Oxidants and Antioxidants
DOI: 10.1385/1-59259-274-0:247
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Detection of Peroxynitrite-Induced Protein and DNA Modifications

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Cited by 8 publications
(8 citation statements)
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“…They are formed initially in situ in the phospholipid domain of cell membranes subject to ROS attack and are then cleaved by phospholipases, released extracellularly, circulated, and excreted in urine. 25,30,31 A range of mass spectroscopic assays have emerged on the basis of authentic standards for individual F 2 iPs. [32][33][34][35][36][37][38] Current immunoassays directed against iPF 2␣ -III (also known as 8-iso PGF 2␣ ) are more commonly used.…”
Section: Monitoring Ros Formation In Vivomentioning
confidence: 99%
“…They are formed initially in situ in the phospholipid domain of cell membranes subject to ROS attack and are then cleaved by phospholipases, released extracellularly, circulated, and excreted in urine. 25,30,31 A range of mass spectroscopic assays have emerged on the basis of authentic standards for individual F 2 iPs. [32][33][34][35][36][37][38] Current immunoassays directed against iPF 2␣ -III (also known as 8-iso PGF 2␣ ) are more commonly used.…”
Section: Monitoring Ros Formation In Vivomentioning
confidence: 99%
“…Peroxynitrite readily reacts with proteins to form 3-nitrotyrosine, tyrosine dimers or oxidation of thiol groups [9][10][11][12] which can either lead to inactivation or enhanced degradation [13][14][15][16] of the proteins. Further, peroxynitrite can also cause adduct formation, oxidation and strand breaks in DNA [16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…Estos métodos continúan perfeccionándose y probablemente surjan nuevos marcadores que nos permitirán medir la acción de los RLO de una manera más exacta y precisa [21][22][23][24] .…”
Section: Monitorización De La Formación De Radicales Libres De Oxígenounclassified