Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population

Shekhar, Sudhanshu; Sood, Surbhi; Showkat, Sadiya; Lite, Christy; Chandrasekhar, Anjalakshi; Vairamani, M.; Seetharaman, Barathi; Santosh, Winkins

doi:10.1016/j.ygcen.2016.05.025

Cited by 163 publications

(80 citation statements)

References 68 publications

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“…Until now, there have been several studies, which determine the burden of these compounds in human biological samples. Recently, BPA and TCS have been detected in urine (Arbuckle et al, ; Philippat et al, ), amniotic fluid (Philippat et al, ; Shekhar et al, ), meconium and breast milk (Arbuckle et al, ), blood (Shekhar et al, ), hair (Lee, Kim, Kim, & Cho, ; Martín, Möder, Gaudl, Alonso, & Reemtsma, ) and nails (TCS) (Shi, Liu, Zhang, & Shao, ). PFOA has been also detected in a variety of biological samples such as amniotic fluid, blood, urine, breast milk and hair (Al‐sheyab, Al‐Qudah, & Tahboub, ; Alves, Jacobs, Vanermen, Covaci, & Voorspoels, ; Genuis, Beesoon, & Birkholz, ; Stein, Wolff, Calafat, Kato, & Engel, ).…”

Section: Introductionmentioning

confidence: 99%

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Karzi

Tzatzarakis

Vakonaki

et al. 2018

J of Applied Toxicology

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Bisphenol A (BPA), triclosan (TCS) and perfluorooctanoic acid (PFOA) are endocrine disruptors linked with negative health effects such as developmental, reproductive and cardiovascular toxicity. The aim of this study was to determine simultaneously the concentration of BPA, TCS and PFOA in hair from children and adults and examine possible associations between biomonitoring data and age, gender, dietary habits and body mass index. Methanolic extraction was applied and the compounds were determined by liquid chromatography-mass spectrometry. Low levels of exposure to PFOA were detected for children and adults at concentrations below limit of quantification. The mean concentration of BPA in children and adults was 20.6 and 16.6 pg mg , while for TCS 275.2 and 687.0 pg mg , respectively. Children were highly exposed to BPA relative to adults (P = .011) although adults had greater exposure to TCS (P = .003). Hair from girls had a greater burden of BPA (P = .06) compared to boys. Moreover, higher TCS levels were depicted for females in both examined groups (children P = .200 and adults P = .213) compared to males, but no statistical differences were observed. Significant differences were also observed between age groups (P = .0007) for TCS. No correlations were found between BPA or TCS levels and body mass index or dietary habits for both children and adults. Children have a greater exposure to BPA compared to adults, whereas exposure of adults to TCS seems to be higher than that in children and elderly people. Exposure to BPA occurs mainly via ingestion whereas exposure to TCS mainly via dermal absorption.

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Section: Introductionmentioning

confidence: 99%

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Karzi

Tzatzarakis

Vakonaki

et al. 2018

J of Applied Toxicology

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“…Animals were housed and kept in polypropylene cages and Millipore‐filtered water was provided in glass bottles with Teflon seals to prevent possible background contamination of BPA. The drinking water was analyzed for BPA using gas chromatography–mass spectrometry and was found to contain levels below the mean analytical method blanks. A phytoestrogen‐free diet was provided ad libitum (Rodent Diet, AIN‐93G).…”

Section: Methodsmentioning

confidence: 99%

“…Our lab has recently reported the presence of nine phenolic EDCs along with BPA, from the amniotic fluid and maternal blood. BPA was detected in both maternal and fetal matrices . Since, early development is a hormone‐dependent period, exposure to BPA during early life stages results in long‐lasting effects.…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to bisphenol‐A altered miRNA‐224 and protein expression of aromatase in ovarian granulosa cells concomitant with elevated serum estradiol levels in F₁ adult offspring

Lite

Ahmed

Santosh

et al. 2019

J Biochem & Molecular Tox

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This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b, miRNA-378 and miRNA-224 were analyzed in ovarian granulosa cells. BPA affected the postnatal developmental landmarks such as weight of the pups at birth and reduced anogenital distance. BPA exposed animals showed elevated serum estradiol (E2) levels, while follicle-stimulating hormone levels were reduced. The expression of miRNA-224 and aromatase protein levels were found to be increased. This preliminary finding reveals the impact of early life exposure to BPA on the long-term ovarian functions that may be mediated through miRNA-based granulosa cell response. Besides, it is also a compelling indicator for the subclinical response that could have important consequences on female fertility.

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“…The increase in NP [8][9][10][11][12][13][14][15] EO level was probably due to the degradation of longer-chain oligomers. Indeed, higher oligomers with more than 15 ethoxylate groups such as NP 4-17 EO [7] and NP [35][36][37][38][39][40] EO [90] have been reported for textile wastewater. …”

Section: The Role Of Primary Coagulationmentioning

confidence: 99%

Distribution and Removal of Nonylphenol Ethoxylates and Nonylphenol from Textile Wastewater—A Comparison of a Cotton and a Synthetic Fiber Factory in Vietnam

Watanabe

2017

Water

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Abstract:The textile industry is a significant source of nonyphenol and their ethoxylates, which are suggested to be responsible for endocrine disruption in wildlife and humans. This study is a comparison of two conventional wastewater treatment processes in a cotton and a synthetic fiber factory in Vietnam, with regard to the distribution and removal of nonyphenol ethoxylates and nonyphenol throughout each process. Diverse trends in the distribution of nonyphenol ethoxylates in wastewater from factories, distinguished by their raw materials, could be revealed. Primary coagulation might not perfectly facilitate nitrification in the secondary activated sludge process regarding pH. Nevertheless, satisfactory removals were achieved during coagulation and activated sludge processes in both systems. The roles of long hydraulic retention times (21 and 16 h, respectively), low organic loadings (0.1 and 0.2 gCOD/gMLVSS.day, respectively), extended solids retention times (61 and 66 days, respectively), and mixed liquor suspended solids of greater than 2000 mg/L have been demonstrated. The findings provide evidence and a better understanding of nonyphenol ethoxylate and nonyphenol removal efficacy as well as influencing factors in Vietnamese textile wastewater treatment. The results are beneficial for the textile industry in Vietnam regarding investment decisions for wastewater treatment.

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Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population

Cited by 163 publications

References 68 publications

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Prenatal exposure to bisphenol‐A altered miRNA‐224 and protein expression of aromatase in ovarian granulosa cells concomitant with elevated serum estradiol levels in F₁ adult offspring

Distribution and Removal of Nonylphenol Ethoxylates and Nonylphenol from Textile Wastewater—A Comparison of a Cotton and a Synthetic Fiber Factory in Vietnam

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Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population

Cited by 163 publications

References 68 publications

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults

Prenatal exposure to bisphenol‐A altered miRNA‐224 and protein expression of aromatase in ovarian granulosa cells concomitant with elevated serum estradiol levels in F1 adult offspring

Distribution and Removal of Nonylphenol Ethoxylates and Nonylphenol from Textile Wastewater—A Comparison of a Cotton and a Synthetic Fiber Factory in Vietnam

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Prenatal exposure to bisphenol‐A altered miRNA‐224 and protein expression of aromatase in ovarian granulosa cells concomitant with elevated serum estradiol levels in F₁ adult offspring