Detection of resting state functional connectivity using partial correlation analysis: A study using multi-distance and whole-head probe near-infrared spectroscopy

Sakakibara, Eisuke; Homae, Fumitaka; Kawasaki, Shingo; Nishimura, Yukika; Takizawa, Ryu; Koike, Shinsuke; Kinoshita, Akihide; Sakurada, Hanako; Yamagishi, Mika; Nishimura, Fumichika; Yoshikawa, Akane; Inai, Aya; Nishioka, M.; Eriguchi, Yosuke; Matsuoka, Jun; Satomura, Yoshihiro; Okada, Naohiro; Kakiuchi, Chihiro; Araki, Tsuyoshi; Kan, Chiemi; Umeda, Masahiro; Shimazu, Akihito; Uga, Minako; Dan, Ippeita; Hashimoto, Hideki; Kawakami, Norito; Kasai, Kiyoto

doi:10.1016/j.neuroimage.2016.08.011

Cited by 40 publications

(46 citation statements)

References 57 publications

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“…In addition, the topological features from the frequency networks can provide insights how atherosclerotic diseases affect spontaneous hemodynamic activity. For example, most of functional connectivity studies with NIRS in healthy subjects show inter-hemispheric connections (Li et al, 2015;Mesquita et al, 2010;Novi et al, 2016;Sakakibara et al, 2016). In this study we were also able to find similarities between hemispheres for all of the patients, which resulted in interhemispheric connections.…”

Section: Discussionsupporting

confidence: 67%

Use of near-infrared spectroscopy to probe occlusion severity in patients diagnosed with carotid atherosclerotic disease

Forero

Novi

Avelar

et al. 2017

MRAJ

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Abstract:Atherosclerotic disease has been associated with increased risk of severe neurovascular consequences including transient ischemic attacks, ischemic strokes, and even mortality. Following the onset of carotid stenosis, the brain undergoes different compensatory mechanisms to provide adequate perfusion in order to maintain brain metabolism. In this study, we employed near-infrared spectroscopy (NIRS) to better comprehend how carotid stenosis affects cerebral hemodynamics, both at rest and during activity. Eighteen patients diagnosed with atherosclerotic disease were recruited for a protocol consisting of resting state and vasoreactivity testing performed with breath holding. Although the breath holding challenge induced global vasodilation in all patients, the extent of dilation varied according to the level of stenosis. Patients diagnosed with carotid stenosis have impaired hemodynamic response, with a median 77% vasoreactivity in the hemisphere ipsilateral to the stenotic vessel when compared to the healthy hemisphere. Hemodynamics of these patients differed at rest, with 33% fewer network links in the hemisphere ipsilateral to the stenosis than the healthy hemisphere. On the other hand, hemodynamic patterns were more heterogeneous with patients diagnosed with a carotid occlusion, which correlates with the opening of collateral circulation. Overall, our results suggest that NIRS can open new directions to the investigation of the effects of cerebrovascular atherosclerotic disease.

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Section: Discussionsupporting

confidence: 67%

Use of near-infrared spectroscopy to probe occlusion severity in patients diagnosed with carotid atherosclerotic disease

Forero

Novi

Avelar

et al. 2017

MRAJ

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“…However, there is a possibility that an increase in RPE during exercise would cause increases in MAP and CO, resulting in an increase in cortical Oxy-Hb (Ide et al 2000;Ogoh et al 2005;Ogoh and Ainslie, 2009). To examine the degree of relationship between the RPE and the late Oxy-Hb responses after excluding the effects of MAP and CO on the Oxy-Hb response, we conducted partial correlation analysis (with a sample size of 40) that measures the degree of a linear relationship between two variables while controlling for the effect of one or more other variables as used previously (Bohnen et al 2009;Sakakibara et al 2016). The partial correlation between the RPE and the Oxy-Hb response is the correlation between the residuals (R RPE and R Oxy-Hb ) resulting from the linear regression of the RPE with MAP and CO and of the Oxy-Hb with MAP and CO, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…; Sakakibara et al . ). The partial correlation between the RPE and the Oxy‐Hb response is the correlation between the residuals ( R RPE and R Oxy‐Hb ) resulting from the linear regression of the RPE with MAP and CO and of the Oxy‐Hb with MAP and CO, respectively.…”

