Detection of Schmallenberg virus in different<i>Culicoides</i>spp. by real-time RT-PCR

Regge, Nick De; Deblauwe, Isra; Deken, R. De; Vantieghem, Pieter; Madder, Maxime; Geysen, Dirk; Smeets, François; Losson, Bertrand; Berg, Thierry van den; Cay, Ann Brigitte

doi:10.1111/tbed.12000

Cited by 180 publications

(167 citation statements)

References 16 publications

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“…Culicoides obsoletus -a major species of interest for virus transmission in northern Europe (Carpenter et al, 2008;De Regge et al, 2012) -seems to have a wide host range, and is likely to be particularly interested in humans under field conditions. This species showed mammalophilic preferences (mainly for humans) in the field experiments -probably caused by greater emission of carbon dioxide -but ornithophilic and mammalophilic preferences (chicken and sheep) based on VOCs released from skin surfaces in the laboratory experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Behavioural studies using olfactometers or wind or flight tunnels in which a specific number of biting insects are released are very rare (Bhasin et al, 2000b) due to the difficulty of obtaining a sufficient number of insects, given the complexity of maintaining many Culicoides species of interest under controlled conditions. Only a few speciesof limited interest in northern Europe -are commonly bred (Jones, 1964;Fahrner and Barthelmess, 1988;Kremer and Lienhart, 1998), and these do not include species of the subgenus Avaritia (particularly Culicoides obsoletus Meigen 1818), considered to be vectors of BTV and SBV (Mehlhorn et al, 2007;Carpenter et al, 2008;Hoffmann et al, 2009;De Regge et al, 2012;Elbers et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Orientation behaviour of Culicoides obsoletus (Diptera: Ceratopogonidae), a relevant virus vector in northern Europe, toward host-associated odorant cues

Zimmer

Verheggen

Haubruge

et al. 2015

Veterinary Parasitology

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a b s t r a c tSome Culicoides biting midge species (Diptera: Ceratopogonidae) are biological virus vectors worldwide and have recently been associated with outbreaks of important epizootic diseases such as bluetongue and Schmallenberg in northern Europe. These diseases, which affect domestic and wild ruminants, have caused considerable economic losses. Knowledge of host preferences of these biting midges -especially of the relevant vectors of arboviruses near farms, such as Culicoides obsoletus in northern Europe -is essential to understand pathogen transmission cycles and the epidemiology of associated diseases. This study aimed to determine host preferences of C. obsoletus using an in-field flight tunnel containing pairs of calf, sheep, chicken, and human hosts (and controls) and a laboratory two-choice bioassay containing volatile extracts of host skin (and controls). Behavioural responses of nulliparous C. obsoletus females in the in-field flight tunnel showed a preference for human (but also calf and sheep) hosts, probably due to their exhalation of greater quantities of carbon dioxide. The laboratory experiment revealed that volatile organic compounds released from the skin of chicken and sheep seemed to attract this species. Culicoides obsoletus, thus, seems to have a wide host range and to be particularly attracted by humans under field conditions. A better understanding of vector-host interaction could enable the development of control strategies against adult biting midges, by exploiting insect-repelling or -attractive semiochemicals. Volatile extracts of chicken and/or sheep skin could be used to identify volatile compounds attractive to C. obsoletus, which in turn could be used in baited traps.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Orientation behaviour of Culicoides obsoletus (Diptera: Ceratopogonidae), a relevant virus vector in northern Europe, toward host-associated odorant cues

Zimmer

Verheggen

Haubruge

et al. 2015

Veterinary Parasitology

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“…Nevertheless, the available data give a first impression on land cover variables explaining the distribution of the German Culicoides fauna. Moreover, the German land cover data ATKIS ® were successfully used to develop species distribution models for thirteen Culicoides species, including C. chiopterus, C. dewulfi, and C. scoticus as potential vectors of the BTV (Meiswinkel et al, 2007;Dijkstra et al, 2008) and Schmallenberg virus (Meiswinkel et al, 2007;Dijkstra et al, 2008;De Regge et al, 2012;Rasmussen et al, 2012). Furthermore, our study showed that multi-scale modelling is a promising approach to model the distribution of Culicoides species.…”

Section: Discussionmentioning

confidence: 99%

“…Several species of the genus Culicoides (Diptera: Ceratopogonidae) are considered to be potential vectors of the bluetongue virus (BTV) (Meiswinkel et al, 2007;Dijkstra et al, 2008) Culicoides species as capable vectors (Beer et al, 2013), as these are also here considered to be the main vectors (De Regge et al, 2012;Rasmussen et al, 2012). Although there is huge lack of knowledge about the causal connection between environmental variables and the distribution of biting midges, several studies modelled biting midge distribution and phenology using different sets of environmental data (e.g.…”

