Detection of sensitizing tissue culture components in viral vaccines

Wilson, S.; Weber, J. C. W.; Aprile, M; Macmorine, H. G.

doi:10.1016/0021-8707(68)90094-4

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…However, overproduction of the proinflammatory cytokines can have mild to very severe adverse side affects. (Bonin et al, 1973;Wilson et al, 1968;Erdos et al, 1975). As with all of the hypersensitivity reactions, the animal will not react on first exposure to an antigen (unless it has received passive antibody responsible for the reaction).…”

Section: E Adverse Vaccine Reactions Due To Excessive Induction Of Cmentioning

confidence: 99%

Mechanistic Bases for Adverse Vaccine Reactions and Vaccine Failures

Roth

1999

Advances in Veterinary Medicine

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Section: E Adverse Vaccine Reactions Due To Excessive Induction Of Cmentioning

confidence: 99%

Mechanistic Bases for Adverse Vaccine Reactions and Vaccine Failures

Roth

1999

Advances in Veterinary Medicine

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“…Die vorliegenden Befunde gewinnen hinsichtlich der Pathogenese versehiedener Erkrankungen an Bedeutung, beispielsweise allergiseher Reaktionen gegen Wirtszellbestandteile naeh Sehutzimpfnngen (14) nnd Autoimmunkrankheiten durch Produktion yon Autoantik6rpern nach Virusinfektionen (15).…”

Section: Diskussionunclassified

Untersuchungen zum Mechanismus der immunologischen Adjuvanswirkung des Vacciniavirus

Bandlow

Fischer

Thomssen

1972

Archiv f Virusforschung

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Zusammenfassun 9Vacciniavirus wirkt immunologisch adjuvierend bei der Produktion heterologer, gegen Wirtszellantigene gerichteter zytotoxischer AntikSrper. Dicser Adjuvanseffekt konnte bei aktiver Immunisierung yon Meerschweinchen mit verschiedenen Wirtszellen, i. e. BHK-Zellen, Affennierenzellen, Kaninchennierenzellen, humanen embryonalen Fibroblasten, prim/~ren mensehliehen Zetlen aus Hirntumoren, embryonalen M/msefibroblasten und M/~usetumorzellen demonstriert werden. Naeh schonender Inaktivierung dcr Infektiosit/~t des Virus mit Formalin bleibt der adjuvierende Effekt roll erhalten. Die gesteigerte Immunogenit/it der Wirtszelle ist schon vor der Produktion reifer infekti5ser Viruspartikeln naehweisbar, Sic ist zeitlich mit dem Auftreten spezifischer Virusantigene in der Zellmembran korreliert. Dureh Vorbehandlung des virushaltigen Antigenmaterials mit virusspezifischen Antik6rpern in vitro kann die adjuvierende Wirkung unterdriickt werden. Summary Studies on the 1Vfechanism of the Immunological Adjuvant Effect of VacciniavirusVaceiniavirus acts as an immunological adjuvant in the production of heterologous cytotoxic antibodies against host cell antigens. This adjuvant effect was demonstrated by active immunisation of guinea pigs with different host cells, such as BHK-cells, monkey kidney cells, rabbit kidney cells, human embryonic fibroblasts, cells of human brain turnouts, fibroblasts of embryonic mice and tumourcells of mice. After careful treatment of the virus-cell antigen with formalin the adjuvant effect is still present, although the infectivity of the virus was abolished. Increased immunogenicity of host cells could already be observed before any mature vaecinia particles were produced. It coincides with the appearence of virusspecific antigens on the surface of the cell membrane. The adjuvant effect could be suppressed by treating in vitro the material that containes the virus and the host cell antigens, wi~h specific antibodies against the virus.

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