Detection of malignant tumors of the breast and female reproductive organs during medical prophylactic examination of certain adult population groups

Старинский, В. В.; Александрова, Л. М.; Грецова, О. П.; Starinsky, V. V.; Каприн, А. Д.; Калинина, А. М.; Ipatov, P. V.; Бойцов, С. А.

doi:10.17116/profmed20161934-11

“…Discussion. The results of the study demonstrated that BrCa incidence in the cohort of female nuclear workers employed at the Mayak PA was associated with many nonradiation factors and the results were mostly in line with those obtained in other studies [2,5,6,8,12,[14][15][16][17][18][19][20][21][22]32].…”

supporting

confidence: 87%

“…BrCa is a multifactorial disease. There are several established factors that cause elevated risks of BrCa including age older than 40 years, early menarche (before 12 years of age), late menopause (at age 55 years and later), the first pregnancy terminated by abortion, infertility, age at first birth (30 years and later), breast feeding, reproductive losses, proliferative changes in breast tissues, BrCa in health history of immediate relatives, education, height, body mass index, smoking and some others [2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

mentioning

confidence: 99%

Risks of incidence of breast cancer in a cohort of females occupationally exposed to ionizing radiation

Rumyantseva¹,

Азизова²,

Банникова³

2021

Health Risk Analysis

0

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Breast cancer (BrCa) holds the first rank place in morbidity and mortality due to malignant neoplasms among Russian women. BrCa is a multifactorial disease and ionizing radiation is among factors that cause elevated risks of developing BrCa. Our research aim was to assess relative risk (RR) of incidence of BrCa among women who were occupationally exposed to chronic ionizing radiation taking into account radiation and non-radiation factors. RR of incidence of BrCa was analyzed in a cohort of women employed at a nuclear production enterprise, namely Mayak PA, in 1948–1982. 95 % of women started working at the enterprise at their reproductive age. All those women were chronically exposed to ionizing radiation at their workplaces. A mean cumulative breast absorbed dose of external gamma-ray exposure amounted to 0.45 (standard deviation was 0.68) Gy; an average cumulative muscle absorbed dose of internal alpha-particle exposure amounted to 0.003 (0.01) Gy. According to data taken from “Clinic” medical-dosimetric database, 165 BrCa cases were detected in 157 women of the analyzed cohort (8 women had BrCa in both breasts). Our analysis involved calculating RR of incidence of BrCa in relation to known non-radiation and radiation factors. Categorical data analysis was performed without age-related and calendar period-related stratification and with them. RR was analyzed based on Poisson regression with AMFIT module in EPICURE software package. Incidence of BrCa was revealed to be associated with attained age, age of menarche, age of menopause, number of abortions, age of concomitant diseases prior to cancer diagnosis, height, body mass index, age of hiring at the Mayak PA. There was no relationship between BrCa incidence and cumulative doses of occupational chronic external gamma-ray, internal alpha-particle and neutron exposure.

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“…Установленными (доказанными) факторами, повышаю-щими риск развития РМЖ, являются: возраст старше 40 лет, раннее менархе (до 12 лет), поздняя менопауза (после 55 лет), аборт при первой беременности, бесплодие, возраст первых родов (старше 30 лет), кормление грудью, репродуктивные потери, пролиферативные изменения в молочных железах (МЖ), наличие РМЖ у ближайших родственников, образование, рост, индекс массы тела, курение и др. [2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

unclassified

“…Результаты проведенного исследования показали, что заболеваемость РМЖ в когорте работниц предприятия атомной промышленности ПО «Маяк» зависит от большого количества нерадиационных факторов, что в основном хорошо согласуется с данными других исследований [2,5,6,8,12,[14][15][16][17][18][19][20][21][22]32]. Например, риск заболеваемости РМЖ ожидаемо воз-растал с увеличением достигнутого возраста [2,5,6], как и во многих других исследованиях.…”

unclassified

“…У женщин изучаемой когорты выявлен повышенный статистически значимый риск заболеваемости РМЖ при наличии сопутствующей патологии (миома матки, сахарный диабет, артериальная гипертензия, невротические расстройства) до установления диагноза РМЖ, что хорошо совпадает с результатами, полученными в других исследованиях [5,15,16,[18][19][20]. В то же время следует отметить, что при использовании модели, включающей поправки на достигнутый возраст и календарный период (модель 2), риск теряет свою статистическую значимость.…”

unclassified

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isks of incidence of breast cancer in a cohort of females occupationally exposed to ionizing radiation

Rumyantseva¹,

Азизова²,

Банникова³

2021

Health Risk Analysis

0

View full text Add to dashboard Cite

Breast cancer (BrCa) holds the first rank place in morbidity and mortality due to malignant neoplasms among Russian women. BrCa is a multifactorial disease and ionizing radiation is among factors that cause elevated risks of developing BrCa. Our research aim was to assess relative risk (RR) of incidence of BrCa among women who were occupationally exposed to chronic ionizing radiation taking into account radiation and non-radiation factors. RR of incidence of BrCa was analyzed in a cohort of women employed at a nuclear production enterprise, namely Mayak PA, in 1948–1982. 95 % of women started working at the enterprise at their reproductive age. All those women were chronically exposed to ionizing radiation at their workplaces. A mean cumulative breast absorbed dose of external gamma-ray exposure amounted to 0.45 (standard deviation was 0.68) Gy; an average cumulative muscle absorbed dose of internal alpha-particle exposure amounted to 0.003 (0.01) Gy. According to data taken from “Clinic” medical-dosimetric database, 165 BrCa cases were detected in 157 women of the analyzed cohort (8 women had BrCa in both breasts). Our analysis involved calculating RR of incidence of BrCa in relation to known non-radiation and radiation factors. Categorical data analysis was performed without age-related and calendar period-related stratification and with them. RR was analyzed based on Poisson regression with AMFIT module in EPICURE software package. Incidence of BrCa was revealed to be associated with attained age, age of menarche, age of menopause, number of abortions, age of concomitant diseases prior to cancer diagnosis, height, body mass index, age of hiring at the Mayak PA. There was no relationship between BrCa incidence and cumulative doses of occupational chronic external gamma-ray, internal alpha-particle and neutron exposure.

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Capabilities of Molecular Genetic Methods for Effective Hereditary Cancers Detection in Individuals with High Cancer Risk Factors

Semenova,

Byakhova,

Galkin

et al. 2023

City Healthcare

2

0

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Russia and other countries report an increase in the incidence of malignant neoplasms, and approximately 10 % of all oncological cases have hereditary background. Molecular genetic testing in patients with diagnosed malignant neoplasms and a suspected hereditary factor will help to select effective modern methods of treatment and prevention of the development of neoplasms of other localizations. According to the study, 12,6 % of patients had hereditary cancer syndrome, which allowed to administer molecular genetic tests to patients’ relatives. Consequently, it becomes possible to detect hereditary cancer risk factors, improve the efficiency of clinical examination, elaborate and implement programs for prevention and early detection of the disease.

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Detection of malignant tumors of the breast and female reproductive organs during medical prophylactic examination of certain adult population groups

Cited by 3 publications

References 7 publications

Risks of incidence of breast cancer in a cohort of females occupationally exposed to ionizing radiation

Risks of incidence of breast cancer in a cohort of females occupationally exposed to ionizing radiation

isks of incidence of breast cancer in a cohort of females occupationally exposed to ionizing radiation

Capabilities of Molecular Genetic Methods for Effective Hereditary Cancers Detection in Individuals with High Cancer Risk Factors

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