Detection of ovomucoid‐specific low‐affinity IgE in infants and its relationship to eczema

Kawamoto, Norio; Kamemura, Norio; Kido, Hiroshi; Fukao, Toshiyuki

doi:10.1111/pai.12702

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Furthermore, a strong association between food sensitization and atopic dermatitis and/or skin barrier impairment has been reported . We reported previously the presence of strong association between persistent eczema and high incidence of ovomucoid‐specific high‐affinity IgE in 14‐month‐old infants . The present longitudinal study of immunoglobulin isotype formation found low levels of IgG1, undetectable levels of IgG2 and high levels and high‐affinity IgE in the red circles infants, suggests that this type of immunoglobulin isotype formation is closely related to eczema history and could potentially be a biomarker of progression of food allergy.…”

Section: Discussionsupporting

confidence: 63%

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Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

Irahara

Shinahara

Sugimoto

et al. 2019

Immunity Inflam & Disease

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Introduction Allergen‐specific immunoglobulin isotype formation associated with immunoglobulin class‐switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type‐related egg‐ and milk‐specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Methods Allergen‐specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Results Formula and mixed feeding were associated with a rapid increase in cow's milk allergen‐specific immunoglobulins and feeding type‐related significant differences in casein‐specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin‐specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low‐ or high‐affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin‐specific IgG1 levels, detectable IgG2, and low‐affinity IgE, while the other had low ovalbumin‐specific IgG1 levels, undetectable IgG2, and high levels of high‐affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Conclusions Feeding practice‐related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high‐affinity IgE.

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Section: Discussionsupporting

confidence: 63%

“…For instance, correlation coefficient of casein‐specific IgE between UniCAP (kU A /L) and DCP microarray (BUe/mL) and its equation are shown in Figure S1. Based on the small volume of the blood sample and wide assay dynamic range, the DCP assay method has been used in several cohort studies …”

Section: Methodsmentioning

confidence: 99%

Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

Irahara

Shinahara

Sugimoto

et al. 2019

Immunity Inflam & Disease

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“…In Japan, persistent eczema is related to the development of high-affinity, but not low-affinity, IgE against ovomucoid. 31 Fruit and vegetable intake is not associated with asthma or chronic rhino-sinusitis in European adults. 32…”

Section: Food Allerg En Smentioning

confidence: 97%

“…In Japan, persistent eczema is related to the development of high‐affinity, but not low‐affinity, IgE against ovomucoid …”

Section: Food Allergensmentioning

confidence: 99%

Highlights and recent developments in food and drug allergy, and anaphylaxis in EAACI Journals (2017)

Eigenmann

Akdiş²,

Bousquet

et al. 2018

Pediatric Allergy Immunology

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This review highlights research advances and important achievements in food allergy, anaphylaxis, and drug allergy that were published in the Journals of the European Academy of Allergy and Clinical Immunology (EAACI) in 2017. Food allergy and anaphylaxis research have continued to rapidly accelerate, with increasing numbers of outstanding developments in 2017. We saw new studies on the mechanisms, diagnosis, prevention of food allergy, and novel food allergens. Drug hypersensitivity, as well as hereditary angioedema, has been highlighted in the present review as the focus of recent developments. The EAACI owns three journals: Allergy, Pediatric Allergy and Immunology (PAI), and Clinical and Translational Allergy (CTA). One of the major goals of the EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. This paper summarizes the achievements of 2017 in anaphylaxis, and food and drug allergy. K E Y W O R D Sanaphylaxis, drug allergy, food allergy, hypersensitivity

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Neonatal antigen-specific IgE measured by a highly sensitive method and its relationship to food allergy during infancy

Shibuya¹,

Saito

Irahara

et al. 2020

Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatri

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Detection of ovomucoid‐specific low‐affinity IgE in infants and its relationship to eczema

Abstract: Human infant peripheral blood contains allergen-specific low-affinity sIgE. Persistent eczema is related to the development of high-affinity, but not low-affinity, IgE.

Cited by 3 publications

References 29 publications

Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

Highlights and recent developments in food and drug allergy, and anaphylaxis in EAACI Journals (2017)

Neonatal antigen-specific IgE measured by a highly sensitive method and its relationship to food allergy during infancy

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