Detection of paraproteins in agar gel electrophoresis

Hulsing-Hesselink, E.; Cnossen-Groeneveld, M.L.; Klein, F.

doi:10.1016/0009-8981(67)90256-2

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Buffers and Solvents2

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1969

1970

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“…Paraproteins of high molecular weight that do not ordinarily migrate in agar gel do so when strong (0.lM) Verona1 buffer is used (600).…”

Section: Buffers and Solventsmentioning

confidence: 99%

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Electrophoresis

Strickland¹

1970

Anal. Chem.

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“…Paraproteins of high molecular weight that do not ordinarily migrate in agar gel do so when strong (0.lM) Verona1 buffer is used (600).…”

Section: Buffers and Solventsmentioning

confidence: 99%

“…The cyanate often present in urea can carbamoylate the A-terminal groups of globin, yielding an artifact with fast mobility (261). Paraproteins of high molecular weight that do not ordinarily migrate in agar gel do so when strong (0.1 Af) Veronal buffer is used (600).…”

Section: Buffers and Solventsmentioning

confidence: 99%

Electrophoresis

Strickland¹

1970

Anal. Chem.

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Therapy of Macroglobulinaemia

Pronk¹,

Klein²,

F³

et al. 1969

Journal of Internal Medicine

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The effects of treatment with alkylating agents and prednisone on the paraprotein level, the serum viscosity and the clinical symptoms have been studied in four cases of Waldenström's macroglobulinaemia and in one case of IgA myeloma. Although the treatment occasionally had some effect, no correlation was observed between the paraprotein level and the clinical condition in the four macroglobulinaemia cases. In the myeloma case there was some correlation, although osteolytic foci appeared at a time when the production of paraprotein was considerably suppressed. It appears that neither the paraprotein level nor the serum viscosity can be used with certainty as an indicator of the activity of the pathological process. It is suggested that the paraprotein may not always be the principal cause of the symptoms of Waldenström's macroglobulinaemia.

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Detection of paraproteins in agar gel electrophoresis

Cited by 2 publications

References 4 publications

Electrophoresis

Electrophoresis

Therapy of Macroglobulinaemia

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