Detection of rotavirus in children with acute gastroenteritis in Porto Velho, Rondonia, Brazil

Sandra, Cuello; Estevam, G. K.; Penati, M.; Soares, Leidiane Amorim; Ferreira, Rafael Batista; Orlandi, Patrícia Puccinelli; Najla, B. M.

doi:10.1007/s00705-013-1847-8

Cited by 4 publications

(2 citation statements)

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“…Twelve studies from upper-middle income countries (Argentina [ 24 ], Brazil [ 8 , 10 , 25 – 31 ], Mexico [ 32 ], and Venezuela [ 33 ]) and lower-middle income countries (Bolivia [ 34 ], El Salvador [ 35 ], and Nicaragua [ 36 – 41 ]), involving 15 750 children were included for the overall analysis of VE. These included 2 102 (17.4 %) rotavirus-positive cases among 12 079 vaccinated and 996 (27.1 %) rotavirus-positive cases among 3 671 unvaccinated children.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and meta-analysis

et al. 2016

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BackgroundRotavirus was the leading cause of childhood diarrhoea-related hospitalisations and death before the introduction of rotavirus vaccines.MethodsWe describe the effectiveness of rotavirus vaccines to prevent rotavirus infections and hospitalizations and the main rotavirus strains circulating before and after vaccine introduction through a systematic review and meta-analysis of studies published between 1990 and 2014. 203 studies were included to estimate the proportion of infections due to rotavirus and 10 to assess the impact of the vaccines. 41 of 46 studies in the post-vaccination period were used for meta-analysis of genotypes, 20 to calculate VE against infection, eight for VE against hospitalisation and seven for VE against severe rotavirus-diarrhoea.Results24.3 % (95 % CI 22.1–26.5) and 16.1 % (95 % CI 13.2–19.3) of cases of diarrhoea were due to rotavirus before and after vaccine introduction, respectively. The most prevalent G types after vaccine introduction were G2 (51.6 %, 95 % CI 38–65), G9 (14.5 %, 95 % CI 7–23) and G1 (14.2 %, 95 % CI 7–23); while the most prevalent P types were P[4] (54.1 %, 95 % CI 41–67) and P[8] (33 %, 95 % CI 22–46). G2P[4] was the most frequent genotype combination after vaccine introduction. Effectiveness was 53 % (95 % CI 46–60) against infection, 73 % (95 % CI, 66–78) against hospitalisation and 74 % (95 % CI, 68.0–78.0) against severe diarrhoea. Reductions in hospitalisations and mortality due to diarrhoea were observed in countries that adopted universal rotavirus vaccination.ConclusionsRotavirus vaccines are effective in preventing rotavirus-diarrhoea in children in Latin America. The vaccines were associated with changes in genotype distribution.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-016-0173-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and meta-analysis

et al. 2016

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“…The medical importance of RVA is well established and, for this reason, since March of 2006, the Rotarix (r) vaccine has been included in the Brazilian National Immunisation Program (NIP). There has been a subsequent reduction in hospital admissions due to gastroenteritis in most regions of Brazil, most likely due to the efficacy of this vaccine ( Borges et al 2011 , do Carmo et al 2011 , Sandra et al 2013 ).…”

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The prevalence of norovirus, astrovirus and adenovirus infections among hospitalised children with acute gastroenteritis in Porto Velho, state of Rondônia, western Brazilian Amazon

Amaral

Estevam

Penatti

et al. 2015

Mem. Inst. Oswaldo Cruz

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Although viruses are well-established causes of acute gastroenteritis, few data on the circulation of these pathogens in Porto Velho, state of Rondônia, Brazil, are available. Thus, faecal samples from hospitalised diarrhoeic children, under six years of age, were collected and tested for the presence of norovirus (NoV), adenovirus (AdV) and astrovirus (AstV) from February 2010-February 2012. Specimens were screened by reverse-transcription polymerase chain reaction and viruses were found in 10.7% (63/591) of the cases. NoV, AdV and AstV were detected in 7.8%, 2% and 0.8% of the samples, respectively. NoV infection was observed at all ages and was most prevalent in zero-18-month-old children (84.7%; p = 0.002). A higher incidence of NoV was detected from February-April 2010, when it was found in 52.2% of the cases. Co-infections involving these viruses, rotavirus and enteropathogenic bacteria were detected in 44.4% (28/63) of the children with viral diarrhoea. Nosocomial infections were demonstrated in 28.6% (18/63) of the cases in which viruses were detected. The present paper reports, for the first time, the circulation of NoV and AstV among the paediatric population of Porto Velho and it contributes to our understanding of the roles of these pathogens in gastrointestinal infections.

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Time-trend analysis of the impact of universal rotavirus vaccination in Brazil

Mathew

2016

Indian Pediatr

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Detection of rotavirus in children with acute gastroenteritis in Porto Velho, Rondonia, Brazil

Cited by 4 publications

References 25 publications

Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and meta-analysis

Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and meta-analysis

The prevalence of norovirus, astrovirus and adenovirus infections among hospitalised children with acute gastroenteritis in Porto Velho, state of Rondônia, western Brazilian Amazon

Time-trend analysis of the impact of universal rotavirus vaccination in Brazil

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