2023
DOI: 10.1101/2023.07.31.551307
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Detection of prions from spiked and free-ranging carnivore feces

H. N. Inzalaco,
E. E. Brandell,
S.P. Wilson
et al.

Abstract: Chronic wasting disease (CWD) is a highly contagious, fatal neurodegenerative disease caused by infectious prions (PrPCWD) affecting wild and captive cervids. Although experimental feeding studies have demonstrated prions in feces of crows (Corvus brachyrhynchos), coyotes (Canis latrans), and cougars (Puma concolor), the role of scavengers and predators in CWD epidemiology remains poorly understood. Here we applied the real-time quaking-induced conversion (RT-QuIC) assay to detect PrPCWD in feces from cervid c… Show more

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