Detection of serum anti-<i>Helicobacter pylori</i>immunoglobulin G in patients with different digestive malignant tumors

Wang, Ke-xia; Wang, Xuefeng; Peng, Jiang-Long; Cui, Yubao; Wang, Jian; Chao-pin, LI

doi:10.3748/wjg.v9.i11.2501

Cited by 17 publications

(20 citation statements)

References 31 publications

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“…It has also been reported that the remote and local consequences of H. pylori infection might also have a synergistic effect on the emergence or development of these neoplasms under certain conditions [ 4 , 8 ]. A study of 374 patients with GI cancers evaluated serologic H. pylori positivity according to localization, serologic H. pylori positivity was found to be unrelated to CC localization [ 24 ]. In an investigation for H. pylori specific 16S rDNA with PCR in CC biopsies, Grahn et al revealed H. pylori DNA in 27% of cancer tissue specimens.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical testing for Helicobacter Pyloriexistence in neoplasms of the colon

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical testing for Helicobacter Pyloriexistence in neoplasms of the colon

et al. 2008

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“…The literature search identified 948 potentially relevant articles. Based on our inclusion criteria, a total of 28 studies [13][14][15][17][18][19][20][21][22][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] were included in qualitative synthesis (Fig. 1).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Detailed characteristics of the aggregated data for the 28 studies are summarized in Table 1. In total, nine studies 14,17,18,33,36,38,40,41,46 concerned EAC, 15 concerned ESCC, 13,15,20,22,[29][30][31][32]34,35,39,[42][43][44][45] and four 19,21,37,47 concerned both. There were 13 studies in Asian populations and 15 studies in non-Asian subjects.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Association ofHelicobacter pyloriinfection with esophageal adenocarcinoma and squamous cell carcinoma: a meta-analysis

et al. 2014

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To evaluate the relationship of Helicobacter pylori and cytotoxin-associated gene A (CagA) positive strains with esophageal neoplasm, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), the authors conducted a meta-analysis using a predefined protocol. PubMed, Web of Science, China biology medical literature database, Wanfang, and China National Knowledge Infrastructure were searched for relevant articles from the first available year to April 8, 2013. The fixed or random effect pooled measure was selected based on heterogeneity among studies, which was evaluated using Q test and the I(2) of Higgins and Thompson. Metaregression was used to explore the sources of between-study heterogeneity. Publication bias was analyzed by Begg's funnel plot and Egger's regression test. The association was assessed by odds ratio (OR) with 95% confidence interval (CI). A total of 28 eligible studies were included in the meta-analysis. There was a significant inverse association between H. pylori infection (pooled OR, 0.57; 95% CI, 0.44-0.73) and EAC; CagA-positive H. pylori strains were less likely to be associated with EAC compared with CagA-negative strains (pooled OR, 0.64; 95% CI, 0.52-0.79). However, there was no statistically significant association between H. pylori/CagA-positive H. pylori strains infection and ESCC, and the pooled ORs were 1.16 (95% CI, 0.83-1.60) and 0.97 (95% CI, 0.79-1.19). But significant associations between CagA-positive H. pylori strains infection and ESCC risk were found in the stratified analysis of the study location (Asian and non-Asian), and the summary ORs were 0.74 (95% CI, 0.57-0.97) and 1.41 (95% CI, 1.02-1.94). H. pylori infection and CagA-positive strains are associated with decreased risk of EAC in the overall population. No significant association was found between H. pylori infection/CagA-positive strains and ESCC. But CagA-positive strains might have a positive association with ESCC in non-Asian population and an inverse association in Asian population.

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“…Helicobacter pylori (H pylori) infection is associated with an increased risk of both peptic ulcer and gastric cancer [1] Chronic gastritis induced by H pylori significantly increases the risk for non-cardiac gastric cancer [2,3] , and host responses that may affect the threshold for carcinogenesis include alteration of epithelial cell proliferation and apoptosis. Although the linkage between H pylori infection and gastric cancer is convincing, the molecular mechanism or mechanisms responsible are unclear, and both bacterial and host factors are implicated.…”

Section: Introductionmentioning

confidence: 99%

Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor κ B expression and enhanced antiapoptosis-related proteins inHelicobacter pylori-infected non-cardiac gastric adenocarcinoma

Chang¹,

Chen²,

Lin³

et al. 2004

WJG

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AIM:Several epidemiological studies have demonstrated a close association between Helicobacter pylori (H Pylori) infection and non-cardiac carcinoma of the stomach. H pylori infection induces active inflammation with neutrophilic infiltrations as well as production of oxygen free radicals that can cause DNA damage. The DNA damage induced by oxygen free radicals could have very harmful consequences, leading to gene modifications that are potentially mutagenic and/or carcinogenic. The aims of the present study were to assess the effect of H pylori infection on the expression of inducible nitric oxidative synthase (iNOS) and the production of 8-hydroxy-deoxyguanosine (8-OHdG), a sensitive marker of oxidative DNA injury in human gastric mucosa with and without tumor lesions, and to assess the possible factors affecting cell death signaling due to oxidative DNA damage. METHODS:In this study, 40 gastric carcinoma specimens and adjacent specimens were obtained from surgical resection. We determined the level of 8-OHdG formation by HPLC-ECD, and the expression of iNOS and mechanism of cell death signaling [including nuclear factor-κB(NFκB), MEKK-1, Caspase 3, B Cell lymphomal leukemia-2 (Bcl-2), inhibitor of apoptosis protein (IAP ) and myeloid cell leukemia-1 (Mcl-1)] by Western-blot assay. RESULTS:The concentrations of 8-OHdG, iNOS, NFκB, Mcl-1 and IAP were significantly higher in cancer tissues than in adjacent non-cancer tissues. In addition, significantly higher concentrations of 8-OHdG, iNOS, NFκB, Mcl-1 and IAP were detected in patients infected with H pylori compared with patients who were not infected with H pylori. Furthermore, 8-OHdG, iNOS, NFκB, Mcl-1 and IAP concentrations were significantly higher in stage 3 and 4 patients than in stage 1 and 2 patients. CONCLUSION:Chronic H pylori infection induces iNOS expression and subsequent DNA damage as well as enhances anti-apoptosis signal transduction. This sequence of events supports the hypothesis that oxygen-free radical-mediated damage due to H pylori plays a pivotal role in the development of gastric carcinoma in patients with chronic gastritis.Chang CS, Chen WN, Lin HH, Wu CC, Wang CJ. Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor κB expression and enhanced antiapoptosisrelated proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma. World J Gastroenterol 2004; 10 (15): 2232-2240

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Detection of serum anti-Helicobacter pyloriimmunoglobulin G in patients with different digestive malignant tumors

Abstract: H pylori infection is associated with occurrence and development of gastric and duodenal carcinomas. Furthermore, it is also associated with histological type and locations of gastric and duodenal carcinomas.

Cited by 17 publications

References 31 publications

Immunohistochemical testing for Helicobacter Pyloriexistence in neoplasms of the colon

Immunohistochemical testing for Helicobacter Pyloriexistence in neoplasms of the colon

Association ofHelicobacter pyloriinfection with esophageal adenocarcinoma and squamous cell carcinoma: a meta-analysis

Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor κ B expression and enhanced antiapoptosis-related proteins inHelicobacter pylori-infected non-cardiac gastric adenocarcinoma

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