Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma

Katano, Harutaka; Ito, Hideki; Suzuki, Yoshio; Nakamura, T.; Sato, Yuko; Tsuji, Takahiro; Matsuo, Koma; Nakagawa, Hidemi; Sata, Tetsutaro

doi:10.1002/jmv.21608

Cited by 95 publications

(96 citation statements)

References 26 publications

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“…The MCPyV viral load on the skin surface varies from less than 1 copy per 1000 cells to 1000 copies per cell (9,26,30,(39)(40)(41). The mean DNA copy per cell in normal skin has been reported to be 0.02-0.07 (42).…”

Section: Detection Of the Viral Genomementioning

confidence: 99%

Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

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The Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associated with a relatively rare but aggressive neuroendocrine skin cancer, the Merkel cell carcinoma (MCC). MCC incidence is increasing due to the advancing age of the population, the increase in damaging sun exposure and in the number of immunocompromised individuals. MCPyV must be considered as the etiological agent of MCC and thus is the first example of a human oncogenic polyomavirus. MCPyV infection is common, and seroprevalence studies indicate that widespread exposure begins early in life. The majority of adults have anti-MCPyV antibodies and there is a growing body of evidence that healthy human skin harbors resident or transient MCPyV suggesting that MCPyV infection persists throughout life. However, the mode of transmission, the host cells, and the latency characteristics of this virus remain to be elucidated. In addition, it is still not clear whether MCPyV is associated with diseases or lesions other than Merkel cell carcinoma. The etiologic role of MCPyV in MCC opens up opportunities to improve the understanding of this cancer and to potentially improve its treatment.

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Section: Detection Of the Viral Genomementioning

confidence: 99%

Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

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“…However, unlike in mouse, a rare population of Merkel cells is found in human epidermis outside of TDs and hair follicles and is increased in number in response to sun exposure (Moll et al, 1990), suggesting that this unique Merkel cell population in human epidermis might be the origin of MCC. Although the etiology of MCC is unknown, several studies have implicated a role for Merkel cell polyomavirus (MCPyV) infection as a causal event (Feng et al, 2008;Katano et al, 2009;Andres et al, 2010). One intriguing possibility is that an abundance of CD200 provides immune privilege not only to normal TDPCs but also to MCPyV-transformed TDPCs, thereby contributing to MCC pathogenesis.…”

Section: Microarray Analysis Confirms a Distinct Transcriptome In Tdpcsmentioning

confidence: 99%

Identification of epidermal progenitors for the Merkel cell lineage

et al. 2010

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Epithelial stem cells in adult mammalian skin are known to maintain epidermal, follicular and sebaceous lineages during homeostasis. Recently, Merkel cell mechanoreceptors were identified as a fourth lineage derived from the proliferative layer of murine skin epithelium; however, the location of the stem or progenitor population for Merkel cells remains unknown. Here, we have identified a previously undescribed population of epidermal progenitors that reside in the touch domes of hairy skin, termed touch dome progenitor cells (TDPCs). TDPCs are epithelial keratinocytes and are distinguished by their unique co-expression of α6 integrin, Sca1 and CD200 surface proteins. TDPCs exhibit bipotent progenitor behavior as they give rise to both squamous and neuroendocrine epidermal lineages, whereas the remainder of the α6+ Sca1+ CD200– epidermis does not give rise to Merkel cells. Finally, TDPCs possess a unique transcript profile that appears to be enforced by the juxtaposition of TDPCs with Merkel cells within the touch dome niche.

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“…MCPyV has been detected in MCC patients and appears to play a key role in tumourigenesis; ~80% of MCCs harbour MCPyV (1). Using quantitative polymerase chain reaction (qPCR), MCPyV has been detected in malignant and benign tumours (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Moreover, certain investigators have reported that low viral loads of MCPyV have also been detected in normal human tissue samples, including skin, liver and respiratory secretions, suggesting that this virus is widespread in the human body (7,17).…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms

Tanio

Matsushita

Kuwamoto

et al. 2015

Molecular and Clinical Oncology

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Abstract. It was recently demonstrated that ~80% of Merkel cell carcinomas (MCCs) harbour a novel polyomavirus, Merkel cell polyomavirus (MCPyV). MCPyV has been detected in various human tissue samples. However, previous studies on the prevalence of MCPyV in oral tumours or tumour-like lesions are incomplete. To address this issue, we measured MCPyV DNA quantity using quantitative polymerase chain reaction (qPCR) in 327 oral tumours or tumour-like lesions and 54 jaw tumours or cyst lesions from 381 immunocompetent patients, as well as in 4 oral lesions from 4 immunosuppressed patients. qPCR revealed a low MCPyV prevalence (25/381, 6.6%) with low viral loads (0.00024-0.026 copies/cell) in oral and maxillofacial tumours and tumour-like lesions from immunocompetent patients. The prevalence was 7/176 (4.0%) in invasive squamous cell carcinomas (SCCs) [2/60 (3.33%) SCCs of the tongue, 4/52 (7.7%) SCCs of the gingiva and 1/19 (5.3%) SCCs of the floor of the mouth], 1/10 (10%) in dysplasias, 1/5 (20%) in adenocarcinomas, 2/13 (15.4%) in adenoid cystic carcinomas,

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Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma

Cited by 95 publications

References 26 publications

Human Merkel cell polyomavirus: virological background and clinical implications

Human Merkel cell polyomavirus: virological background and clinical implications

Identification of epidermal progenitors for the Merkel cell lineage

Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms

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