Detection of S-100 protein in melanocytic and neurogenic cutaneous tumors

Yambe, H.; Ishii, Yoshifumi; Isobe, T; Kikuchi, Kokichi

doi:10.1007/bf00414013

Cited by 10 publications

(2 citation statements)

References 23 publications

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“…An important finding is the presence of long cytoplasmic processes typical of Schwann cells, with interdigitations and a tendency to envelop other structures. Melanomas and melanocytic schwannomas stain positively for S100, indicating neural crest origin [13,18,23,24]. Both also stain positively for HMB-45, MART-1, and TA99, indicating the presence of melanosomal components.…”

Section: Distinction Between Melanoma and Melanocytic Schwannomamentioning

confidence: 90%

Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature

Kaehler

Russo²,

Katenkamp³

et al. 2008

Melanoma Research

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Melanocytic schwannoma is a rare soft-tissue tumor, which arises most commonly in the paraspinal sympathetic chain. In general, 25% of the patients develop metastasis. To date, only 17 cases of a cutaneous and subcutaneous melanocytic schwannoma have been reported. None of these patients developed metastasis. Three cases of cutaneous melanocytic schwannoma, diagnosed in our institution are reported. For further literature overview we performed a search on Medline using the terms 'melanocytic schwannoma' or 'melanotic schwannoma' or 'Carney complex' combined with 'skin' or 'cutaneous', for the period 1970-2007. Seventeen patients were described to have melanocytic schwannoma of the skin or subcutaneous tissues. These papers were reviewed for clinical data. Two of the three patients showed metastatic disease, one of them died of disseminated metastases. In contrast, none of the reported cases of cutaneous or subcutaneous melanocytic schwannomas was characterized by a malignant course. The differential diagnosis, especially with regard to malignant melanoma, is made by histology and by its clinical course, which differs from melanoma in its tendency to recur at the site of excision and slow rate of growth. Commonly misdiagnosed as melanoma, this tumor reveals insights into the origin of both melanocytes and Schwann cells. It is likely that the biological bases for melanoma and melanocytic schwannoma differ. It is necessary to differentiate this tumor from melanoma because of the differing prognosis and the association of melanocytic schwannoma with the Carney complex. Owing to the lack of clinical trials, we recommend that patients be treated according to the existing guidelines for melanoma.

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Section: Distinction Between Melanoma and Melanocytic Schwannomamentioning

confidence: 90%

Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature

Kaehler

Russo²,

Katenkamp³

et al. 2008

Melanoma Research

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“…In the present study, the immunocytochemical staining pattern of Melan-A was much more specific for melanoma cells than the staining with S-100. S-100 protein was originally considered to be specific for the nervous system (Moore, 1965) and was proposed as a valuable marker in the diagnosis of malignant melanoma and neurogenic tumours in humans (Nakajima et al, 1982;Yambe et al, 1984). However, S-100 is a widespread protein in human tissues (Kahn et al, 1983).…”

mentioning

confidence: 99%

Use of Immunocytochemical Techniques in Canine Melanoma

Höinghaus

Mischke

Hewicker‐Trautwein³

2002

Journal of Veterinary Medicine Series A

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The staining patterns of the monoclonal antibodies S-100 and Melan-A in canine melanoma were assessed based on cytological specimens of six canine melanomas (four benign, two malignant). In addition, eight regional lymph nodes of the two dogs with malignant melanomas were stained using these markers. For reference, all specimens were also evaluated immunohistochemically using S-100 and Melan-A. To assess the immunocytochemical specificity of both antibodies, various canine tumours and normal tissues were stained. The immunocytochemical staining results of the canine melanomas and the regional lymph nodes showed high conformity with the immunohistochemical reactivity patterns for S-100 and Melan-A. The specificity of Melan-A was higher compared with S-100. Melan-A, in particular, may be helpful for the cytological diagnosis of canine melanoma.

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S100 protein positive human breast carcinomas: An immunohistochemical study

Matsushima

Mori

Adachi

et al. 1994

Journal of Surgical Oncology

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An immunohistochemical study for S100 protein was performed on 95 human breast carcinomas. S100 protein positive carcinoma cells were recognized in 54 cases (57%). The S100 protein positive and negative carcinomas were then compared in terms of stage, histologic type, nuclear grade, appearance of minute calcification, immunoreactivity for estrogen receptor (ER), tumor recurrent pattern, and prognosis. The S100 protein positive cases had a tendency to show a low nuclear grade (P < 0.01). They were also more often seen in the ER positive group. For further analysis of the nature of S100 protein positive carcinoma cells, immunoreactivity for neuron-specific enolase (NSE) and actin was investigated. The positive staining for NSE and actin was seen in 46 cases (48%) and 3 cases (3%), respectively. There was, however, no specific correlation among the S100 protein. NSE, or actin staining. The nature of S100 protein positive carcinoma cells still remains unclear. The S100 protein positive carcinomas, however, exhibit relatively better characteristics.

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Detection of S-100 protein in melanocytic and neurogenic cutaneous tumors

Cited by 10 publications

References 23 publications

Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature

Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature

Use of Immunocytochemical Techniques in Canine Melanoma

S100 protein positive human breast carcinomas: An immunohistochemical study

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