Detection of Metallo-beta-lactamase Producing Pseudomonas aeruginosa in an Abidjan Hospital, Côte d’Ivoire

Gba, Karine; Guessennd, Nathalie; Makaya, Nicole Prisca Nieko Dangui; Tahou, E; Konan, Fernique; Toty, A; Nguetta, Simon-Pierre A.

doi:10.9734/jamb/2018/38792

Cited by 2 publications

(1 citation statement)

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“…The emergence and spread of clinical carbapenemase-producing P. aeruginosa (MBLs) has become a serious concern and health care problem around the world [23]. The MBL prevalence is 13.82% which is similar to that in Côte d'Ivoire (12.5%) [24], but lower than that in Egypt 68.7% [25]. The presence of VIM-type enzymes was responsible of carbapenem resistance in our MBL-producing isolates.…”

Section: Discussionmentioning

confidence: 61%

Occurrence of VIM-4 metallo-β-lactamase-producing Pseudomonas aeruginosa in an Algerian hospital

Merradi

Kassah-Laouar

Ayachi

et al. 2019

J Infect Dev Ctries

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Introduction: Pseudomonas aeruginosa is one of the most common nosocomial pathogens, known with a wide resistance to antimicrobials. Carbapenemases producing Pseudomonas aeruginosa is a growing global public health concern as this pathogen is easily transmissible among patients. Metallo-Beta-lactamases is the most important class of these carbapenemases with their broad-spectrum resistance profile. This study was conducted to investigate the prevalence of MBL-producing P. aeruginosa collected in an Algerian hospital. Methodology: All Metallo-β-lactamase (MBL)-producing P. aeruginosa isolates recovered from patients during a 2 years period (2015-2016) were studied using a combination of phenotypic and molecular typing methods (susceptibility testing, molecular characterization of carbapenemase-encoding genes, multi-locus sequence typing and pulsed-field gel electrophoresis). Results: A total of twenty-six MBL producing P. aeruginosa of 188 isolates were investigated. The burns unit ranked in the first position of the majority of identified cases with 73.07%. About 73.07% of total MBL isolates were mainly isolated from pus samples. The studied isolates were subjected to the molecular typing, in which 4 different Dra1-PFGE patterns and 3 sequences type were assigned (ST244, ST381, and ST1076), and all isolates were revealed positive for VIM-4. Conclusions: We report the third description of blaVIM-4 in Algeria indicating the emergence and spread of carbapenemase-encoding genes among P. aeruginosa in the hospital environment.

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Section: Discussionmentioning

confidence: 61%