Section: Introductionmentioning

confidence: 99%

Comparison of single- and multi-scale models for the prediction of the Culicoides biting midge distribution in Germany

et al. 2016

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This study analysed Culicoides presence-absence data from 46 sampling sites in Germany, where monitoring was carried out from April 2007 until May 2008. Culicoides presence-absence data were analysed in relation to land cover data, in order to study whether the prevalence of biting midges is correlated to land cover data with respect to the trapping sites. We differentiated eight scales, i.e. buffer zones with radii of 0.5, 1, 2, 3, 4, 5, 7.5 and 10 km, around each site, and chose several land cover variables. For each species, we built eight single-scale models (i.e. predictor variables from one of the eight scales for each model) based on averaged, generalised linear models and two multiscale models (i.e. predictor variables from all of the eight scales) based on averaged, generalised linear models and generalised linear models with random forest variable selection. There were no significant differences between performance indicators of models built with land cover data from different buffer zones around the trapping sites. However, the overall performance of multi-scale models was higher than the alternatives. Furthermore, these models mostly achieved the best performance for the different species using the index area under the receiver operating characteristic curve. However, as also presented in this study, the relevance of the different variables could significantly differ between various scales, including the number of species affected and the positive or negative direction. This is an even more severe problem if multi-scale models are concerned, in which one model can have the same variable at different scales but with different directions, i.e. negative and positive direction of the same variable at different scales. However, multi-scale modelling is a promising approach to model the distribution of Culicoides species, accounting much more for the ecology of biting midges, which uses different resources (breeding sites, hosts, etc.) at different scales.

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“…The disease was rapidly spread to several European countries by midges of the genus Culicoides as C. dewulfi, C. chiopterus (de Regge et al 2012) and C. obsoletus. It has been demonstrated that the virus can replicate in the latter (Montgomery, Tack & Obonyo 2012).…”

Section: Introductionmentioning

confidence: 99%

Ausencia de Anticuerpos IgG al virus de Schmallenberg en sueros de rumiantes (bovino, caprinos y ovinos) colectados en Costa Rica entre 2012 y 2014.

Villegas-Salas¹,

Alvarado

Trejos-Araya

et al. 2017

Ciencias Veterinarias

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Absence of IgG antibodies against Schmallenberg virus in ruminant sera (bovine, goat and sheep) Abstract Schmallenberg virus affects ruminants, which causes significant economic losses. The virus is transmitted through vectors of the genus Culicoides; however, other studies do not rule out the possibility of sexual transmission due to its presence in semen. For this reason, the National Service of Animal Health of Costa Rica (SENASA) imposed restrictions on the import of semen from animals from the European Union in 2013. Consequently, SENASA conducted a study to determine the presence or absence of antibodies against this virus in bovine, ovine and caprine samples. As a result, no antibodies against this virus were detected in the 748 samples tested. It was concluded that Schmallenberg virus was not circulating in Costa Rican ruminants during the tested period.Keywords: Ruminants, SENASA, Schmallenberg virus, Costa Rica, serology. ResumenEl virus de Schmallenberg afecta a rumiantes produciendo pérdidas económicas importantes, el cual se transmite a través de artrópodos del género Culicoides, sin embargo, no se descarta la posibilidad de transmisión sexual debido a la presencia del virus en semen, razón por la cual, el Servicio Nacional de Salud Animal de Costa Rica (SENASA), estableció restricciones a la importación de semen de rumiantes procedentes de la Unión Europea en el 2013. En consecuencia, el SENASA realizó un estudio para determinar la presencia o ausencia de anticuerpos contra este virus en muestras de bovinos, ovinos y caprinos. Como resultado de este estudio no se encontró la presencia anticuerpos contra el virus de Schmallenberg en ninguna de las 748 muestras evaluadas, por lo que se concluye que este virus no está circulando en los rumiantes de Costa Rica.Palabras claves: Rumiantes, SENASA, virus Schmallenberg, Costa Rica, serología.Rev. Ciencias Veterinarias, Vol. 35, N° 2,[103][104][105][106][107][108][109][110][111][112] IntroductionReports of emerging and re-remerging viral diseases have increased over the last decade. Some of these etiological agents produce diseases that concern health authorities and professionals worldwide because of the unpredictable effects and impact of these agents (Ruiz-Fons 2012).Diseases transmitted by arthropods that affect human and animal populations are causing serious local and international health problems, especially in underdeveloped countries. Schmallenberg virus (SBV) is a clear example of these emerging diseases (Alarcón-Elbal & Lucientes 2012). This epizootic disease began in the summer of 2011 in northwestern Germany and the eastern region of the Netherlands. In October 2011, the virus was identified by researchers of the Friedrich Loeffler Institut (FLI), Federal Research Institute for Animal Health in Germany (Bilk et al. 2012). Schmallenberg disease was characterized by clinical signs such as fever, diarrhea, and decreased milk production (Gariglinany et al. 2012). The acute disease in pregnant females was followed by an epidemic of stillbirths an...

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Detection of Schmallenberg virus in differentCulicoidesspp. by real-time RT-PCR

Cited by 180 publications

References 16 publications

Orientation behaviour of Culicoides obsoletus (Diptera: Ceratopogonidae), a relevant virus vector in northern Europe, toward host-associated odorant cues

Orientation behaviour of Culicoides obsoletus (Diptera: Ceratopogonidae), a relevant virus vector in northern Europe, toward host-associated odorant cues

Comparison of single- and multi-scale models for the prediction of the Culicoides biting midge distribution in Germany

Ausencia de Anticuerpos IgG al virus de Schmallenberg en sueros de rumiantes (bovino, caprinos y ovinos) colectados en Costa Rica entre 2012 y 2014.

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