Detection of new psychoactive substance use among emergency room patients: Results from the Swedish STRIDA project

Helander, Anders; Bäckberg, Matilda; Hultén, Peter; Al-Saffar, Yasir; Beck, Olof

doi:10.1016/j.forsciint.2014.02.022

Cited by 114 publications

(103 citation statements)

References 22 publications

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“…However, many synthetic tryptamine derivatives have been synthesized and are recreationally used as novel psychoactive substances (Araujo et al, 2015;EMCDDA, 2014;Helander et al, 2014;Kamour et al, 2014;Shulgin and Shulgin, 1997;Tittarelli et al, 2015;Winstock et al, 2014). Tryptamines share their core structure with the neurotransmitter serotonin (5-hydroxytryptamine ).…”

Section: Introductionmentioning

confidence: 99%

“…Different N-substitutions also influenced in vivo potency (Nichols et al, 2015;Repke et al, 1985). The pharmacological profiles of many tryptamines have been studied previously at selected targets (Blough et al, 2014;Gatch et al, 2011;McKenna et al, 1990;Nichols et al, 2015;Repke et al, 1985;Shulgin and Carter, 1980), and new and pharmacologically unknown tryptamine derivatives are constantly emerging on the illicit drug market (Araujo et al, 2015;Corkery et al, 2012;EMCDDA, 2014;Greene, 2013;Helander et al, 2014;Tittarelli et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

Rickli

Moning

Hoener

et al. 2016

European Neuropsychopharmacology

271

266

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

Rickli

Moning

Hoener

et al. 2016

European Neuropsychopharmacology

271

266

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“…Para-(4)-phenyl-substituted amphetamines, which have emerged in recent years, with novel psychoactive substances and forensic cases (Helander et al, 2014;Johansen and Hansen, 2012;Rohrich et al, 2012;Rust et al, 2012). Users report that the subjective effects of 4-methlylmethcathinone (Carhart-Harris et al, 2011) and 4-fluoroamphetamine (Erowid, 2014) are comparable to those of MDMA.…”

Section: Introductionmentioning

confidence: 99%

“…All of these cathinones are characterized by a pyrrolidine ring structure, making them different structurally and possibly also pharmacologically from other synthetic cathinones Simmler et al, 2013). Among the pyrovalerone cathinones, MDPV is currently the most widely detected and used, both in the EU (European Monitoring Center for Drugs and Drug Addiction, 2014b;Helander et al, 2014;Zuba and Byrska, 2013) and US (Leffler et al, 2014;Marinetti and Antonides, 2013;Spiller et al, 2011). In fact, MDPV has become the most frequently detected and used of all cathinones ("bath salts") in some EU countries (Helander et al, 2014;Zuba and Byrska, 2013) and the US (Leffler et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Among the pyrovalerone cathinones, MDPV is currently the most widely detected and used, both in the EU (European Monitoring Center for Drugs and Drug Addiction, 2014b;Helander et al, 2014;Zuba and Byrska, 2013) and US (Leffler et al, 2014;Marinetti and Antonides, 2013;Spiller et al, 2011). In fact, MDPV has become the most frequently detected and used of all cathinones ("bath salts") in some EU countries (Helander et al, 2014;Zuba and Byrska, 2013) and the US (Leffler et al, 2014). More recently, a second generation of MDPV-like cathinones, including α-PVP, MDPPP, and MDPBP, has been detected and/or used in several EU countries (Eiden et al, 2013;Helander et al, 2014;Westphal et al, 2011;Zuba and Byrska, 2013) and the US (Elliott and Evans, 2014;Smollin et al, 2011;Thornton et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

Rickli

Hoener

Liechti

2015

European Neuropsychopharmacology

169

188

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The pharmacology of novel psychoactive substances is mostly unknown. We evaluated the transporter and receptor interaction profiles of a series of para-(4)-substituted amphetamines and pyrovalerone cathinones. We tested the potency of these compounds to inhibit the norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters (NET, DAT, and SERT, respectively) using human embryonic kidney 293 cells that express the respective human transporters. We also tested the substance-induced efflux of NE, DA, and 5-HT from monoamine-loaded cells, binding affinities to monoamine receptors, and 5-HT 2B receptor activation.Para- (4)

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Simultaneous determination of 75 abuse drugs including amphetamines, benzodiazepines, cocaine, opioids, piperazines, zolpidem and metabolites in human hair samples using liquid chromatography–tandem mass spectrometry

Shin

Kong

Cheong

et al. 2019

Biomedical Chromatography

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A liquid chromatography–tandem mass spectrometric method for the simultaneous determination of 75 abuse drugs and metabolites, including 19 benzodiazepines, 19 amphetamines, two opiates, eight opioids, cocaine, lysergic acid diethylamide, zolpidem, three piperazines and 21 metabolites in human hair samples, was developed and validated. Ten‐milligram hair samples were decontaminated, pulverized using a ball mill, extracted with 1 mL of methanol spiked with 28 deuterated internal standards in an ultrasonic bath for 60 min at 50°C, and purified with Q‐sep dispersive solid‐phase extraction tubes. The purified extracts were evaporated to dryness and the residue was dissolved in 0.1 mL of 10% methanol. The 75 analytes were analyzed on an Acquity HSS T3 column using gradient elution of methanol and 0.1% formic acid and quantified in multiple reaction monitoring mode with positive electrospray ionization. Calibration curves were linear (r ≥ 0.9951) from the lower limit of quantitation (2–200 pg/mg depending on the drug) to 2000 pg/mg. The coefficients of variation and accuracy for intra‐ and inter‐assay analysis at three QC levels were 4.3–12.9% and 89.2–109.1%, respectively. The overall mean recovery ranged from 87.1 to 105.3%. This method was successfully applied to the analysis of 11 forensic hair samples obtained from drug abusers.

show abstract

Detection of new psychoactive substance use among emergency room patients: Results from the Swedish STRIDA project

Cited by 114 publications

References 22 publications

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

Simultaneous determination of 75 abuse drugs including amphetamines, benzodiazepines, cocaine, opioids, piperazines, zolpidem and metabolites in human hair samples using liquid chromatography–tandem mass spectrometry

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