Section: Methodsmentioning

confidence: 97%

“…The oxygenation responses in the PM-SMA and sensorimotor areas were expected to increase in association with exercise intensity (Dai et al 2001;Derosière et al 2014). A partial correlation analysis was used to examine the relationship between the subjective degree of motor effort and the oxygenation responses after statistically reducing the effects of systemic haemodynamic changes on the oxygenation responses (Sakakibara et al 2016). Furthermore, to isolate an influence of mechanical afferents by rhythmic arm movement on the cortical oxygenation, we examined the oxygenation responses of the frontal and frontoparietal areas during motor-driven passive one-armed cranking.…”

Section: Introductionmentioning

confidence: 99%

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Feedforward‐ and motor effort‐dependent increase in prefrontal oxygenation during voluntary one‐armed cranking

Ishii

Liang

Asahara

et al. 2018

The Journal of Physiology

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Output from higher brain centres (termed central command) regulates the cardiovascular system during exercise in a feedforward- and motor effort-dependent manner. This study aimed to determine a cortical area responding prior to arbitrarily started exercise and in proportion to the effort during exercise. The oxygenation responses in the frontal and frontoparietal areas during one-armed cranking with the right arm were measured using multichannel near-infrared spectroscopy, as indexes of regional blood flow responses, in 20 subjects. The intensity of voluntary exercise was 30% and 60% of the maximal voluntary effort (MVE). At the start period of both voluntary cranking tasks, the oxygenation increased (P < 0.05) only in the lateral and dorsal part of the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC) and sensorimotor cortices. Then, the oxygenation increased gradually in all cortical areas during cranking at 60% MVE, while oxygenation increased only in the frontoparietal area and some of the frontal area during cranking at 30% MVE. The rating of perceived exertion to the cranking tasks correlated (P < 0.05) with the oxygenation responses on the right side of the lateral-DLPFC (r = 0.46) and VLPFC (r = 0.48) and the frontopolar areas (r = 0.47-0.49). Motor-driven passive one-armed cranking decreased the oxygenation in most cortical areas, except the contralateral frontoparietal areas. Accordingly, the lateral-DLPFC and VLPFC on the right side would respond in a feedforward- and motor effort-dependent manner during voluntary exercise with the right arm. Afferent inputs from mechanosensitive afferents may decrease the cortical oxygenation.

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“…32 Similarly, FC analysis with the PC approach has been proposed both by our group and others. 17,23,33,34 Our group has shown that using the remaining 14 channels of a 16-channel fNIRS measurement system as the regressors of the PC analysis, we can provide reliable estimate of the FC analysis. The assumption behind this approach was that there are local systemic fluctuations at each measurement site (channel) and they are also picked up by any channel.…”

mentioning

confidence: 99%

Partial correlation-based functional connectivity analysis for functional near-infrared spectroscopy signals

Akın

2017

J. Biomed. Opt

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A theoretical framework, a partial correlation-based functional connectivity (PC-FC) analysis to functional near-infrared spectroscopy (fNIRS) data, is proposed. This is based on generating a common background signal from a high passed version of fNIRS data averaged over all channels as the regressor in computing the PC between pairs of channels. This approach has been employed to real data collected during a Stroop task. The results show a strong significance in the global efficiency (GE) metric computed by the PC-FC analysis for neutral, congruent, and incongruent stimuli (NS, CS, IcS; GEN=0.10±0.009, GEC=0.11±0.01, GEIC=0.13±0.015, p=0.0073). A positive correlation (r=0.729 and p=0.0259) is observed between the interference of reaction times (incongruent-neutral) and interference of GE values (GEIC-GEN) computed from [HbO] signals.

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Detection of resting state functional connectivity using partial correlation analysis: A study using multi-distance and whole-head probe near-infrared spectroscopy

Cited by 40 publications

References 57 publications

Use of near-infrared spectroscopy to probe occlusion severity in patients diagnosed with carotid atherosclerotic disease

Use of near-infrared spectroscopy to probe occlusion severity in patients diagnosed with carotid atherosclerotic disease

Feedforward‐ and motor effort‐dependent increase in prefrontal oxygenation during voluntary one‐armed cranking

Partial correlation-based functional connectivity analysis for functional near-infrared spectroscopy signals

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