Detection of Nonexudative Choroidal Neovascularization in Age-Related Macular Degeneration With Optical Coherence Tomography Angiography

Palejwala, Neal V.; Jia, Yali; Gao, Simon S.; Liu, Liang; Flaxel, Christina J.; Hwang, Thomas S.; Lauer, Andreas K.; Wilson, David J.; Huang, David; Bailey, Steven T.

doi:10.1097/iae.0000000000000867

Cited by 148 publications

(107 citation statements)

References 23 publications

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“…The PR algorithm, together with the Saliency algorithm, also more cleanly completely separated CNV flow signal from projected clutter. This ability may improve the early detection of CNV [37] and the management anti-VEGF therapy in neovascular AMD [38], another leading cause of blindness [19].…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Projection-resolved optical coherence tomographic angiography

Zhang

Hwang

Campbell

et al. 2016

Biomed. Opt. Express

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Shadowgraphic projection artifacts from superficial vasculature interfere with the visualization of deeper vascular networks in optical coherence tomography angiography (OCT-A). We developed a novel algorithm to remove this artifact by resolving the ambiguity between in situ and projected flow signals. The algorithm identifies voxels with in situ flow as those where intensity-normalized decorrelation values are higher than all shallower voxels in the same axial scan line. This "projection-resolved" (PR) algorithm effectively suppressed the projection artifact on both en face and cross-sectional angiograms and enhanced depth resolution of vascular networks. In the human macula, the enhanced angiograms show three distinct vascular plexuses in the inner retina and no vessels in the outer retina. We demonstrate that PR OCT-A cleanly removes flow projection from the normally avascular outer retinal slab while preserving the density and continuity of the intermediate and deep retinal capillary plexuses.

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Section: Conclusion and Discussionmentioning

confidence: 99%

Projection-resolved optical coherence tomographic angiography

Zhang

Hwang

Campbell

et al. 2016

Biomed. Opt. Express

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300

265

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“…OCTA has been demonstrated to visualize areas of retinal non-perfusion [88,89] and the foveal avascular zone (FAZ) of the retinal capillaries [90] , which are essential to describe the DR progression [91] . OCTA has also been reported to be sensitive in detecting Type I [92] , Type II [93] , and Type III [94] choroidal neovascularization (CNV) in AMD patients. Furthermore, OCTA has been suggested to visualize alterations in the choriocapillaris of patients from dry AMD [95,96] .…”

Section: Optical Coherence Tomography Angiography (Octa)mentioning

confidence: 99%

New Frontiers in Retinal Imaging

Liu

Paulus

2016

International Journal of Ophthalmic Research

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Ophthalmology is one of the most technology-driven medical specialties with numerous recent advances due to improvements in imaging technology. Advances in retinal imaging have allowed for better understanding of the eye in health and disease, retinal pathophysiology, documenting of disease progression,and assessing therapeutic response. During the last 50 years, both the hardware such as lasers in addition to software image analysis have significantly evolved. These improvements have included facilitating the progress of the ocular examination, reducing the discomfort of patients, and obtaining high quality non-invasive images. This article will review the classic retinal imaging modalities, state-of-the-art retinal imaging technologies, and an introduction of emerging imaging technologies.

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“…Palejwala és mtsai [21] nagy kockázatú, nem exsudativ AMD-esetek vizsgálatakor 6%-ban találtak olyan CNV-t, amely FA-n nem mutatott szivárgást, azonban mégis jelen volt, de nem volt aktív. Ez arra mutat rá, hogy bizonyos esetekben az OCT-A hamarabb kimutathatja az érújdonképződést, mint a hagyományos angiográfia.…”

Section: Eredeti Közleményunclassified

Szemfenéki érfestés festék nélkül: Az optikai koherencia tomográfia alapú angiográfia exsudativ típusú időskori maculadegenerációban

et al. 2016

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Bevezetés: Az időskori maculadegeneráció exsudativ formájának elfogadott és hatékony kezelése a vascularis endothelialis növekedési faktort gátló kezelés. Célkitűzés: Annak morfológiai leírása, milyen érrendszer észlelhető a macula területében több éve tartó tartós kezelés után. Módszer: A vizsgálatba 48 beteget (34 nő, 14 férfi, életkor 74,4 ± 8,0 év) vontak be, akiknél legalább 24 hónappal korábban kezdték meg a vascularis endothelialis növekedési faktort gát-ló kezelést (ranibizumab, aflibercept). A kezelt 56 szemnél a követési idő (53,8 ± 31,0 hónap) alatt összesen 7,6 ± 4,9 injekciót alkalmaztak. AngioVue (Optovue Inc., Fremont, CA, Amerikai Egyesült Államok) készülékkel optikai koherencia tomográfia-angiográfia vizsgálatot végeztek. Eredmények: A felszínes retinaerek károsodását 5/56 esetben, a mélyebb retinakeringés kiesését 9/56 esetben tapasztalták. A choriocapillaris károsodására, az érújdonképződést követő eltérésekre négyféle kép volt a jellemző: 1. pigmenthám-és choriocapillaris-atrophia, 2. submacularis heg, 3. aktív neovascularisatio, 4. intraretinalis ciszták. Következtetés: Az optikai koherencia tomográfia-angiográfia noninvazív módszer, amelynek segítségével a maculadegeneráció jól nyomon követhető. Orv. Hetil., 2016, 157(42), 1683-1690. Kulcsszavak: maculadegeneráció, optikai koherencia tomográfia, angiográfia Angiography of the ocular fundus without dye: Optical coherence tomography based angiography in exsudative age-related macular degenerationIntroduction: Vascular endothelial growth factor antibody therapy is an established treatment of exsudative age-related macular degeneration. Aim: The morphologic characterisation of the macular microvasculature after longstanding treatment. Method: Forty-eight patients (34 women and 14 men; age, 74.4 ± 8.0 years) were enrolled in the study. During follow-up time (53.8 ± 31.0 months), 7.6 ± 4.9 injections were administered in 56 eyes. Optical coherence tomography angiographic examination was performed with AngioVue (Optovue Inc. Fremont, CA, USA). Results: Distortion of the superficial retinal plexus and foveal avascular zone enlargement were noted in 5/56 eyes, deep retinal plexus defect was detected in 9/56 cases. Destruction of the choriocapillaries and the former neovascularisation could be found in 4 different patterns: 1. pigment epithelium and choriocapillary atrophy, 2. submacular scar, 3. active leaking choroidal neovascularisation, 4. intraretinal cysts. Conclusion: Optical coherence tomography angiography is a novel non-invasive method, which enables the follow up of macular degeneration.

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Detection of Nonexudative Choroidal Neovascularization in Age-Related Macular Degeneration With Optical Coherence Tomography Angiography

Cited by 148 publications

References 23 publications

Projection-resolved optical coherence tomographic angiography

Projection-resolved optical coherence tomographic angiography

New Frontiers in Retinal Imaging

Szemfenéki érfestés festék nélkül: Az optikai koherencia tomográfia alapú angiográfia exsudativ típusú időskori maculadegenerációban

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