Detection of multiple gland primary hyperparathyroidism in the era of minimally invasive parathyroidectomy

Diagnostic Accuracy of 4D-CT for Parathyroid Adenomas and Hyperplasia

“…These results compare favorably to those reported for sonography and sestamibi techniques. A review by Sugg et al, 12 including 23 patients with multigland disease, found that the combination of sonography and sestamibi imaging correctly predicted multigland disease in 30% of patients, incorrectly called single-gland disease in 30%, did not identify abnormal parathyroid glands in 30%, and yielded discordant results in 10%. In our cohort, 2 of the 3 false-negatives for parathyroid lesion detection were patients with multigland disease.…”

The Accuracy of Ultrasound in the Pre-Operative Localisation of Parathyroid Lesions in Primary Hyperparathyroidism: A Review of the Literature

“…In clinical practice each test is often treated as complementary to the other, and is not interpreted in isolation with the alternate test. The combination of the findings from both US and NM has been proven to increase the overall sensitivity in identifying and localizing parathyroid lesions (Bhansali et al 2006;Lo et al 2007;Sugg et al 2004). …”

“…Prasannan et al (2007) who provided no information on the execution of the Tc 99m sestamibi scan, and Shaheen et al (2008) who provided no information on the experience or credentials of the operator(s). Whilst most studies used pre-operative or post-operative hormone assays, only three studies (Bhansali et al 2006;Prasannan et al 2007;Sugg et al 2004) provided clear cut-off values for normal or abnormal assays.…”

“…Six studies compared US and NM to surgical findings (Bhansali et al 2006;Carlier et al 2008, Lo et al 2007Prasannan et al 2007;Shaheen et al 2008;Sugg et al 2004). Mihai et al (2006) differed by not directly comparing US to surgical findings, instead comparing it to NM only, then comparing NM to surgical findings.…”

“…US was performed by experienced radiologists in two studies (Carlier et al 200;Lo et al 2007), experienced sonographers in two studies (Bhansali et al 2006;Sugg et al 2004), a parathyroid surgeon in one study (Prasannan et al 2007) and the operator was not specified by Mihai et al (2006) or Shaheen et al (2008). Two studies (Lo et al 2007;Shaheen et al 2008) indicated that multiple operators were involved in performing the ultrasound examinations in their studies.…”