Detection of obstructive uropathy and assessment of differential renal function using two functional magnetic resonance urography tools

Genseke, Philipp; Rogasch, J; Steffen, Ingo G.; Neumann, Grit; Apostolova, Ivayla; Ruf, Juri; Rißmann, Anke; Wiemann, Dagobert; Liehr, Uwe-Bernd; Schostak, Martin; Amthauer, Holger; Furth, Christian

doi:10.3413/nukmed-0833-16-06

Cited by 7 publications

(11 citation statements)

References 26 publications

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“…The use of functional MR urography in determining kidney volume is already accepted as the gold standard in clinical practice regarding complex anatomy architecture cases such as autosomal dominant polycystic kidney disease (31,32). Contrary to recently reported results (21), we found that the absolute difference in volumetric SRF between functional MR urography and DRS did not exceed the accepted tolerance threshold of 5%. The major difference between the protocol adopted in this study and the one from other groups (21,33) is the time and modality of furosemide and Gadolinium-based Contrast Agents administration: while we use the F-0 technique and a micro-bolus of Gadoliniumbased Contrast Agents (7) injection at higher flow rate, other groups adopt the F-15 method (34) with slow Gadoliniumbased Contrast Agents injection.…”

Section: Discussioncontrasting

confidence: 99%

“…Contrary to recently reported results (21), we found that the absolute difference in volumetric SRF between functional MR urography and DRS did not exceed the accepted tolerance threshold of 5%. The major difference between the protocol adopted in this study and the one from other groups (21,33) is the time and modality of furosemide and Gadolinium-based Contrast Agents administration: while we use the F-0 technique and a micro-bolus of Gadoliniumbased Contrast Agents (7) injection at higher flow rate, other groups adopt the F-15 method (34) with slow Gadoliniumbased Contrast Agents injection. We suppose that the use of ImageJ MRU plug-in protocol associated with the original method of F-0 technique has better correlation with volumetric SRF calculated by DRS and this may explain differences from previous reported data.…”

Section: Discussioncontrasting

confidence: 99%

“…We underline that results on the evaluation of SRF may be correlated to normal renal function of all cases. The comparison between functional MR urography and DRS in measuring obstruction can be evaluated by functional MR urography and DRS renal transit time (21) or by timeintensity-drainage curve morphology according to O'Reilly's classification (5,35). In order to simplify the comparison between the two imaging techniques, we introduced a common drainage curve classification system based on normal, borderline and accumulation curves (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…Comparative studies on volumetric SRF evaluation by DRS and functional MR urography have shown a good correlation between the two techniques, where functional MR urography offers the advantage of calculating the volume of enhanced renal parenchyma (16)(17)(18)(19)(20)(21). Although these provide evidence for a comprehensive multicenter comparative study on different CAKUT phenotypes which calculate the volumetric SRF using the Area Under the Curve, the Rutland-Patlak method and the volume proportion expressed as a percentage together with the comparative evaluation of drainage curves is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Damasio

Bodria

Dolores³

et al. 2020

Front. Pediatr.

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Background: Obstructive congenital anomalies of the kidney and urinary tract have a high risk of kidney failure if not surgically corrected. Dynamic renal scintigraphy is the gold standard technique to evaluate drainage curves and split renal function (SRF).Objectives: To compare functional magnetic resonance (MR) urography with dynamic renal scintigraphy in measuring volumetric SRF and in the classification of drainage curves in patients with congenital anomalies of the kidney and urinary tract. Materials and Methods:We retrospectively collected patients with hydroureteronephrosis or pelvicalyceal dilatation at renal ultrasound, who underwent both functional MR urography and dynamic renal scintigraphy (DRS) within 6 months. DRS studies were evaluated by a single nuclear medicine physician with a double reading. Functional MR urography renograms were blind evaluated twice by two radiologists. The functional MR urographyintra-and inter-reading agreements as well as the agreement between the two imaging techniques were calculated. SRF was evaluated by Area Under the Curve and Rutland-Patlak methods. Drainage curves were classified as normal, borderline or accumulation patterns by both the techniques.Results: Fifty-two children were studied, 14 with bilateral involvement. A total of 104 kidney-urinary tracts were considered: 38 normal and 66 dilated. Considering Area Under the Curve and Rutland-Patlak for SRF, the intra-and inter-reader agreements of functional MR urography had excellent and good results, respectively, and the two techniques demonstrated a good concordance (r2: 67% for Area Under the Curve and 72% for Rutland-Patlak). Considering drainage curves, the inter-readers agreement Damasio et al. fMRU vs DRS in Children for functional MR urography and the concordance between the two techniques were moderate (Cohen's k, respectively, 55.7 and 56.3%).Conclusions: According to our results, there are no significant differences between functional MR urography and DRS in measuring volumetric SRF and in the classification of drainage curves in patients with congenital anomalies of the kidney and urinary tract.Keywords: obstructive uropathy, dynamic renal scintigraphy, functional magnetic resonance urography, congenital anomalies of the kidney and urinary tract, CAKUT

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Damasio

Bodria

Dolores³

et al. 2020

Front. Pediatr.

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“…Percutaneous nephrostomy and internal stent are equally effec-tive. The inner stent is less effective in the ureteral obstruction, with a high chance of failure, especially in malignant and metastatic disease, chemotherapy, radiotherapy, and kidney failure; therefore, nephrostomy is a more appropriate option (5,6). In cases with coagulation disorder, ureteral stenosis is preferred.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Percutaneous Nephrostomy and Hemodialysis in Patients with Obstructive Uropathy: A Clinical Trial Study

Khazaeli

Mombeini

Kord

et al. 2019

Jentashapir J Health Res

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Background: Obstructive uropathy disease is a potentially lethal disease caused by the urination disorder, which is of great importance to proper treatment. Objectives: Based on the mentioned section, the aim was to compare the results and complications of percutaneous nephrostomy with hemodialysis in correcting water and electrolyte disorders in patients with obstructive uropathy. Methods: In this as a clinical trial study, thirty patients with obstructive uropathy were considered as the study group. Patients were randomly divided into hemodialysis and PCN (percutaneous nephrostomy) groups. In both groups, BUN/Cr, Na, and K were measured every six hours. The variables T1 (time to preparation for action), T2 (time to clearance), T3 (total hospitalization time), pain score, satisfaction rate, and complications in both groups were compared. Finally, the data were analyzed using the SPSS software. Results: Results show that T1 in both PCN and hemodialysis groups was not significantly different. However, T2 and T3 in the PCN group had a significant decrease compared to the hemodialysis group, also the satisfaction rate in patients with PCN was better than hemodialysis. Concentration of potassium and creatinine in the PCN method decreased more than hemodialysis. However, there was no significant difference in the trend of reduction of other indicators such as sodium concentration, systolic, and diastolic blood pressure in both methods. Conclusions: PCN can be an alternative, appropriate, cheap, and less complicated method for patients with obstructive uropathy.

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Lage- und Verschmelzungsanomalien der Nieren, Doppelnieren, Ureterektopie und Ureterozele

Stein¹,

Vester

Szavay

2023

Die Kinder- Und Jugendurologie

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Detection of obstructive uropathy and assessment of differential renal function using two functional magnetic resonance urography tools

Cited by 7 publications

References 26 publications

Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Comparing the Percutaneous Nephrostomy and Hemodialysis in Patients with Obstructive Uropathy: A Clinical Trial Study

Lage- und Verschmelzungsanomalien der Nieren, Doppelnieren, Ureterektopie und Ureterozele

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