“…For example, a SNP (rs3135388) that was previously associated with multiple sclerosis was also found to be associated with erythematous conditions. Several recent studies have successfully exploited PheWAS to identify novel SNP-disease associations [54,57,59,64,66,67]. Whereas GWAS focuses on only one disease at a time, PheWAS has the ability to measure genetic associations with potentially thousands of traits and diseases simultaneously, enabling systematic detection of genetic variants with pleiotropic effects [56,58,67].…”