Detection of Male Breast Cancer With Tc-99m Methoxyisobutyl Isonitrile

Liu, Ming; Husain, Syed; Hameer, Hussein R.; Gona, Jayakumari

doi:10.1097/00003072-199911000-00013

Cited by 6 publications

(2 citation statements)

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“…three men were evaluated, one with a malignant tumor and two with benign tumors. case reports using 99m Tc-MDP (34), 99m Tc-sestamibi (35) and 99m Tc-tetrofosmin (36) have shown the diagnostic usefulness of scintigraphy for detecting breast cancer. We did not find any other studies that included breast tumors among men.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Moriguchi¹,

Luca²,

Griva³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. Scintimammography using 99m tc-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive. Because of the advantages of labeling with 99m Tc-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose. its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast. the objective of this study was to evaluate the accuracy of scintimammography for detecting breast cancer. One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated. three patients were male and 154 were female, aged between 14 and 81 years. all patients underwent scintimammography, and the nodule was subjected to cytological or histological study, i.e., the gold standard for diagnosing cancer. One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocystic condition (n=11/n=11), respectively. The mean size was 3.11 cm (7-10 cm) among the malignant nodules and 2.07 cm among the benign nodules (0.5-10 cm). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively. analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma. in this study, 99m tc-sestamibi scintimammography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusive.Introduction mammography is the safest method for breast cancer screening (1-3). It presents good sensitivity for detecting palpable and non-palpable lesions and low specificity for distinguishing between benign and malignant processes (4). hence, a biopsy is often required for diagnostic confirmation (5). It also presents limitations in relation to detection of lesions in dense breasts (6-8). mann et al demonstrated that false negative mammograms cause delays in undertaking biopsies among patients with cancer (9). the high rates of unnecessary biopsies in cases of benign lesions (10) have encouraged research on non-invasive techniques with greater precision. ultrasound, magnetic resonance imaging, positron emission tomography and scintigraphy are important aids for detecting cancer when mammography is indeterminate (11). high-risk patients (e.g., family antecedents, atypical proliferative lesions and previous cancer subjected to tumorectomy or radiotherapy) have benefited from combined use of these methods (11). Scintigraphy is a noninvasive imaging examination that uses small doses of radiation (12). it is painless, its cost and availability are reasonable and it enables functional or metabolic evaluation of various organs or structures. its advantage is unequivocal, especially when analysis using other methods is limited, and it stands out as a diagnostic eva...

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Section: Discussionmentioning

confidence: 99%

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Moriguchi¹,

Luca²,

Griva³

et al. 2010

Experimental and Therapeutic Medicine

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“…Tl‐201 scintigraphy (Ozdemir et al. , 1997), technetium and fluorodeoxyglucose positron emission tomography (Liu et al. , 1999; Eubank et al.…”

Section: Other Methodsmentioning

confidence: 99%

Review article Male breast cancer - an andrological disease: risk factors and diagnosis

Kŕause

2004

Andrologia

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Gynaecomastia, the enlargement of the male breast, is considered as an andrological disease. To date, a review on male breast cancer (MBC) has not been published in an andrological journal. The papers underlying this review were published from authors of different institutions: Clinical Genetics, Dermatology, Gynaecology, Internal Medicine, Oncology, Pathology, Psychiatry, Radiology and Surgery. MBC accounts for approximately 1% of breast cancer patients. A total of 182 men died of breast cancer in 1999, in Germany. In the US, 1500 new cases per year occur. MBC accounts for <5% of surgically removed breast lumps. Diseases with increased oestrogen action increase the risk of MBC. Mutations of distinct genes are estimated to account for up to roughly 10% of MBC. BRCA1 and BRCA2 gene mutations are responsible for approximately 80% of the families with hereditary breast cancer. The diagnosis of MBC is not possible without histological examination. Different diagnostic procedures such as clinical diagnosis, sonography, mammography, fine-needle biopsy and core needle facilitate the decision whether a biopsy is necessary.

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Breast Diseases in Males

Schuitevoerder

Vetto

2016

Management of Breast Diseases

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Detection of Male Breast Cancer With Tc-99m Methoxyisobutyl Isonitrile

Cited by 6 publications

References 0 publications

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Review article Male breast cancer - an andrological disease: risk factors and diagnosis

Breast Diseases in Males

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