2011
DOI: 10.1007/s00417-011-1864-9
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Detection of macular and circumpapillary structural loss in normal hemifield areas of glaucomatous eyes with localized visual field defects using spectral-domain optical coherence tomography

Abstract: Perimetrically normal hemifields of glaucomatous eyes had significantly lower mGCC and cRNFL thicknesses than did the corresponding retinal regions of healthy eyes. SD-OCT may be a useful ancillary diagnostic tool for evaluation of early macular and circumpapillary structural changes in glaucomatous eyes with localized VF defects.

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Cited by 37 publications
(19 citation statements)
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“…24,27,28 Thus, GCC and RNFL parameters together are more sensitive than alone. [28][29][30] In our study, all GCC parameters except GCC thicknesses in inferior and inferonasal quadrants were found significantly thinner in exfoliative eyes than healthy subjects. But all GCC parameters were similar in exfoliative eyes and fellow eyes.…”
Section: Discussionsupporting
confidence: 54%
“…24,27,28 Thus, GCC and RNFL parameters together are more sensitive than alone. [28][29][30] In our study, all GCC parameters except GCC thicknesses in inferior and inferonasal quadrants were found significantly thinner in exfoliative eyes than healthy subjects. But all GCC parameters were similar in exfoliative eyes and fellow eyes.…”
Section: Discussionsupporting
confidence: 54%
“…9 Glaucoma often starts with a localized VF defect in one hemifield. 29, 27 The peripapillary VDs in retinal regions corresponding to perimetrically glaucomatous hemifields in myopic glaucomatous eyes with localized VF defects confined to one hemifield have been reported to be lower than those in the corresponding retinal regions in healthy eyes. 9 Our current study using OCTA-derived FAZ parameters supports the findings that the mean FAZ area in the hemimacular segments corresponding to VF defects is significantly larger than that in the hemimacular segments without VF defect in glaucomatous eyes with CVFDs.…”
Section: Discussionmentioning
confidence: 99%
“…28,29 Additionally, a significant correlation between macular inner retinal layer thickness and CVF defect (CVFD) has been reported in several studies. 26,[28][29][30][31] Recently, Rao et al 32 reported that macular vascular density (VD), evaluated by OCTA, was reduced in a glaucoma group compared with a healthy group, but diagnostic ability (area under the receiver operating characteristic curve of 0.63) was lower than that of peripapillary VD. To the best of our knowledge, little is known about the relationship between the status of FAZ microcirculation and CVFD in glaucoma patients, but a number of studies have shown reduced peripapillary or optic nerve head (ONH) VD measured with OCTA.…”
mentioning
confidence: 97%
“…14 Glaucoma patients often present with the loss of macular RGCs and nerve fiber layer thickness in the presence of CVF loss, even at early stages of the disease. 12,[17][18][19][20][21] Using OCTA, Rao et al 22 have demonstrated that macular vessel density (VD) in the parafoveal region (central 1-3 mm diameter zone) was reduced in patients with glaucoma compared with healthy eyes. Moreover, glaucomatous change in VD has been detected by serial OCTA measurements in the macular region in patients with primary open-angle glaucoma (POAG), suggesting the potential role of macular VD measurement to detect and monitor microvasculature changes in glaucoma.…”
mentioning
confidence: 99%