We use the WISE-2MASS infrared galaxy catalog matched with Pan-STARRS1 (PS1) galaxies to search for a supervoid in the direction of the Cosmic Microwave Background Cold Spot. Our imaging catalog has median redshift z ≃ 0.14, and we obtain photometric redshifts from PS1 optical colours to create a tomographic map of the galaxy distribution. The radial profile centred on the Cold Spot shows a large low density region, extending over 10's of degrees. Motivated by previous Cosmic Microwave Background results, we test for underdensities within two angular radii, 5 • , and 15 • . The counts in photometric redshift bins show significantly low densities at high detection significance, ∼ > 5σ and ∼ > 6σ, respectively, for the two fiducial radii. The line-of-sight position of the deepest region of the void is z ≃ 0.15 − 0.25. Our data, combined with an earlier measurement by Granett et al. (2010), are consistent with a large R void = (220 ± 50)h −1 Mpc supervoid with δ m ≃ −0.14 ± 0.04 centered at z = 0.22 ± 0.03. Such a supervoid, constituting at least a ≃ 3.3σ fluctuation in a Gaussian distribution of the ΛCDM model, is a plausible cause for the Cold Spot.