Detection of Serous Tubal Intraepithelial Carcinoma along with High Grade Serous Carcinoma of Both Ovaries

Abstract

High-grade serous carcinoma (HGSC) of ovary is the commonest of all ovarian malignant tumours and is associated with high mortality rate. Serous tubal intraepithelial carcinoma (STIC) is believed to be the precursor lesion. In literature, only 40-50% of HGSC shows concurrent STIC, even after thorough sampling. We, herein, present a case of a 40-year female, who underwent staging laparotomy for bilateral ovarian carcinoma. She was diagnosed as HGSC of both ovaries. Left ovary capsule was focally ruptured. Peritoneal washings showed metastatic carcinoma. Provisional FIGO stage was IC. During sampling, concurrent finding of STIC was documented in right fallopian tube. No invasive carcinoma was present in both entirely submitted fallopian tubes.

Copy number variations and protein expression of Cyclin E1 and Epithelial cell transforming sequence 2 genes predict the chemotherapeutic response in patients with serous ovarian carcinoma

“…Nearly all national and international studies on SOC give a high percentage of HGSOC as compared to LGSOC. 6,[17][18][19] The present study reported 20% cases in FIGO Stage-I, 12% in Stage-II, 40% in Stage-III while 28% in Stage-IV. A 35 years cohort study from Scotland reported large number of cases (40%-50%) in Stage-III similar to the present study.…”