Detection of Myocardial Injury Using miRNAs Expression as Genetic Biomarkers in Acute Cardiac Care

Rogobete, Alexandru Florin; Bedreag, Ovidiu Horea; Popovici, Sonia Elena; Sas, Adriana; Stan, Adrian Tudor; Stoicescu, Emil Robert; Săndesc, Dorel

doi:10.1515/jce-2016-0025

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…The cardiac function was examined using echocardiography, which showed normal parameters in all cases [ 21 , 35 ]. Taking into consideration that all patients are clinically vulnerable and the long-term effects of the SARS-CoV-2 infection are yet to be discover, it would be necessary to have an additional investigating tool, such as the genetic expression of miRNAs, with a higher selectivity and specificity rate than the usual biomarkers [ 36 ]. For a better analysis of myocardial dysfunctions, echocardiogram and echocardiography have proven effective, as they are used in the ‘SAFE protocol’ for critically ill neonates [ 5 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Is Lung Ultrasound Helpful in COVID-19 Neonates?—A Systematic Review

et al. 2021

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Background: The SARS-CoV-2 infection has occurred in neonates, but it is a fact that radiation exposure is not recommended given their age. The aim of this review is to assess the evidence on the utility of lung ultrasound (LUS) in neonates diagnosed with COVID-19. Methods: A systematic literature review was performed so as to find a number of published studies assessing the benefits of lung ultrasound for newborns diagnosed with COVID and, in the end, to make a comparison between LUS and the other two more conventional procedures of chest X-rays or CT exam. The key terms used in the search of several databases were: “lung ultrasound”, “sonography”, “newborn”, “neonate”, and “COVID-19′. Results: In total, 447 studies were eligible for this review, and after removing the duplicates, 123 studies referring to LU were further examined, but only 7 included cases of neonates. These studies were considered for the present research paper. Conclusions: As a non-invasive, easy-to-use, and reliable method for lung lesion detection in neonates with COVID-19, lung ultrasound can be used as a useful diagnosis tool for the evaluation of COVID-19-associated lung lesions. The benefits of this method in this pandemic period are likely to arouse interest in opening new research horizons, with immediate practical applicability.

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Section: Discussionmentioning

confidence: 99%

Is Lung Ultrasound Helpful in COVID-19 Neonates?—A Systematic Review

et al. 2021

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“…This reaction takes place only if it is catalyzed by the DiGeorge Syndrome Critical Region 8 (DGCR8). [43][44][45][46] The transporting protein, Exportin 5, will then act on the pre-miRNAs, which will transfer the epigenetic complex from the nucleus to the cell cytoplasm. [47][48][49] Once the signal that the complex has reached the cytoplasm is received, RNA polymerase III (Dicer) and trans-activator RNA binding protein (TRBP) attack it and lead to the formation of mature miRNAs.…”

Section: The Most Common Molecular Mechanisms Involved In Cvdsmentioning

confidence: 99%

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

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Worldwide, cardiovascular diseases (CVDs) represent one of the main causes of morbidity and mortality, and acute coronary syndromes are responsible for a large number of sudden cardiac deaths. One of the main challenges that still exist in this area is represented by the early detection and targeted monitoring of the pathophysiology involved in CVDs. During the last couple of years, researchers have highlighted the importance of molecular and epigenetic mechanisms involved in the initiation and augmentation of CVDs, culminating in their most severe form represented by acute myocardial infarction. One of the most studied molecular factors involved in this type of pathology is represented by nuclear transcription factor kappa B (NF-κB), as well as the involvement of microRNAs (miRNAs). It has been suggested that miRNAs can also be involved in the complex process of atheromatous plaque vulnerabilization that leads to an acute cardiac event. In this review paper, we describe the most important molecular mechanisms involved in the pathogenesis of CVDs and atheromatous plaque progression and vulnerabilization, which include molecular mechanisms dependent on NF-κB. For this paper, we used international databases (PubMed and Scopus). The keywords used for the search were “miRNAs biomarkers”, “miRNAs in cardiovascular disease”, “NF-κB in cardiovascular disease”, “molecular mechanism in cardiovascular disease”, and “myocardial NF-κB mechanisms”. Numerous molecular reactions that have NF-κB as a trigger are involved in the pathogenesis of CVDs. Moreover, miRNAs play an important role in initiating and aggravating certain segments of CVDs. Therefore, miRNAs can be used as biomarkers for early evaluation of CVDs. Furthermore, in the future, miRNAs could be used as a targeted molecular therapy in order to block certain mechanisms responsible for inducing CVDs and leading to acute cardiovascular events.

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“…Together with the augmentation of the redox status, a series of biological cellular systems are affected, such as DNA and protein destruction or the lipid status, through their destruction and the implicit production of new free radical species. Regarding the evaluation and monitoring of OS using specific serum biomarkers, the most representative to date are malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) for lipid peroxidation, while for protein peroxidation, the most important ones are carbonyl groups and nitrotyrosine [ 23 – 26 ]. Other biomarkers that could offer answers in regard to pro-oxidative and proinflammatory status are specific cytokines such as interleukin 1 (IL-1), interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor alpha (TNF-α).…”

Section: Reviewmentioning

confidence: 99%

The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review

et al. 2017

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The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related to the association of the aforementioned pathologies. The nutrition of the critically ill polytrauma patient is a distinct challenge because of the rapid changes in terms of energetic needs associated with hypermetabolism, sepsis, SIRS, and OS. Moreover, it has been proven that inadequate nutrition can prolong the time spent on a mechanical ventilator and the length of stay in an intensive care unit (ICU). A series of mathematical equations can predict the energy expenditure (EE), but they have disadvantages, such as the fact that they cannot predict the EE accurately in the case of patients with hypermetabolism. Indirect calorimetry (IC) is another method used for evaluating and monitoring the energy status of critically ill patients. In this update paper, we present a series of pathophysiological aspects associated with the metabolic disaster affecting the critically ill polytrauma patient. Furthermore, we present different non-invasive monitoring methods that could help the intensive care physician in the adequate management of this type of patient.

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Detection of Myocardial Injury Using miRNAs Expression as Genetic Biomarkers in Acute Cardiac Care

Cited by 5 publications

References 34 publications

Is Lung Ultrasound Helpful in COVID-19 Neonates?—A Systematic Review

Is Lung Ultrasound Helpful in COVID-19 Neonates?—A Systematic Review

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review

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