Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents

Azuma, Takashi; Arima, Natsumi; Tsukada, Ai; Hirami, Satoru; Matsuoka, Rie; Moriwake, Ryogo; Ishiuchi, Hirotaka; Inoyama, Tomomi; Teranishi, Yusuke; Yamaoka, Misato; Mino, Yoshiki; Hayashi, Tetsuya; Fujita, Yoshikazu; Masada, Mikio

doi:10.1016/j.scitotenv.2015.12.157

Cited by 114 publications

(43 citation statements)

References 58 publications

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“…The concentrations are usually detected in the order of µg•L −1 and ng•L −1 [3]. The main sources of contamination are the hospitals [4] and domestic sewage effluents [1]. These drugs and their metabolites may contaminate groundwater, rivers, lakes, and wastewater treatment plants [5] [6].…”

Section: Introductionmentioning

confidence: 99%

Banana Peel for Acetylsalicylic Acid Retention

Ribeiro¹,

Silva²,

Cunha³

et al. 2016

JEP

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A method for adsorption involving banana peel (BP) was studied to remove the pollutant acetylsalicylic acid (ASA) in aqueous medium. The results show that bioadsorbent has satisfactory maximum adsorption capacity (2.29 mg/g) for removing this analgesic and anti-inflammatory drug in aqueous solution (pH 7.0) using the Langmuir mathematical model. The tested concentrations of this pollutant were higher than the levels commonly found in the aquatic environment. This and other results suggest the BP as an alternative to ASA removal in water contaminated with pharmaceuticals pollutants.

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Section: Introductionmentioning

confidence: 99%

Banana Peel for Acetylsalicylic Acid Retention

Ribeiro¹,

Silva²,

Cunha³

et al. 2016

JEP

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“…Recent studies have gradually made it clear that a wide variety of pharmaceutical ingredients are present in the water environment Azuma et al, 2016;Tiedeken et al, 2017;Vasquez et al, 2014 . The concentration level of these pharmaceutical ingredients in the water environment ranges from ng/L to µg/L, which is lower than the concentration level mg/L that exerts pharmacological action in the human body.…”

mentioning

confidence: 99%

Low-concentration Sorbic Acid Promotes the Induction of <i>Escherichia coli</i> into a Viable but Nonculturable State

et al. 2019

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The effect of food preservatives and sanitizers at low concentrations on the induction of Escherichia coli into a viable but nonculturable VBNC state was investigated. When E. coli was incubated in physiological saline at 37 , the viable cell count measured by plate counting was approximately 3-logs lower than that measured by flow cytometry after 30 days. This difference, and morphological changes in cells, confirmed the transition of E. coli into a VBNC state. Adding 10 µg/l of sorbic acid significantly promoted the induction of E. coli into a VBNC state. This effect was not seen with benzoic acid or sodium hypochlorite at the same concentration. Resuscitation of E. coli VBNC cells was successful when they were grown in nutrient broth containing sodium pyruvate. These results suggest that the presence of low concentrations of food additives in a food manufacturing environment may act as potential triggers for bacterial VBNC induction.

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“…Recent in-depth quantification of these drugs together with the other anticancer drugs was achieved by the simultaneous combination of procedures known as solid-phase extraction (SPE) and liquid chromatography-mass spectrometry (LC-MS/MS) [16,[45][46][47], with special care taken for differences in the protocols applied for the liquid and the solid samples. The concentration and purification steps of the anticancer drugs in the liquid samples were performed by SPE [13,31]. In the case of the river sediments and the suspended solids (solid state samples), solvent extraction of the adsorbed materials was achieved by sonication and filtration [31,48,49] prior to analysis.…”

Section: Selection Of Anticancer Drugs and Their Quantificationmentioning

confidence: 99%

“…PPCPs include different groups of compounds typified by their chemical characteristics, structure, mechanism of action, mode of action, and their therapeutic use to treat specific diseases. Particularly, anticancer drugs are emerging as an area of growing interest because of their promotion of a long lifespan via the suppression of human death through their use as a chemotherapy [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…At present, the pollution aspect of anticancer drugs in Japan has been analyzed only in the very limited area surrounding the Yodo River since 2009 [13,[28][29][30][31]. Their occurrence in the river water and sediments, including from hospital and sewage treatment effluents [13,28,32], their fate after discharge [31], and their attenuation properties [29,30], were reported in a separate fashion. The time has come to make an overview of the status of anticancer drugs in the environmental water of the Yodo River basin.…”

Section: Introductionmentioning

confidence: 99%

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Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan

Azuma

2018

Applied Sciences

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This article reviews the pollution status of anticancer drugs present in the Yodo River basin located in the Kansai district of Japan, covering both the soluble and insoluble (adsorbed on the river sediments and suspended solids) levels. Procedures ranging from sampling in the field and instrumental analytical methods to the data processing for mass balance estimation of the target basin are also described. All anticancer drugs concerned with this article were detected in sewage and river waters, where the presence of bicalutamide (BLT) was identified at considerably high concentrations (maximum 254 ng/L in the main stream, 151 ng/L in tributaries, and 1032 ng/L in sewage treatment plant (STP) effluents). In addition, sorption distribution coefficient (logKd) values showed a tendency to become higher in the silty sediments at Suita Bridge than in the sandy sediments at Hirakata Bridge; these trends were supported by the results of the laboratory-scale sorption experiment. STPs were concluded to be the main sources of the anticancer drug load in the river, and a mass flux evaluation revealed that the effect of attenuation in the river environment was small. The effectiveness of ozonation in the sewage treatment process for removal of these anticancer drugs was further confirmed. The present article should be of value for facilitating the environmental risk assessment of a wide range of drugs in a broader geographical area.

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Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents

Cited by 114 publications

References 58 publications

Banana Peel for Acetylsalicylic Acid Retention

Banana Peel for Acetylsalicylic Acid Retention

Low-concentration Sorbic Acid Promotes the Induction of <i>Escherichia coli</i> into a Viable but Nonculturable State

Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan

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