Detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: A comparative study

Arangannal, Ponnudurai; Santoshkumari,; Krishnan, Padma; Nichani, Mamta Harilal; Mahalakshmi, Krishnan; Chamarthi, V

doi:10.4103/0970-9290.118000

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…Barring our earlier study, hardly there are any previous reports correlating T1DM and periodontitis with regard to the prevalence of periodontal bacterial pathogens [12]. The aim of the present study was to compare the prevalence and assess the risk of four other key periodontopathic bacteria viz., Eikenella corrodens , Campylobacter rectus , Prevotella intermedia and Prevotella nigrescens among the type 1 diabetic children and healthy children/adolescents between the age group of 7 and 14 years, using polymerase chain reaction.…”

Section: Introductionmentioning

confidence: 73%

Frequency of putative periodontal pathogens among type 1 diabetes mellitus: a case–control study

2019

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Objective The aim of the present study is to compare and assess the risk of periodontitis due to the presence of four putative periodontopathic bacteria viz., Eikenella corrodens , Campylobacter rectus , Prevotella intermedia and Prevotella nigrescens . To fulfil the above objective, polymerase Chain reaction using the primers targeting 16S rRNA gene of the bacterial species was performed with the subgingival plaque collected from the permanent first molars of type 1 diabetic children and age matched healthy children. Results The prevalence of periodontal pathogens in diabetic and healthy children was 6% and 16% for E. corrodens , 18% and 36% for C. rectus , 2% and 2% for P. intermedia , 4% and 0%, for P. nigrescens respectively. Statistically, significant difference was not observed for the prevalence of all the four periodontal pathogens between type 1 diabetic and healthy children (P = 1.00). The results of the present study thus reveal a negative correlation of type I diabetes to periodontitis in association to Eikenella corrodens , Campylobacter rectus , Prevotella intermedia and Prevotella nigrescens .

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Section: Introductionmentioning

confidence: 73%

Frequency of putative periodontal pathogens among type 1 diabetes mellitus: a case–control study

2019

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“…Other studies found no significant difference in the prevalence of putative periodontopathic bacteria between T1DM and healthy children, challenging the notion of an increased risk of periodontitis associated with specific bacterial species in T1DM subjects (Arangannal et al, 2013). Similarly, Lalla et al (2015), suggested similar subgingival infection patterns between individuals with T1DM and healthy controls, particularly under controlled periodontal disease severity conditions (Lalla et al, 2015).…”

Section: Type 1 Diabetes Mellitus and Oral Microbiotamentioning

confidence: 98%

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Vlachou,

Loume,

Giannopoulou

et al. 2024

Preprint

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Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected to rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes mellitus (T1DM), focusing on cellular and molecular mechanisms derived by the interplay between oral microbiota and the host immune response. A comprehensive search of literature published between 2008 and 2023 was conducted to elucidate the association between these two diseases. Preclinical and clinical evidence suggests a bidirectional relationship, with individuals with T1DM exhibiting heightened susceptibility to periodontitis, and vice versa. The review includes recent findings from human clinical studies, revealing variations in oral microbiota composition in T1DM patients, including increases in certain pathogenic species such as Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans, along with shifts in microbial diversity and abundance. Molecular mechanisms underlying this association involve oxidative stress and dysregulated host immune responses, mediated by inflammatory cytokines such as IL-6, IL-8, and MMPs. Furthermore, disruptions in bone turnover markers, such as RANKL and OPG, contribute to periodontal complications in T1DM patients. While preventive measures to manage periodontal complications in T1DM patients may improve overall health outcomes, further research is needed to understand the intricate interactions between oral microbiota, host response, periodontal disease, and systemic health in this population.

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Detection of selected periodontal bacteria in preschool children affected by early childhood caries

et al. 2016

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The aim of this study was to compare the detection frequency of periodontal bacteria in dental plaque in children with early childhood caries (ECC) with and without gingival inflammation. A convenience sample of 25 preschool children (mean age 3.61 years, SD 1.42) was recruited. Dental plaque was taken from periodontal areas with and without visible signs of inflammation and processed using the StomaGene® (Protean s.r.o. Czech Republic) and ParoCheck® 20 (Greiner Bio-one GmbH, Germany) detection kits. The two sample t tests between percents for differences between inflammatory and healthy sites and kappa statistics for the agreement of both systems were used. At the inflammatory sites, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans were significantly more frequently detected by StomaGene® while Fusobacterium nucleatum, A. actinomycetemcomitans, Tanarella forsythia and Prevotella intermedia were significantly more frequently identified by ParoCheck® test. The agreement between the two detection systems was substantial for A. actinomycetemcomitans and F. nucleatum in the samples collected from inflamed sites and only for F. nucleatum from clinically healthy sites. Therefore, we recommend that the same system should be used when the same patient is examined repeatedly.

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Detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: A comparative study

Abstract: Statistical significance was not observed for the prevalence of periodontopathic bacteria in type 1 diabetic subjects. The results of the present study thus reveal the absence of risk of periodontitis by these bacterial species in type 1 diabetic subjects.

Cited by 7 publications

References 29 publications

Frequency of putative periodontal pathogens among type 1 diabetes mellitus: a case–control study

Frequency of putative periodontal pathogens among type 1 diabetes mellitus: a case–control study

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Detection of selected periodontal bacteria in preschool children affected by early childhood caries

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