few studies could show micrometastases detected by IHC in lymph nodes of UICC stage I and II patients to correlate with disease recurrence and survival (Noura et al, Lee et al, 2006;Messerini et al, 2006). These conflicting data may be due to the specificity and sensitivity of proteins used for detection as well as the variable thickness and number of tissue sections analysed (Nordgard et al, 2003). Therefore, we did not compare the results of rt-MSP with IHC studies.…”

Section: Discussionmentioning

confidence: 99%

CpG-island methylation of the ER promoter in colorectal cancer: analysis of micrometastases in lymph nodes from UICC stage I and II patients

et al. 2009

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Patients with UICC stage II colorectal cancer (CRC) have a risk of approximately 20% to develop disease recurrence after tumour resection. The presence and significance of micrometastases for locoregional recurrence in these patients lacking histopathological lymph node involvement on routine stained HE sections is undefined. Oestrogen receptor (ER) promoter methylation has earlier been identified in CRC. Therefore, we evaluated the methylation status of the ER promoter in lymph nodes from 49 patients with CRC UICC stage I and II as a molecular marker of micrometastases and predictor of local recurrence. DNA from 574 paraffinembedded lymph nodes was isolated and treated with bisulphite. For the detection of methylated ER promoter sequences, quantitative real-time methylation-specific PCR was used. Of the 49 patients tested, 15 (31%) had ER methylation-positive lymph nodes. Thirteen of those (86%) remained disease free and two (14%) developed local recurrence. In the resected lymph nodes of 34 of the 49 patients (69%), no ER promoter methylation could be detected and none of these patients experienced a local relapse. The methylation status of the ER promoter in lymph nodes of UICC stage I and II CRC patients may be a useful marker for the identification of patients at a high risk for local recurrence.

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Detection of Lymph Node Micrometastases in Colorectal Cancer

Abstract: Complementary medicine use is common in patients with IBD. Frequently cited reasons for the use of complementary therapies were safety of CAM; dissatisfaction with conventional therapies, including their side effects; and that CAM can be used in addition to conventional therapy.

Cited by 22 publications

References 68 publications

Complementary and alternative medicine use in adolescents with inflammatory bowel disease and juvenile idiopathic arthritis

Complementary and alternative medicine use in adolescents with inflammatory bowel disease and juvenile idiopathic arthritis

Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR

CpG-island methylation of the ER promoter in colorectal cancer: analysis of micrometastases in lymph nodes from UICC stage I and II patients

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