Detection of magnetic field effects by confocal microscopy

Déjean, Victoire; Konowalczyk, Marcin; Gravell, Jamie; Golesworthy, Matthew J.; Gunn, Catlin; Pompe, Nils; Elst, Olivia Foster Vander; Tan, Ke-Jie; Oxborrow, M.; Aarts, Dirk G. A. L.; Mackenzie, Stuart R.; Timmel, Christiane R.

doi:10.1039/d0sc01986k

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…An equivalent fitting procedure is described in detail in a recent study 18 . In contrast, the single exponential fitting corresponds to an entirely different procedure on an entirely different data set.…”

Section: Specific Criticisms Of Our Data Analysismentioning

confidence: 99%

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Radical pair based magnetic field effects in cells: the importance of photoexcitation conditions and single cell measurements

Woodward

Ikeya

2022

Preprint

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A recent publication on the bioRxiv preprint server aims to replicate our observation of magnetic field effects on the autofluorescence of HeLa cells, but is unable to reproduce the effects described in our original work. Here we examine this new study and demonstrate, based on a model of the reaction photocycle, why the differences in the measurement conditions used render the experiment unlikely to be able to observe the originally reported effect. In addition, we highlight substantial problems in the quality of the data in the replicate study and reiterate the advantages of the direct modulation, single cell measurement approach presented in the original work over a more standard statistical approach.

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Section: Specific Criticisms Of Our Data Analysismentioning

confidence: 99%

“…All the fluorescence decay curves were fitted with the following double exponential function for the baseline subtraction. An equivalent fitting procedure is described in detail in a recent study 18 . In contrast, the single exponential fitting corresponds to an entirely different procedure on an entirely different data set.…”

Section: Introductionmentioning

confidence: 99%