Detection of Parvovirus B19 Infection in Thalasemic Patients in Isfahan Province, Iran

Nikoozad, Razieh; Mahzounieh, Mohammadreza; Ghorani, Mohammadreza

doi:10.5812/jjm.26590

Cited by 5 publications

(5 citation statements)

References 22 publications

(22 reference statements)

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“…Anti-parvovirus B19 seroprevalence was lower in transfused patients than controls (2.4% and 8.5%, respectively). Thus, our findings contrast with other studies where transfusion recipients had significantly higher rates of anti-parvovirus B19 IgG positivity than controls 5 33. We cannot exclude that a few controls consulting the OPD and the allergy and immunology department of the hospital suffered from HEV or parvovirus B19 infection and already had detectable IgG antibodies and/or that patients with thalassemia pay in general more attention to hygiene and disease prevention due to their fragile condition 34.…”

Section: Discussioncontrasting

confidence: 98%

Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study

Khounvisith¹,

Saysouligno²,

Souvanlasy³

et al. 2022

Arch Dis Child

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IntroductionChildren requiring multiple blood transfusions are at high risk of transfusion-transmissible infections (TTIs). Lao People’s Democratic Republic is a low-resource setting where donor blood screening faces challenges. This study aimed to determine the burden of TTIs in children in Vientiane Capital.Methods300 children with transfusion history and 300 controls were recruited. In addition, 49 newly diagnosed transfusion recipients were followed for up to 12 months. Serum was tested for hepatitis B surface antigen and IgG antibodies against parvovirus B19, hepatitis B, C and E viruses.ResultsThe patients had a similar prevalence of anti-hepatitis B core antibodies (56; 18.7%) and hepatitis B surface antigen (8; 2.7%) as the controls (58; 19.3% and 9; 3.0%, respectively). However, there was a higher prevalence of an antibody profile suggestive of hepatitis B vaccination (anti-hepatitis B surface antibody positive/anti-hepatitis B core antibody negative) in the transfused group (140/299; 46.8%) than in controls (77/300; 25.7%, p<0.01). All other markers were similar in the patients and controls or higher in the controls: anti-hepatitis C virus (2.7% and 3.3%, p=0.6), anti-hepatitis E virus (7.5% and 12.7%, p=0.006) and anti-parvovirus B19 (2.4% and 8.5%, p=0.001). The longitudinal cohort did not show an increase in any marker over time.ConclusionOur results suggest no significant role of TTIs in Lao children. The higher prevalence of the hepatitis B vaccination profile in transfusion recipients showed that recommendations to vaccinate before commencing transfusions is at least partially implemented, although there is room for improvement.

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Section: Discussioncontrasting

confidence: 98%

Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study

Khounvisith¹,

Saysouligno²,

Souvanlasy³

et al. 2022

Arch Dis Child

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“…The present study revealed a high prevalence of the viruses in the thalassemia major patients 37% (28/75) when compared with study done in Iran by Nikoozad Et al (16) , in this study the rate was 20% (6/30) .the difference may be due to the sample size of the. A small sample size will not provide a precise and reliable estimation of the prevalence and a larger sample size is needed to obtain a higher confidence level.…”

Section: Discussionsupporting

confidence: 43%

Detection of Parvovirus B19 in B-thalassemia Major Patients by Serological and Molecular Method

Sadah¹,

Al-marsome²

2020

MLU

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Introduction:Because to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as Beta thalassemia major leads to suppression of erythropoiesis, referred to as reticulocytopenia,which could be life threatening, The aim of the study was to determine the rate of occurrence of parvovirus (B19) in beta thalassemia major patient by using real time-PCR, Study the correlation between B19 virus and patient's descriptive data and the correlation between B19 viral load and IgG titer.Method: This case-control study was done to detect the presence of parvovirus B19 DNA in plasma samples and anti-IgG ELISA of patients with beta thalassemia major. The population consisted of 75 patients with beta-thalassemia major who attended the Aban Al-balady hospital in in the City of Baghdad and 75 healthy people as a control. Results:The prevalence of parvovirus B19 in our study population was 28 (37.3%) were positive for B19 DNA by quantitative polymerase chain reaction in which highly significant different P value (< 0.0001), Results of enzyme linked immunosorbent assays showed that IgG antibodies was positive in 16 (21.3%) compared with control group which was 7 (9.3%). According to statistical analysis the difference was in borderline between case and control group in prevalence of B19 virus. There was significant (P= 0.039) association correlation between B19 DNA and anti-IgG positivity, but were significant in WBC (P<0.0001). Conclusion:In study, B19 infections were discovered in patients with beta thalassemia major. Screening of such risky groups will significantly reduce the incidence and prevalence of B19 infection.

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“…The objective of the present study was to evaluate the prevalence of acute B19 infections in Iranian patients with beta thalassemia major through the detection of its DNA in their sera by real-time PCR. Nikoozad et al [12] reported a B19 DNA prevalence of 20% in 30 thalassemia major patients in Iran. However, our results show a reduction in prevalence (4%).…”

Section: Discussionmentioning

confidence: 99%

“…Only one epidemiological study on human parvovirus B19 infection in Iranian patients with thalassemia has been reported, in which the prevalence of parvovirus B19 infection was compared between thalassemia major patients and healthy subjects [12]. The lack of sufficient information about the relationship between active B19 infection and thalassemia in Iran underscores the necessity to determine the rate of active B19 infection in thalassemia major patients.…”

Section: Introductionmentioning

confidence: 99%

Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran

et al. 2017

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BackgroundDue to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran.MethodsThis cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time polymerase chain reaction assay.ResultsThe prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analysis of human parvovirus B19 revealed genotype I in these six patients.ConclusionIn this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and disease-prevention measures.

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Detection of Parvovirus B19 Infection in Thalasemic Patients in Isfahan Province, Iran

Cited by 5 publications

References 22 publications

Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study

Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study

Detection of Parvovirus B19 in B-thalassemia Major Patients by Serological and Molecular Method

Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran

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