Detection of plasmonic nanoparticles with full field-OCT: optical and photothermal detection

Nahas, Amir; Varna, Mariana; Fort, Emmanuel; Boccara, A. C.

doi:10.1364/boe.5.003541

Cited by 20 publications

(20 citation statements)

References 23 publications

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“…We will end our examples of multimodal approaches; other examples can be found in reference 4 and include in particular photothermal effects that become important with the contrast induced by various kinds of nano particles [123,124].…”

Section: Elastic Propertiesmentioning

confidence: 99%

En face coherence microscopy [Invited]

Thouvenin¹,

Grieve²,

Xiao³

et al. 2017

Biomed. Opt. Express

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En face coherence microscopy or flying spot or full field optical coherence tomography or microscopy (FF-OCT/FF-OCM) belongs to the OCT family because the sectioning ability is mostly linked to the source coherence length. In this article we will focus our attention on the advantages and the drawbacks of the following approaches: en face versus B scan tomography in terms of resolution, coherent versus incoherent illumination and influence of aberrations, and scanning versus full field imaging. We then show some examples to illustrate the diverse applications of en face coherent microscopy and show that endogenous or exogenous contrasts can add valuable information to the standard morphological image. To conclude we discuss a few domains that appear promising for future development of en face coherence microscopy. tomography with a Linnik microscope," Appl. Opt. 41, 805-812 (2002). 6. L. Vabre, A. Dubois, and A. C. Boccara, "Thermal-light full-field optical coherence tomography," Opt. Lett. 27(7), 530-532 (2002). 7. Handbook of Full-Field Optical Coherence Microscopy: Technology and Applications; Arnaud Dubois editor.Pan Stanford 2016. 8. M. Akiba, K. P. Chan, and N. Tanno, "Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras," Opt. Lett. 28(10), 816-818 (2003). 9. L. Yu and M. Kim, "Full-color three-dimensional microscopy by wide-field optical coherence tomography," Opt.Express 12(26), 6632-6641 (2004 Hüttmann, "In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography," Opt. Lett. 41(21), 4987-4990 (2016). 44. M. Villiger, C. Pache, and T. Lasser, "Dark-field optical coherence microscopy," Opt. Lett. 35(20), 3489-3491 (2010). 45. E. Auksorius and A. C. Boccara, "Dark-field full-field optical coherence tomography," Opt. Lett. 40(14), 3272-3275 (2015 4948-4956 (2008). 107. C.-E. Leroux, F. Bertillot, O. Thouvenin, and A.-C. Boccara, "Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport," Biomed. Opt. Express 7(11), 4501-4513 (2016). 108. J. Schmitt, "OCT elastography: imaging microscopic deformation and strain of tissue," Opt. Express 3(6), 199-211 (1998

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Section: Elastic Propertiesmentioning

confidence: 99%

En face coherence microscopy [Invited]

Thouvenin¹,

Grieve²,

Xiao³

et al. 2017

Biomed. Opt. Express

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“…95 Gold nanoparticles have been explored for use in OCT, either through detection of their absorption signature 96 or by photothermal excitation 97 or both. 98 Recent extension to in vivo use in an animal model has shown the potential of gold nanoparticles as an imaging contrast agent but did not demonstrate molecular specificity. 99 …”

Section: Molecular Imaging In Octmentioning

confidence: 99%

Functional optical coherence tomography: principles and progress

et al. 2015

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In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the literature. SOCT elucidates tissue characteristics, such as oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and scattering of light in tissues. While SOCT measures endogenous biochemical distributions, molecular imaging OCT detects exogenous molecular contrast agents. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to understand tissue activity that cannot be accomplished by other current imaging methodologies.

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“…Some FF-OCT multimodal systems have been reviewed in the recently published Handbook of Full-Field Optical Coherence Microscopy, edited by Arnaud Dubois [16]. We can non-exhaustively mention the multimodal combinations of FF-OCT with fluorescence [18], photothermal imaging [19], elastography [20], polarization [21], multispectral and hyperspectral imaging [22][23][24]. Most of these multimodal systems have been inspired by similar systems developed in standard OCT, but they needed to be adapted and redesigned to fit FF-OCT's particular configuration.…”

Section: Introductionmentioning

confidence: 99%

Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

et al. 2017

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Full-field optical coherence tomography (FF-OCT) is a variant of OCT that is able to register 2D en face views of scattering samples at a given depth. Thanks to its superior resolution, it can quickly reveal information similar to histology without the need to physically section the sample. Sensitivity and specificity levels of diagnosis performed with FF-OCT are 80% to 95% of the equivalent histological diagnosis performances and could therefore benefit from improvement. Therefore, multimodal systems have been designed to increase the diagnostic performance of FF-OCT. In this paper, we will discuss which contrasts can be measured with such multimodal systems in the context of ex vivo biological tissue examination. We will particularly emphasize three multimodal combinations to measure the tissue mechanics, dynamics, and molecular content respectively.

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Detection of plasmonic nanoparticles with full field-OCT: optical and photothermal detection

Cited by 20 publications

References 23 publications

En face coherence microscopy [Invited]

En face coherence microscopy [Invited]

Functional optical coherence tomography: principles and progress

Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

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